Abstract: Methods and systems for attaching a radiopaque marker to a prosthetic heart valve to indicate a location of a commissure of the prosthetic heart valve are disclosed. As one example, a prosthetic heart valve includes a frame including a plurality of struts forming a plurality of cells of the frame arranged between an inflow end and an outflow end of the frame, a plurality of leaflets arranged within the frame, and at least one commissure comprising an attachment member arranged across a selected cell of the plurality of cells of the frame and commissure tabs of two adjacent leaflets coupled to the attachment member. The valve further includes a radiopaque marker arranged on the attachment member of the commissure within the selected cell.

Abstract: This disclosure relates to a surgical lighting device for generating a spot of light on a surgical site for use in combination with a fluorescence imaging device. The lighting device comprises a support structure, a subsurface which may be coupled to the support structure to seal the lower surface of the device while allowing light to pass through and a plurality of light sources emitting white light and placed between the support structure and the subsurface. The device further includes a plurality of NIR (near infrared) filters, each NIR filter being associated with a light source and being configured to substantially prevent the transmission of wavelengths within a wavelength band from 680 nm to 900 nm, while minimizing the change in the color temperature of the light spot.

Abstract: Method for providing a natural colour and optical depth to a dental object comprising the steps: providing a framework of the dental object, taking an object colour picture of an adjacent dental object or reference dental object, and uploading the object colour picture into a computing device, calibrating and adjusting the uploaded object colour picture into a target object colour picture in a computing device, (pre)determining the thickness profile of the enamel material to be applied on the framework, correcting in a computing device of the digital picture elements of the target object colour picture for the thickness profile of the enamel material to be applied on the position of the digital picture elements and providing a print colour picture of the corrected digital picture elements, printing the print colour picture as a print layer on the framework, applying the enamel material in the predetermined profile-thickness upon the print layer upon the framework.

Abstract: This disclosure relates to a surgical lighting device comprising a shell (12), a plurality of light sources (24) coupled to the shell, and a closure plate (18) for closing the lighting device by allowing light to pass through. The closure plate comprises a plurality of lens elements, each lens element being configured to collect and focus light from a corresponding light source to generate a light spot of a predetermined diameter located at a predetermined distance from the lighting device. In order to simplify the structure of the lighting device, the light sources and the cover plate are arranged in such a way that the light beams coming from the light sources and received by the associated lens elements arrive at the lens elements without substantial reflection or deflection. The closure plate therefore comprises all the optics necessary for collecting and focusing the light from the light sources.

Abstract: This disclosure relates to a surgical lighting device for generating a spot of light on a surgical site for use in combination with a fluorescence imaging device. The lighting device comprises a support structure, a subsurface which may be coupled to the support structure to seal the lower surface of the device while allowing light to pass through and a plurality of light sources emitting white light and placed between the support structure and the subsurface. The device further includes a plurality of NIR (near infrared) filters, each NIR filter being associated with a light source and being configured to substantially prevent the transmission of wavelengths within a wavelength band from 680 nm to 900 nm, while minimizing the change in the color temperature of the light spot.

Abstract: A system for analyzing a wound fluid. The system includes a transparent layer, a membrane layer, and an indicator layer that contains a colorimetric or fluorescent indicator reagent for detecting pH, a nitrite, an enzyme, a reactive oxygen species, a reactive nitrogen species, a nucleic acid, or a combination thereof. The membrane layer is impermeable to blood clots and cellular debris and is permeable to wound fluid. Also provided are methods for analyzing a wound fluid and for detecting biological fluid on biomedical instruments and waste materials using the system.

Abstract: Method for providing a natural colour and optical depth to a dental object comprising the steps: providing a framework of the dental object, taking an object colour picture of an adjacent dental object or reference dental object, and uploading the object colour picture into a computing device, calibrating and adjusting the uploaded object colour picture into a target object colour picture in a computing device, (pre)determining the thickness profile of the enamel material to be applied on the framework, correcting in a computing device of the digital picture elements of the target object colour picture for the thickness profile of the enamel material to be applied on the position of the digital picture elements and providing a print colour picture of the corrected digital picture elements, printing the print colour picture as a print layer on the framework, applying the enamel material in the predetermined profile-thickness upon the print layer upon the framework.

Abstract: A system for analyzing a wound fluid. The system includes a transparent layer, a membrane layer, and an indicator layer that contains a colorimetric or fluorescent indicator reagent for detecting pH, a nitrite, an enzyme, a reactive oxygen species, a reactive nitrogen species, a nucleic acid, or a combination thereof. The membrane layer is impermeable to blood clots and cellular debris and is permeable to wound fluid. Also provided are methods for analyzing a wound fluid and for detecting biological fluid on biomedical instruments and waste materials using the system.

Abstract: A lighting device comprises a solid optical collimator (6?), the collimator comprises a truncated cap having an inside surface (10?) operating in total internal reflection and having a small base opening into a frustoconical through recess that is coaxial with the cap and at the centre of which a light source (8?) is placed, and having a refractive large base such that incident light emitted by the light source is guided in totality by the inside surface towards the large base of the cap. The recess of the collimator is disposed in the cap in such a manner as to have a small base open and coinciding with the small base of the cap.

Abstract: A lighting device for illuminating an operative field comprises, in an axial lighting dome, a first ring of LEDs at a first color temperature, and a second ring of LEDs at a second color temperature different from said first color temperature, and an annular facetted mirror having semi-reflective facets and arranged about the same axis as said rings of LEDs. Collimation optical systems are provided between each ring of LEDs and the annular facetted mirror having semi-reflective facets. The annular facetted mirror having semi-reflective facets mixes the collimated light beams emitted by the two rings of LEDs coupled to the collimators, and forms first and second collimated resulting mixed light beams having the same intermediate color temperature.

Abstract: A lighting device comprises a solid optical collimator (6?), the collimator comprises a truncated cap having an inside surface (10?) operating in total internal reflection and having a small base opening into a frustoconical through recess that is coaxial with the cap and at the centre of which a light source (8?) is placed, and having a refractive large base such that incident light emitted by the light source is guided in totality by the inside surface towards the large base of the cap. The recess of the collimator is disposed in the cap in such a manner as to have a small base open and coinciding with the small base of the cap.

Abstract: The disclosure provides binding molecules, e.g., antibodies or antigen-binding fragments thereof, that can bind to orthologous epitopes found on two or more filovirus species or strains.

Abstract: A lighting device for illuminating an operative field comprises, in an axial lighting dome, a first ring of LEDs at a first color temperature, and a second ring of LEDs at a second color temperature different from said first color temperature, and an annular facetted mirror having semi-reflective facets and arranged about the same axis as said rings of LEDs. Collimation optical systems are provided between each ring of LEDs and the annular facetted mirror having semi-reflective facets. The annular facetted mirror having semi-reflective facets mixes the collimated light beams emitted by the two rings of LEDs coupled to the collimators, and forms first and second collimated resulting mixed light beams having the same intermediate color temperature.

Abstract: An LED lighting device comprises first and second LEDs arranged to respectively emit first and second beams of white light having first and second different respective colour temperatures, and a beam splitter arranged to split the first and second light beams respectively into a first reflected portion of the first and second beams and a second transmitted portion of the first and second beams. The LED's and the beam splitter are arranged spatially such that the transmitted portion of the first beam and the reflected portion of the second beam overlap into a first resulting beam of intermediate colour temperature between the first and second colour temperatures, and the reflected portion of the first beam and the transmitted portion of the second beam overlap into a second resulting beam of the same intermediate colour temperature.

Abstract: A lighting device comprises a first light source (10) at a first color temperature (Tk1), a second light source (20) at a second color temperature (Tk2) that is different from the first color temperature, and an optical system that forms an illumination spot (3) at an intermediate color temperature (Tkr). The optical system comprises a beam splitter (13) that is arranged to split the light produced by each light source (10, 20) into a transmitted light beam and a reflected light beam. It is arranged to focus said transmitted and reflective light beams (FR1, FR2) and to combine them in a certain superposition configuration in a superposition plane in which said illumination spot is formed, and the optical system and the light sources are arranged to modify the size of the illumination spot (3) at said intermediate temperature.

Abstract: A lighting device comprises a first light source (10) at a first color temperature (Tk1), a second light source (20) at a second color temperature (Tk2) that is different from the first color temperature, and an optical system that forms an illumination spot (3) at an intermediate color temperature (Tkr). The optical system comprises a beam splitter (13) that is arranged to split the light produced by each light source (10, 20) into a transmitted light beam and a reflected light beam. It is arranged to focus said transmitted and reflective light beams (FR1, FR2) and to combine them in a certain superposition configuration in a superposition plane in which said illumination spot is formed, and the optical system and the light sources are arranged to modify the size of the illumination spot (3) at said intermediate temperature.

Abstract: A window lifter comprises a cable, a window linkage driven by the cable, a fixed device and a cable redirecting device. The cable redirecting device is rotatably mounted on the fixed device and adapted to automatically lock onto the fixed device upon reaching a predetermined angular position. In addition, the cable redirecting device has a cable guiding portion which is not a figure of revolution about the axis of rotation relative to the fixed device. This window lifting mechanism provides a simple structure with few elements. Its assembly is also simple: the cable-redirecting device is rotatably mounted on the fixed device; it is thereafter rotated for tensioning the cable and then locked in a position where the cable is tensioned.

Abstract: A window lifter comprises a cable, a window linkage driven by the cable, a fixed device and a cable redirecting device. The cable redirecting device is rotatably mounted on the fixed device and adapted to automatically lock onto the fixed device upon reaching a predetermined angular position. In addition, the cable redirecting device has a cable guiding portion which is not a figure of revolution about the axis of rotation relative to the fixed device. This window lifting mechanism provides a simple structure with few elements. Its assembly is also simple: the cable-redirecting device is rotatably mounted on the fixed device; it is thereafter rotated for tensioning the cable and then locked in a position where the cable is tensioned.