Abstract: A method, performed by an authoring system, of authoring content for a high-precision fire-dynamics-simulation (FDS) is provided. The authoring system selects a target object from an object DB storing a three-dimensional model of each object made to correspond to surface information indicating at least one material constituting a surface of the three-dimensional model and material information indicating fire attribute information of each material; arranges the selected target object in a three-dimensional space to author content for the FDS; converts the content for the FDS into an FDS input file used as an input for a simulator for the FDS; and outputs the FDS input file to the simulator.

Abstract: Provided is a hemostatic dressing. The hemostatic dressing includes: a porous matrix layer including a biocompatible polymer; a hemostatic layer loaded on the porous matrix layer and including a polymer in which polyhydric phenol-containing moieties are introduced; and a binding layer interposed between the porous matrix layer and the hemostatic layer to prevent the porous matrix layer from being separated from the hemostatic layer.

Abstract: A fire-fighting virtual reality simulator allows the trainee to move in a virtual space in various complex virtual fire disaster situations and perform a suppression of a virtual fire and a confrontation training. An experience interactive simulator for providing a trainee with a floor movement that may occur in a fire disaster situation so that the trainee wearing HMD in a virtual fire-fighting training has the same sense of feeling as that in an actual fire-fighting training is provided. For the realistic content experience, a physical floor movement, such as tilting, falling, and shaking of the floor is reproduced using a base motion, thereby providing a floor movement that enables a sense of feeling similar to a fire disaster situation.

Abstract: Proposed are a stabilizer for an adeno-associated virus (AAV) and a method for stabilizing an adeno-associated virus using the same. More particularly, the present disclosure relates to a stabilizer for an adeno-associated virus including a surfactant or albumin, an adeno-associated virus liquid formulation including adeno-associated virus the stabilizer, and a production method for an adeno-associated virus with improved stability. The technology, according to the present disclosure, inhibits excessive aggregation between viruses when producing a gene delivery virus and therapeutic nanoparticles using an adeno-associated virus and forming an additional polyphenol binder for this purpose, thereby maintaining the particle size to an effective size for drug delivery and improving the stability in the liquid phase. Therefore, the technology is expected to be very useful in the field of drug delivery technology for gene therapy.

Abstract: A fire-fighting virtual reality simulator allows the trainee to move in a virtual space in various complex virtual fire disaster situations and perform a suppression of a virtual fire and a confrontation training. An experience interactive simulator for providing a trainee with a floor movement that may occur in a fire disaster situation so that the trainee wearing HMD in a virtual fire-fighting training has the same sense of feeling as that in an actual fire-fighting training is provided. For the realistic content experience, a physical floor movement, such as tilting, falling, and shaking of the floor is reproduced using a base motion, thereby providing a floor movement that enables a sense of feeling similar to a fire disaster situation.

Abstract: Disclosed herein are a motion-based virtual-reality simulator device and a method for controlling the same. The motion-based virtual-reality simulator device includes a virtual-reality interface for outputting virtual reality content in a form of multi-sense data that is perceptible by a user, a virtual-reality movement implementation unit including a track component for performing continuous track motion in a state in which a user gets on the track component, the track component being configured such that a slope of the track component is controlled while a surface of the track component is deformed into an even surface or an uneven surface, and an interworking control unit for outputting a control signal to the virtual-reality movement implementation unit so that a slope and a surface of the track component are deformed in accordance with the virtual reality content that is output through the virtual-reality interface.

Abstract: A manufacturing device for a microneedle includes an upper plate stage, a lower plate stage disposed in horizontally parallel with the upper plate stage, a rotating device configured to rotate and move the upper plate stage over the lower plate stage, and a first cylindrical type actuator configured to vertically move the lower plate stage in a state in which the upper plate stage has been rotated and moved over the lower plate stage by the rotating device. The first cylindrical type actuator may upwardly and downwardly move so as to be able to stretch a viscous composition in a vertical direction in a state in which a contacting to the viscous composition is performed, wherein the viscous composition is applied on both of a patch sheet seated on the upper plate stage and a patch sheet seated on the lower plate stage, or is applied on one of them.

Abstract: The present disclosure relates to a method for manufacturing a microneedle enabling product quality and efficiency in production to be improved by reducing the time needed for spotting a viscous material. The method for manufacturing a microneedle, according to the present disclosure, comprises the steps of spotting a viscous material on a plurality of spots on a film by supplying the viscous material to the upper surface of the film by means of a plurality of through-holes provided on an injection plate, elongating the viscous material spotted on the film; and coagulating the elongated viscous material.

Abstract: The present invention relates to a pharmaceutical composition containing leuprolide acetate and having both immediate and sustained release properties and, more specifically, to a pharmaceutical composition in which, on the basis of the total weight of active ingredients, leuprolide as an immediate release preparation is contained in 0.001 wt % to 25 wt %; and leuprolide contained in microspheres of a sustained release preparation is contained in 75 wt % to 99.999 wt %. The pharmaceutical composition of the present invention is characterized by satisfying both a drug immediate release property so as to realize the prompt exposure to a sufficient amount of drug at the early stage for expression of medicinal effects and a drug sustained release property for four weeks or longer, and the pharmaceutical composition is effective in the prevention and treatment of sex hormone-dependent positive or malignant diseases.

Abstract: There are provided a micro-needle patch for diagnosing and treating an allergy disease which can easily and effectively inject an allergen into a dermal layer of an entity, a method for producing the micro-needle patch, and a method for diagnosing an allergy disease using the micro-needle patch. The micro-needle patch includes a plurality of micro-needles constructed to inject an allergen into an entity; and a pad for supporting the plurality of micro-needles. The micro-needle patch in accordance with the present disclosure may inject the allergen easily and effectively into the dermis of the entity, thereby to allow diagnosing or treating the allergy disease easily and efficiently without causing great pain to the patient. Further, controlling the type and content of the allergen contained in the micro-needle patch may allow diagnosing or treating allergy diseases accurately.

Abstract: A manufacturing method of a microstructure includes providing a patch manufacturing sheet formed in a state in which a bottom layer is exposed on an upper part thereof; providing the patch manufacturing sheet on a first process substrate and a second process substrate; spotting a viscous composition at a plurality of positions spaced apart from each other on the bottom layer of the patch manufacturing sheet provided on only the first process substrate, or provided on both of the first process substrate and the second process substrate; contacting the patch manufacturing sheet provided on the second process substrate or the viscous composition to the viscous composition spotted on the patch manufacturing sheet provided on the first process substrate; moving relatively the second process substrate with respect to the first process substrate to stretch the viscous composition and to coagulate the stretched viscous composition; and cutting the coagulated viscous composition.

Abstract: The present disclosure relates to a method for manufacturing a microneedle enabling product quality and efficiency in production to be improved by reducing the time needed for spotting a viscous material. The method for manufacturing a microneedle, according to the present disclosure, comprises the steps of spotting a viscous material on a plurality of spots on a film by supplying the viscous material to the upper surface of the film by means of a plurality of through-holes provided on an injection plate, elongating the viscous material spotted on the film; and coagulating the elongated viscous material.

Abstract: The present invention provides a pharmaceutical composition with improved stability, comprising a fusion protein comprising Factor VII (FVII) and transferrin, as an active ingredient, wherein the transferrin is linked to the C-terminus of the FVII; and trehalose or glycine as a bulking agent. The composition can store FVII and a variant thereof stably at room temperature for a long period of time. Thus it can be used as a useful therapeutic agent for patients suffering from hemophilia or congenital FVII deficiency.

Abstract: The present invention relates to a pharmaceutical composition containing leuprolide acetate and having both immediate and sustained release properties and, more specifically, to a pharmaceutical composition in which, on the basis of the total weight of active ingredients, leuprolide as an immediate release preparation is contained in 0.001 wt % to 25 wt %; and leuprolide contained in microspheres of a sustained release preparation is contained in 75 wt % to 99.999 wt %. The pharmaceutical composition of the present invention is characterized by satisfying both a drug immediate release property so as to realize the prompt exposure to a sufficient amount of drug at the early stage for expression of medicinal effects and a drug sustained release property for four weeks or longer, and the pharmaceutical composition is effective in the prevention and treatment of sex hormone-dependent positive or malignant diseases.

Abstract: An interactive content control apparatus and method includes a depth information acquisition unit for acquiring an image that includes depth information by capturing a static background object and a dynamic foreground object, and for calculating depth maps based on respective depth values of the static background object and the dynamic foreground object from the image, a display unit for projecting image content including a background image and an object image on a surface of the static background object captured by the depth information acquisition unit, and an image mapping unit for recognizing the dynamic foreground object depending on the depth maps based on the depth values calculated by the depth information acquisition unit, and controlling the display unit so that an object image projected on the surface of the static background object is transferred to and projected on a surface of the dynamic foreground object.

Abstract: A manufacturing device for a microneedle includes an upper plate stage, a lower plate stage disposed in horizontally parallel with the upper plate stage, a rotating device configured to rotate and move the upper plate stage over the lower plate stage, and a first cylindrical type actuator configured to vertically move the lower plate stage in a state in which the upper plate stage has been rotated and moved over the lower plate stage by the rotating device. The first cylindrical type actuator may upwardly and downwardly move so as to be able to stretch a viscous composition in a vertical direction in a state in which a contacting to the viscous composition is performed, wherein the viscous composition is applied on both of a patch sheet seated on the upper plate stage and a patch sheet seated on the lower plate stage, or is applied on one of them.

Abstract: A manufacturing method of a microstructure includes providing a patch manufacturing sheet formed in a state in which a bottom layer is exposed on an upper part thereof; providing the patch manufacturing sheet on a first process substrate and a second process substrate; spotting a viscous composition at a plurality of positions spaced apart from each other on the bottom layer of the patch manufacturing sheet provided on only the first process substrate, or provided on both of the first process substrate and the second process substrate; contacting the patch manufacturing sheet provided on the second process substrate or the viscous composition to the viscous composition spotted on the patch manufacturing sheet provided on the first process substrate; moving relatively the second process substrate with respect to the first process substrate to stretch the viscous composition and to coagulate the stretched viscous composition; and cutting the coagulated viscous composition.

Abstract: An apparatus for displaying image content based on pop-up book includes: a database for storing multiple pieces of reference depth-based mesh information, acquired for each page of pop-up book where stereoscopic shapes stand when the pop-up book is opened, and image content corresponding to each page; a depth information acquisition unit for acquiring an image including depth information by capturing the current page where the stereoscopic shapes protrude as a result of opening the pop-up book at arbitrary point, and generating depth-based mesh information about the current page; and a display unit for recognizing the current page by matching the multiple reference depth-based mesh information with the depth-based mesh information about the current page, generated by the depth information acquisition unit, extracting image content corresponding to the recognized current page from the database, and projecting it onto the current page.

Abstract: The present invention relates to a method for preparing polymeric microspheres to improve the drug encapsulating efficiency and, more specifically, to a method for preparing polymeric microspheres, the method comprising the steps of: preparing an internal water phase (w1) and an oil phase (0); mixing the internal water phase and the oil phase to prepare a W1/0 emulsion, followed by cooling; mixing the W1/0 emulsion with an external water phase (W2) to prepare a W1/0/W2 emulsion; and drying the prepared W1/0/W2 emulsion, followed by collection. The method of the present invention can increase the drug encapsulating efficiency and manufacture polymeric microspheres having high drug contents through a procedure of maintaining the step of solidifying the oil phase at a particular temperature for a particular period of time, and thus the method of the present invention is effective in the preparation of sustained release-type drugs.

Abstract: The present invention provides a pharmaceutical composition with improved stability, comprising a fusion protein comprising factor VII(FVII) and transferrin, as an active ingredient, wherein the transferrin is linked to the C-terminus of the FVII; and trehalose or glycine as a bulking agent. The composition can store FVII and a variant thereof stably at room temperature for a long period of time. Thus it can be used as a useful therapeutic agent for patients suffering from hemophilia or congenital FVII deficiency.