Patents by Inventor Hongjiang Wu

Hongjiang Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human RNase III and compositions and uses thereof
    Publication number: 20040126867
    Abstract: The present invention provides polynucleotides encoding human RNAse III and polypeptides encoded thereby. Methods of using said polynucleotides and polypeptides are also provided.
    Type: Application
    Filed: February 9, 2004
    Publication date: July 1, 2004
    Inventors: Stanley T. Crooke, HongJiang Wu
  • Human RNase H1 and oligonucleotide compositions thereof
    Publication number: 20040102618
    Abstract: The present invention provides oligonucleotides that can serve as substrates for human Type 2 RNase H. The present invention is also directed to methods of using these oligonucleotides in enhancing antisense oligonucleotide therapies.
    Type: Application
    Filed: July 8, 2003
    Publication date: May 27, 2004
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Stanley T. Crooke, Walter F. Lima, Hongjiang Wu
  • Human RNase III and compositions and uses thereof
    Patent number: 6737512
    Abstract: The present invention provides polynucleotides encoding human RNAse III and polypeptides encoded thereby. Methods of using said polynucleotides and polypeptides are also provided.
    Type: Grant
    Filed: July 6, 2001
    Date of Patent: May 18, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Hongjiang Wu, Stanley T. Crooke
  • Nuclease-based method for detecting and quantitating oligonucleotides
    Publication number: 20040005618
    Abstract: A method for quantitating an oligonucleotide in a sample of bodily fluid and/or extract is provided. The method provides for the detection and/or localization of oligonucleotides, including administered modified oligonucleotides, for therapeutic and/or pharmacokinetic purposes.
    Type: Application
    Filed: May 27, 2003
    Publication date: January 8, 2004
    Inventors: Zhengrong Yu, Brenda F. Baker, Hongjiang Wu
  • Human Rnase H1 and oligonucleotide compositions thereof
    Patent number: 6617442
    Abstract: The present invention provides oligonucleotides that can serve as substrates for human Type 2 RNase H. The present invention is also directed to methods of using these oligonucleotides in enhancing antisense oligonucleotide therapies.
    Type: Grant
    Filed: September 30, 1999
    Date of Patent: September 9, 2003
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Stanley T. Crooke, Walter F. Lima, Hongjiang Wu, Muthiah Monoharan
  • Human RNase H and compositions and uses thereof
    Publication number: 20030144496
    Abstract: The present invention provides polynucleotides and polypeptides encoded thereby of human Type 2 RNase H. Methods of using these polynucleotides and polypeptides in enhancing antisense oligonucleotide therapies are also provided.
    Type: Application
    Filed: February 3, 2003
    Publication date: July 31, 2003
    Inventors: Stanley T. Crooke, Walter Lima, Hongjiang Wu
  • Human RNase III and compositions and uses thereof
    Publication number: 20020164601
    Abstract: The present invention provides polynucleotides encoding human RNAse III and polypeptides encoded thereby. Methods of using said polynucleotides and polypeptides are also provided.
    Type: Application
    Filed: July 6, 2001
    Publication date: November 7, 2002
    Inventors: Hongjiang Wu, Stanley T. Crooke
  • Human RNase H1 mutants
    Publication number: 20020160486
    Abstract: A human RNase H polypeptide and methods of use are provided.
    Type: Application
    Filed: November 14, 2001
    Publication date: October 31, 2002
    Inventors: Hongjiang Wu, Walter F. Lima, Stanley T. Crooke
  • Human RNase H and compositions and uses thereof
    Publication number: 20020110892
    Abstract: The present invention provides polynucleotides and polypeptides encoded thereby of human Type 2 RNase H. Methods of using these polynucleotides and polypeptides in enhancing antisense oligonucleotide therapies are also provided.
    Type: Application
    Filed: October 22, 2001
    Publication date: August 15, 2002
    Inventors: Stanley T. Crooke, Walter F. Lima, Hongjiang Wu
  • Human RNase H and compositions and uses thereof
    Publication number: 20020076712
    Abstract: The present invention provides polynucleotides and polypeptides encoded thereby of human Type 2 RNase H. Methods of using these polynucleotides and polypeptides in enhancing antisense oligonucleotide therapies are also provided.
    Type: Application
    Filed: May 18, 2001
    Publication date: June 20, 2002
    Inventors: Stanley T. Crooke, Walter Lima, Hongjiang Wu
  • Human RNase H and compositions and uses thereof
    Patent number: 6376661
    Abstract: The present invention provides polynucleotides and polypeptides encoded thereby of human Type 2 RNase H. Methods of using these polynucleotides and polypeptides in enhancing antisense oligonucleotide therapies are also provided.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: April 23, 2002
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Stanley T. Crooke, Walter F. Lima, Hongjiang Wu
  • Methods of using mammalian RNase H and compositions thereof
    Publication number: 20010044145
    Abstract: The present invention relates to methods for using mammalian RNase H and compositions thereof, particularly for reduction of a selected cellular RNA target via antisense technology.
    Type: Application
    Filed: March 5, 2001
    Publication date: November 22, 2001
    Inventors: Brett P. Monia, Phillip Dan Cook, Stanley T. Crooke, Walter Lima, Hongjiang Wu
  • Human type 2 RNase H
    Patent number: 6001653
    Abstract: The present invention provides polynucleotides and polypeptides encoded thereby of human Type 2 RNase H. Methods of using these polynucleotides and polypeptides in enhancing antisense oligonucleotide therapies are also provided.
    Type: Grant
    Filed: December 2, 1998
    Date of Patent: December 14, 1999
    Assignee: Isis Pharmaceuticals Inc.
    Inventors: Stanley T. Crooke, Walter F. Lima, Hongjiang Wu