Patents by Inventor Honghai SONG
Honghai SONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220272827Abstract: An example particle therapy system includes a gantry having a beamline structure configured to direct a particle beam that is monoenergetic from an output of a particle accelerator towards an irradiation target, where the beamline structure includes magnetic bending elements to bend the particle beam along a length of the beamline structure; and an energy degrader downstream of the beamline structure relative to the particle accelerator, where the energy degrader is configured and controllable to change an energy of the particle beam prior to at least part of the particle beam reaching the irradiation target.Type: ApplicationFiled: February 18, 2022Publication date: August 25, 2022Applicant: Mevion Medical Systems, Inc.Inventors: Yan Zhang, Gerrit Townsend Zwart, James Cooley, Mark R. Jones, Honghai Song, Yan Liu, Xunjie Yu
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Publication number: 20190009902Abstract: A hypersonic aircraft having a homopolar motor with high temperature superconducting (HTS) non-insulated (NI) coil magnets is described. In some implementations, the HTS NI coil magnets can have a graded resistance design. In some implementations, the HTS NI coil magnets can include a series of stacked coils, each of the series of coils comprising multiple turns having turn-to-turn resistance, where the turn-to-turn resistance of the series of coils is graded coil-to-coil across the magnet. In some implementations, the HTS NI coil magnets can include an NI coil comprising multiple turns and two or more thermal barriers each disposed between two adjacent turns of the coil, where an electrically conductive portion of one of the thermal barriers does not overlap with an electrically conductive portion of a different adjacent one of the thermal barriers. Some implementations can include a disk-type homopolar motor/generator including one or more HTS NI coil magnets.Type: ApplicationFiled: June 15, 2017Publication date: January 10, 2019Inventors: Wan-Kan Chan, Yawei Wang, Honghai Song, Justin Schwartz
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Patent number: 9540331Abstract: The present invention discloses a preparation method of 2,3-dimethyl phenyl-1-trityl-imidazole-4-ketone. In accordance with this method, imidazole-4-ethyl formate is used as a raw material; ethyl formate is used for amino protection, 1-trityl-1H-imidazole-4-formic acid is obtained after basic hydrolysis; 1-trityl-1H-imidazole-4-formic acid and N,O-dimethylhydroxylamine hydrochloride are subjected to condensation so as to obtain N-methoxyl-N-methyl-1-trityl-1H-imidazole-4-formamide; and N-methoxyl-N-methyl-1-trityl-1H-imidazole-4-formamide and a Grignard reagent prepared by the reaction of 2,3-dimethylbromobenzene with magnesium are subjected to a Grignard reaction, and then the target product 2,3-dimethyl phenyl-1-trityl-1H-imidazole-4-ketone is obtained. Compared with the reported preparation methods, the preparation method is more convenient to operate and is beneficial for industrial production.Type: GrantFiled: October 9, 2014Date of Patent: January 10, 2017Assignee: TIANJIN WEIJIE PHARMACEUTICAL CO., LTDInventors: Honghai Song, Zhicun Sun, Haiping Huang, Chao Zhang
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Publication number: 20160272594Abstract: The present invention discloses a preparation method of 2,3-dimethyl phenyl-1-trityl-imidazole-4-ketone. In accordance with this method, imidazole-4-ethyl formate is used as a raw material; ethyl formate is used for amino protection, 1-trityl-1H-imidazole-4-formic acid is obtained after basic hydrolysis; 1-trityl-1H-imidazole-4-formic acid and N,O-dimethylhydroxylamine hydrochloride are subjected to condensation so as to obtain N-methoxyl-N-methyl-1-trityl-1H-imidazole-4-formamide; and N-methoxyl-N-methyl-1-trityl-1H-imidazole-4-formamide and a Grignard reagent prepared by the reaction of 2,3-dimethylbromobenzene with magnesium are subjected to a Grignard reaction, and then the target product 2,3-dimethyl phenyl-1-trityl-1H-imidazole-4-ketone is obtained. Compared with the reported preparation methods, the preparation method is more convenient to operate and is beneficial for industrial production.Type: ApplicationFiled: October 9, 2014Publication date: September 22, 2016Inventors: Honghai SONG, Zhicun SUN, Haiping HUANG, Chao ZHANG
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Publication number: 20150141673Abstract: The present invention relates to a novel crystalline polymorph form W of cabazitaxel and to method for the preparation thereof.Type: ApplicationFiled: November 15, 2013Publication date: May 21, 2015Inventors: Honghai Song, Xingfeng Wang, Song Lin
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Patent number: 9018373Abstract: A method for preparing temsirolimus, the method including: using a substituted aromatic aldehyde to protect 2,2-dimethylol propionic acid to produce intermediate II; carrying out reaction between the intermediate II and 2,4,6-trichlorobenzoyl chloride; carrying out condensation reaction between a resulting product and rapamycin to produce intermediate III; and finally using sulfuric acid to remove a protecting group from the intermediate III to yield temsirolimus.Type: GrantFiled: July 3, 2013Date of Patent: April 28, 2015Assignee: Tianjin Weijie Technology Co., Ltd.Inventors: Honghai Song, Long Tang, Wei Chen, Zheng Li, Jinzhou Li, Zhicun Sun, Jiajin Feng
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Patent number: 8822678Abstract: A method for synthesizing temsirolimus, the method including: using a substituted boric acid to protect 2,2-dimethylol propionic acid to produce intermediate II; carrying out a reaction between the intermediate II and 2,4,6-trichlorobenzoyl chloride; carrying out condensation reaction between a resulting product and rapamycin to produce intermediate III; and finally using a diol to remove a protecting group from the intermediate III to yield temsirolimus.Type: GrantFiled: July 1, 2013Date of Patent: September 2, 2014Assignee: Tianjin Wiejie Technology Co., Ltd.Inventors: Honghai Song, Long Tang, Wei Chen, Zheng Li, Jinzhou Li, Zhicun Sun, Jiajin Feng
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Patent number: 8691844Abstract: A method for inhibiting coagulation including administering to a patient in need thereof a pharmaceutical composition containing 21-(S)-Argatroban and/or a pharmaceutically acceptable salt thereof. Compared with 21-(R)-Argatroban, 21-(S)-Argatroban significantly prolongs coagulation time of whole blood (CT), recalcification time (RT), kaolin partial thromboplastin time (APTT), pro-time prothrombin time (PT), thrombin time (TT), and reduces platelet adhesion rate and platelet aggregation rate in healthy dogs. Therefore, 21-(S)-Argatroban has a stronger effect for inhibiting coagulation and reducing therapeutically effective dose and is suitable for use in a method for treatment and/or prevention of thrombosis and inhibiting platelet aggregation.Type: GrantFiled: April 18, 2012Date of Patent: April 8, 2014Assignee: Tianjin Weijie Technology Co., Ltd.Inventor: Honghai Song
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Publication number: 20130296572Abstract: A method for preparing temsirolimus, the method including: using a substituted aromatic aldehyde to protect 2,2-dimethylol propionic acid to produce intermediate II; carrying out reaction between the intermediate II and 2,4,6-trichlorobenzoyl chloride; carrying out condensation reaction between a resulting product and rapamycin to produce intermediate III; and finally using sulfuric acid to remove a protecting group from the intermediate III to yield temsirolimus.Type: ApplicationFiled: July 3, 2013Publication date: November 7, 2013Inventors: Honghai SONG, Long TANG, Wei CHEN, Zheng LI, Jinzhou LI, Zhicun SUN, Jiajin FENG
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Publication number: 20130296550Abstract: A method for synthesizing temsirolimus, the method including: using a substituted boric acid to protect 2,2-dimethylol propionic acid to produce intermediate II; carrying out a reaction between the intermediate II and 2,4,6-trichlorobenzoyl chloride; carrying out condensation reaction between a resulting product and rapamycin to produce intermediate III; and finally using a diol to remove a protecting group from the intermediate III to yield temsirolimus.Type: ApplicationFiled: July 1, 2013Publication date: November 7, 2013Inventors: Honghai SONG, Long TANG, Wei CHEN, Zheng LI, Jinzhou LI, Zhicun SUN, Jiajin FENG
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Publication number: 20120202850Abstract: A method for inhibiting coagulation including administering to a patient in need thereof a pharmaceutical composition containing 21-(S)-Argatroban and/or a pharmaceutically acceptable salt thereof. Compared with 21-(R)-Argatroban, 21-(S)-Argatroban significantly prolongs coagulation time of whole blood (CT), recalcification time (RT), kaolin partial thromboplastin time (APTT), pro-time prothrombin time (PT), thrombin time (TT), and reduces platelet adhesion rate and platelet aggregation rate in healthy dogs. Therefore, 21-(S)-Argatroban has a stronger effect for inhibiting coagulation and reducing therapeutically effective dose and is suitable for use in a method for treatment and/or prevention of thrombosis and inhibiting platelet aggregation.Type: ApplicationFiled: April 18, 2012Publication date: August 9, 2012Applicant: TIANJIN WEIJIE TECHNOLOGY CO., LTD.Inventor: Honghai SONG
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Publication number: 20100016356Abstract: A method for inhibiting coagulation including administering to a patient in need thereof a pharmaceutical composition having 21-(S)-Argatroban and/or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for inhibiting coagulation having 21-(S)-Argatroban and/or a pharmaceutically acceptable salt thereof. Compared with 21 (R) Argatroban, 21-(S)-Argatroban significantly prolongs coagulation time of whole blood (CT), recalcification time (RT), kaolin partial thromboplastin time (APTT), pro-time prothrombin time (PT), thrombin time (TT), and reduces platelet adhesion rate and platelet aggregation rate in healthy dogs. Therefore, 21-(S)-Argatroban has a stronger effect of inhibiting coagulation and reducing therapeutically effective dose and is suitable for treatment and/or prevention of thrombosis and inhibiting platelet aggregation.Type: ApplicationFiled: September 24, 2009Publication date: January 21, 2010Applicant: TIANJIN WEIJIE TECHNOLOGY CO., LTD.Inventor: Honghai SONG