Patents by Inventor Hong-Ming Shieh
Hong-Ming Shieh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9409893Abstract: The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.Type: GrantFiled: November 8, 2013Date of Patent: August 9, 2016Assignee: Jacobus Pharmaceutical Company, Inc.Inventors: Gavin David Heffernan, David Penman Jacobus, Kurt William Saionz, Guy Alan Schiehser, Hong-Ming Shieh, Wenyi Zhao
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Patent number: 9296696Abstract: The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.Type: GrantFiled: November 25, 2014Date of Patent: March 29, 2016Assignee: Jacobus Pharmaceuticals Company, Inc.Inventors: Gavin David Heffernan, David Penman Jacobus, Guy Alan Schiehser, Hong-Ming Shieh, Wenyi Zhao
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Publication number: 20150080324Abstract: The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.Type: ApplicationFiled: November 25, 2014Publication date: March 19, 2015Inventors: Gavin David Heffernan, David Penman Jacobus, Guy Alan Schiehser, Hong-Ming Shieh, Wenyi Zhao
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Patent number: 8962657Abstract: The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.Type: GrantFiled: November 8, 2013Date of Patent: February 24, 2015Assignee: Jacobus Pharmaceutical Company, Inc.Inventors: Gavin David Heffernan, David Penman Jacobus, Guy Alan Schiehser, Hong-Ming Shieh, Wenyi Zhao
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Publication number: 20140135360Abstract: The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.Type: ApplicationFiled: November 8, 2013Publication date: May 15, 2014Applicant: Jacobus Pharmaceutical Company, IncInventors: Gavin David Heffernan, David Penman Jacobus, Guy Alan Schiehser, Hong-Ming Shieh, Wenyi Zhao
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Publication number: 20140135320Abstract: The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.Type: ApplicationFiled: November 8, 2013Publication date: May 15, 2014Applicant: Jacobus Pharmaceutical Company, Inc.Inventors: Gavin David Heffernan, David Penman Jacobus, Kurt William Saionz, Guy Alan Schiehser, Hong-Ming Shieh, Wenyi Zhao
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Patent number: 7563792Abstract: Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.Type: GrantFiled: June 27, 2007Date of Patent: July 21, 2009Assignee: Jacobus Pharmaceutical Company, Inc.Inventors: David P. Jacobus, Guy A. Schiehser, Hong-Ming Shieh, Norman P. Jensen, Jacek Terpinski
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Patent number: 7494663Abstract: The present invention relates to the use of compounds of formula (I), wherein R is C1-C8-alkyl, unsubstituted or substituted with 1, 2 or 3 radicals selected from the group consisting of halogen, amino, nitro, cyano, C1-C4-alkenyl, C1-C4-haloalkenyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, 5- to 10-membered heteroaryl containing as ring members 1, 2, 3 or 4 heteroatoms selected from oxygen, sulfur and nitrogen, and phenyl, wherein the heteroaryl and phenyl radicals may be substituted for the control of nematodes, a method for the control of nematodes, and a method for the protection of plants from infestation or attack by nematodes.Type: GrantFiled: November 21, 2003Date of Patent: February 24, 2009Assignee: BASF AktiengesellschaftInventors: Markus Kordes, Wolfgang von Deyn, Michael Hofmann, Thomas Schmidt, Gerd Steiner, Michael F. Treacy, Henry Van Tuyl Cotter, Deborah L. Culbertson, Hong-Ming Shieh
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Publication number: 20080176852Abstract: Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.Type: ApplicationFiled: June 27, 2007Publication date: July 24, 2008Inventors: David P. Jacobus, Guy A. Schiehser, Hong-Ming Shieh, Norman P. Jensen, Jacek Terpinski
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Publication number: 20080064730Abstract: The present invention relates to new azine compounds which are useful combating animal pests, in particular insects and nematodes and to the salts thereof. The invention also relates to a method for combating insects, nematodes and arachnids. The azine compounds of the invention are described by the general formula (I) wherein . . . is absent or a covalent bond; n is 0 or 1, in particular 0; A is an optionally substituted cyclic radical selected from phenyl and a 5- or 6-membered heterocyclic radical with 1, 2, 3, or 4 heteroatoms; Ar is an optionally substituted aromatic radical selected from phenyl, pyridyl, pyrimidyl, furyl and thienyl, x is selected from halogen, OR7, SR7, SOR7, SO2R7, C1-C4-alkyl and C1-C4-haloalkyl; and wherein R1 to R4 and R7 are as described in the claims and the specification.Type: ApplicationFiled: November 25, 2005Publication date: March 13, 2008Applicant: BASF AktiengesellschaftInventors: Michael Hofmann, Ernst Baumann, Wolfgang von Deyn, Markus Kordes, Livio Tedeschi, Michael Treacy, Deborah Culbertson, Toni Bucci, Hong-Ming Shieh, Robert Arotin, Nicole Johnson
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Patent number: 7256218Abstract: Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.Type: GrantFiled: November 18, 2003Date of Patent: August 14, 2007Assignee: Jacobus Pharmaceutical Company, Inc.Inventors: David P. Jacobus, Guy A. Schiehser, Hong-Ming Shieh, Norman P. Jensen, Jacek Terpinski
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Publication number: 20070066627Abstract: The present invention relates to a method for combating insects or arachnids which comprises contacting the insects or the arachnids, their habitat, breeding ground, food supply, plant, seed, soil, area, material or environment in which the insects or the arachnids are growing or may grow, or the materials, plants, seeds, soils, surfaces or spaces to be protected from insect or arachnid attack or infestation with a pesticidally effective amount of a compound of the general formula (I) or a salt thereof wherein: Ar is a cyclic radical, n is 0 or 1, X is CO or SO2 and R1 to R4 are as defined in claim 1.Type: ApplicationFiled: May 26, 2004Publication date: March 22, 2007Inventors: Michael Hofmann, Markus Kordes, Udo Lange, Ernst Baumann, Wolfgang von Deyn, Michael Puhl, Thomas Schmidt, Gerd Steiner, Michael Treacy, Deborah Culbertson, Toni Bucci, Hong-Ming Shieh, Lester Maravetz
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Publication number: 20060052442Abstract: The present invention relates to the use of compounds of formula (I), wherein R is C1-C8-alkyl, unsubstituted or substituted with 1, 2 or 3 radicals selected from the group consisting of halogen, amino, nitro, cyano, C1-C4-alkenyl, C1-C4-haloalkenyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, 5- to 10-membered heteroaryl containing as ring members 1, 2, 3 or 4 heteroatoms selected from oxygen, sulfur and nitrogen, and phenyl, wherein the heteroaryl and phenyl radicals may be substituted for the control of nematodes, a method for the control of nematodes, and a method for the protection of plants from infestation or attack by nematodes.Type: ApplicationFiled: November 21, 2003Publication date: March 9, 2006Inventors: Markus Kordes, Wolfgang Deyn, Michael Hofmann, Thomas Schmidt, Gerd Steiner, Michael Treacy, Henry Cotter, Deborah Culbertson, Hong-Ming Shieh
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Publication number: 20040116428Abstract: Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.Type: ApplicationFiled: November 18, 2003Publication date: June 17, 2004Inventors: David P. Jacobus, Guy A. Schiehser, Hong-Ming Shieh, Norman P. Jensen, Jacek Terpinski
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Patent number: 6010999Abstract: The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing said derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.Type: GrantFiled: June 2, 1995Date of Patent: January 4, 2000Assignee: American Cyanamid CompanyInventors: Michael Joseph Daley, Brian Lee Buckwalter, Susan Mancini Cady, Hong-Ming Shieh, Peter Bohlen, Andrew P. Seddon
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Patent number: 5951972Abstract: The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing the derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.Type: GrantFiled: February 6, 1995Date of Patent: September 14, 1999Assignee: American Cyanamid CompanyInventors: Michael Joseph Daley, Brian Lee Buckwalter, Susan Mancini Cady, Hong-Ming Shieh, Peter Bohlen, Andrew P. Seddon
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Patent number: 5912325Abstract: An isolated polypeptide corresponding to the epitope of porcine somatotropin is provided by this invention as well as methods of enhancing the growth of an animal by administering to the animal this polypeptide in compositions.Type: GrantFiled: April 5, 1994Date of Patent: June 15, 1999Assignee: American Cyanamid CompanyInventors: Bosco Shang Wang, Hong-Ming Shieh, Martin John Corbett
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Patent number: 5338836Abstract: An isolated polypeptide corresponding to the epitope of porcine somatotropin is provided by this invention as well as methods of enhancing the growth of an animal by administering to the animal this polypeptide in compositions.Type: GrantFiled: July 29, 1992Date of Patent: August 16, 1994Assignee: American Cyanamid CompanyInventors: Bosco S. Wang, Hong-Ming Shieh, Martin J. Corbett
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Patent number: 5331094Abstract: The invention relates to a purified somatostatin receptor which is purified at least about 30,000-fold over the receptor which is membrane-bound. The invention also provides pharmaceutical compositions containing the receptor and antibodies to the receptor.Type: GrantFiled: October 19, 1992Date of Patent: July 19, 1994Assignee: American Cyanamid CompanyInventors: Cecil M. Eppler, John R. Zysk, Martin J. Corbett, Hong-Ming Shieh
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Patent number: 5225543Abstract: The receptor:ligand complex is applied to a solid phase substrate which binds the complex by specifically binding the ligand. The receptor is dissociated from the substrate bound receptor:ligand complex with an eluant capable of releasing the receptor from the ligand and leaving the ligand bound to the solid phase substrate. GTP containing eluants are effective. The receptor is recovered from the eluate and optionally subjected to further purification.Type: GrantFiled: March 28, 1991Date of Patent: July 6, 1993Assignee: American Cyanamid CompanyInventors: Cecil M. Eppler, Hong-Ming Shieh, John R. Zysk, Martin J. Corbett