Abstract: A method of manufacturing a heating block includes a first step of providing a ceramic material to a mold, a second step of sintering the ceramic material and forming a plate, and a third step of machining the plate. A shaft is connected to the plate in a fourth step, and rods are bonded to the plate in a fifth step of the method. Heating blocks and semiconductor processing systems having heating blocks are also described.

Abstract: The present invention provides medicaments for use in treating and methods of treating T-cell acute lymphoblastic leukemia, acute lymphoblastic leukemia, chronic lymphoblastic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, erythroleukemia, triple negative breast cancer, breast cancer, ovarian cancer, melanoma, Sung cancer, non small-cell lung cancer, pancreatic cancer, glioblastoma, colorectal cancer, head and neck cancer, cervical cancer, prostate cancer, liver cancer, oral squamous cell carcinoma, skin cancer, medul!ob!astoma, hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, desmoid tumor, soft tissue sarcoma, or adenoid cystic carcinoma in a patient comprising combination therapy with 4,4,4-tri-fluoro-N-[(1S)-2˜[[(7S)-5-(2-hydroxyemyl)-6-oxo-7H-pyrido[23-d][3]benzazepin-7-yl]amino]-1-methyl-2-oxo-ethyljbutanamide, or a pharmaceutically acceptable salt or hydrate thereof, and a PD-1 or a PD-L1 inhibitor selected from pembrolizumab, nivolumab, atezolizumab, dur

Abstract: Disclosed are a system and method for processing HL7 messages. A method includes receiving, an HL7 message; storing the HL7 message in a memory; creating a data structure representation of the stored HL7 message in the memory that stores a start index and an end index of the stored HL7 message, wherein the start index indicates a beginning of the stored HL7 message and the end index indicates an end of the stored HL7 message; hierarchically creating, from the data structure representation of the stored HL7 message, one or more data structure representations in the memory that store at least one start index and at least one end index corresponding to one or more fragments in the stored HL7 message; and, modifying the stored HL7 message according to the at least one start index and a corresponding end index of the fragments in the HL7 message.

Abstract: The technology disclosed relates to determining pathogenicity of nucleotide variants. In particular, the technology disclosed relates to specifying a particular amino acid at a particular position in a protein as a gap amino acid, and specifying remaining amino acids at remaining positions in the protein as non-gap amino acids. The technology disclosed further relates to generating a gaped spatial representation of the protein that includes spatial configurations of the non-gap amino acids, and excludes a spatial configuration of the gap amino acid, and determining a pathogenicity of a nucleotide variant based at least in part on the gaped spatial representation, and a representation of an alternate amino acid coated by the nucleotide variant at the particular position.

Abstract: The technology disclosed relates to constructing a convolutional neural network-based classifier for variant classification. In particular, it relates to training a convolutional neural network-based classifier on training data using a backpropagation-based gradient update technique that progressively match outputs of the convolutional neural network-based classifier with corresponding ground truth labels. The convolutional neural network-based classifier comprises groups of residual blocks, each group of residual blocks is parameterized by a number of convolution filters in the residual blocks, a convolution window size of the residual blocks, and an atrous convolution rate of the residual blocks, the size of convolution window varies between groups of residual blocks, the atrous convolution rate varies between groups of residual blocks. The training data includes benign training examples and pathogenic training examples of translated sequence pairs generated from benign variants and pathogenic variants.

Abstract: The invention discloses a method for preparing a stainless steel seamless tube with ultra-high cleanliness for an integrated circuit and an IC industry preparation device, and a stainless steel seamless tube with ultra-high cleanliness. The stainless steel seamless tube which comprises, by mass, C?0.010%, P?0.020%, S?0.010%, Mn?0.10%, Si?0.30%, Se?0.010%, Al?0.010%, Cu?0.20%, Cr16.50-17.00%, Ni14.50-15.00%, Mo2.20-2.50%, N?0.010%, Ni?0.010%, Ti?0.010% and the balance Fe and impurities is prepared through a: a stainless steel refining process; b: a vacuum induction melting and vacuum consumable remelting process; c: a stainless steel forging process; d: a hot piercing process; e: a cold working process; f: an inner bore electrolytic polishing, pickling and passivation process; and g: a cleaning process.

Abstract: Disclosed are a resource scheduling method, an electronic device and a storage medium. The resource scheduling method may include: acquiring an intelligent application processing request acquiring current resource usage information; matching an intelligent application instance according to the intelligent application processing request and creating a task according to the resource usage information and the intelligent application instance, to process the intelligent application processing request.

Abstract: A resource scheduling method, a resource scheduling system, a device, and a computer-readable storage medium are disclosed. The resource scheduling method may include: obtaining a scheduling object from a scheduling queue (S100); and when the scheduling object is a customized resource, splitting the customized resource according to the current resource state to obtain a scheduling unit list (S200), the scheduling unit list including first scheduling units configured to form the customized resource; and sequentially scheduling the first scheduling units in the scheduling unit list (S300).

Abstract: An integrated circuit (IC) device includes a master latch circuit having a first clock input and a data output, a slave latch circuit having a second clock input and a data input electrically coupled to the data output of the master latch circuit, and a clock circuit. The clock circuit is electrically coupled to the first clock input by a first electrical connection configured to have a first time delay between the clock circuit and the first clock input. The clock circuit is electrically coupled to the second clock input by a second electrical connection configured to have a second time delay between the clock circuit and the second clock input. The first time delay is longer than the second time delay.

Abstract: Described herein are technologies for classifying a protein structure (such as technologies for classifying the pathogenicity of a protein structure related to a nucleotide variant). Such a classification is based on two-dimensional images taken from a three-dimensional image of the protein structure. With respect to some implementations, described herein are multi-view convolutional neural networks (CNNs) for classifying a protein structure based on inputs of two-dimensional images taken from a three-dimensional image of the protein structure. In some implementations, a computer-implemented method of determining pathogenicity of variants includes accessing a structural rendition of amino acids, capturing images of those parts of the structural rendition that contain a target amino acid from the amino acids, and, based on the images, determining pathogenicity of a nucleotide variant that mutates the target amino acid into an alternate amino acid.

Abstract: A heater assembly having a laminate heater plate and a shaft. The laminate heater plate is formed from a plurality of layers, wherein one or more layers may comprise one or more of a heating element, an RF electrode, a cooling channel, and an RTD sensor.

Abstract: A substrate handling chamber body is formed from a castable aluminum alloy including a manganese (Mn) constituent and an iron (Fe) constituent. The castable aluminum alloy has a manganese (Mn) constituent-to-iron (Fe) constituent ratio that between about 1.125 and about 1.525 to limit microporosity and shrinkage porosity within the castable aluminum alloy forming the substrate handling chamber body. Semiconductor processing systems and methods of making substrate handling chamber bodies for semiconductor processing systems are also described.

Abstract: A circuit board includes a first layer, a second layer, a third layer, a plurality of plating through holes, at least one first intermediate layer and at least one second intermediate layer. The first layer and the second layer are used as reference voltage planes. A plurality of transmission wires are disposed on the third layer. The transmission wires are coupled to a wireless signal transceiver and a plurality of antenna arrays; wherein the third layer is disposed between the first layer and the second layer. The plating through holes are disposed at sides of the third layer, wherein the plurality of plating through holes are configured to connect the first reference voltage plane with the second reference voltage plane. The first intermediate layer is disposed between the first layer and the third layer, and the second intermediate layer is disposed between the second layer and the third layer.

Abstract: An on-line oil injection lubrication system of a small-caliber cold pipe blank unit comprises at least one intelligent oil supply assembly. The intelligent oil supply assembly comprises an upper industrial personal computer, a vector frequency converter and a hydraulic pump. The upper industrial personal computer adjusts the quantity of oil supplied by the hydraulic pump to the pipe blank inner hole oil injection assembly and/or the pipe blank outer surface oil injection assembly through the vector frequency converter. The on-line oil injection lubrication system can remarkably improve the quality of inner and outer surfaces of small-caliber stainless steel pipes and effectively solves various surface quality problems such as rolling burrs, rolling folds and micro-cracks caused by oil loss of the inner and outer surfaces of the small-caliber stainless steel pipes during the large-deformation rolling process.

Abstract: A substrate support includes a heater body, a heater element, and a heater terminal. The heater body is formed from a ceramic material and has upper and lower surfaces separated by a thickness. The heater element is arranged between the upper and lower surfaces and is embedded within the ceramic material forming the heater body. The heater terminal is arranged between the upper and lower surfaces, is electrically connected to the heater element, and has an electrode surface and a rounded surface. The electrode surface opposes the lower surface to flow an electric current to the heater element. The rounded surface opposes the upper surface and is embedded within the ceramic material to limit stress within the ceramic material during heating of a substrate seated on the upper surface of the heater body. Semiconductor processing systems and methods of making substrate supports for semiconductor processing systems are also described.

Abstract: A first reference genome is segmented into a plurality of bins and high-quality sequenced reads are mapped on a bin-by-bin basis to the plurality of bins in the first reference genome, and a second reference genome is segmented into a plurality of bins and high-quality sequenced reads are mapped on a bin-by-bin basis to the plurality of bins in the second reference genome. A best-mapped bin is identified in the second reference genome based on the greatest degree of match between the best-mapped bin in the second reference genome and a corresponding bin in the first reference genome.

Abstract: The technology disclosed relates to determining feasibility of using a reference genome of a non-target species for variant calling a sample of a target species. In particular, the technology disclosed relates to mapping sequenced reads of a sample of a target species to a reference genome of a non-target species to detect a first set of variants in the sequenced reads of the sample of the target species, and mapping the sequenced reads of the sample of the target species to a reference genome of a pseudo-target species to detect a second set of variants in the sequenced reads of the sample of the target species.

Abstract: The technology disclosed relates to identifying differential selective constraint on a gene-by-gene basis between a target species and one or more non-target species. The disclosed systems and methods can use a population genetics model wherein an average selection coefficient per gene per species is estimated and further applied to estimate selective constraint. The disclosed systems and methods can use a generalized linear mixed model wherein depletion of missense variants per gene per species is estimated and further applied to estimate selective constraint. In some cases, the disclosed systems and methods can use various combinations of the components from the population genetics model or the generalized linear mixed model to identify the intersection of genes classified as having differential selective constraint by numerous approaches for validation purposes.

Abstract: The technology disclosed relates to variant calling of sequenced reads of a sample of a target species against a reference genome of a pseudo-target species. Low-quality variants are identified as false positive variants that are present in the second set of variants but absent from the first set of variants.

Abstract: The present disclosure provides an organic light emitting diode (OLED) display panel and a display panel which include a display region, a binding region, and a bending region. A metal trace inside the bending regions generates a tensile stress region and a compressive stress region. A plurality of through holes are disposed on the metal trace. A distribution density of the through holes corresponding to the tensile stress region is different from distribution density of the through holes corresponding to the compressive stress region. It may relieve the stress, reduce the problems such as failure and bad products, reduce the bending angle to be smaller, and achieve narrower borders.