Patents by Inventor Hongming Chen
Hongming Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9532955Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.Type: GrantFiled: June 20, 2016Date of Patent: January 3, 2017Assignees: Kala Pharmaceuticals, Inc., The Johns Hopkins UniversityInventors: Alexey Popov, Elizabeth M. Enlow, James Bourassa, Colin R. Gardner, Hongming Chen, Laura M. Ensign, Samuel K. Lai, Tao Yu, Justin Hanes, Ming Yang
-
Publication number: 20160364056Abstract: A display module and a display device are provided. The display module may comprise a first substrate; a second substrate disposed opposite to the first substrate; a backlight module disposed at a side of the first substrate facing away from the second substrate; a first electrode; a second electrode disposed opposite to the first electrode for force touch; an air-gap layer disposed between the first electrode and the second electrode, and disposed parallel to the first substrate; and a frame assembly having a receiving space for at least receiving the backlight module, wherein the frame assembly includes at least one through-hole interconnected to the air-gap layer.Type: ApplicationFiled: August 29, 2016Publication date: December 15, 2016Inventors: HONGMING CHEN, SHAOTING LIN, YUPING MA
-
Publication number: 20160287526Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.Type: ApplicationFiled: June 20, 2016Publication date: October 6, 2016Inventors: Alexey Popov, Elizabeth M. Enlow, James Bourassa, Colin R. Gardner, Hongming Chen, Laura M. Ensign, Samuel K. Lai, Tao Yu, Justin Hanes, Ming Yang
-
Publication number: 20160228358Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.Type: ApplicationFiled: November 2, 2013Publication date: August 11, 2016Applicant: Kala Pharmaceuticals, Inc.Inventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
-
Patent number: 9393212Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.Type: GrantFiled: June 5, 2015Date of Patent: July 19, 2016Assignee: Kala Pharmaceuticals, Inc.Inventors: Alexey Popov, Elizabeth Enlow, James Bourassa, Colin R Gardner, Hongming Chen, Laura M Ensign, Samuel K Lai, Tao Yu, Justin Hanes, Ming Yang
-
Patent number: 9393213Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.Type: GrantFiled: June 5, 2015Date of Patent: July 19, 2016Assignee: Kala Pharmaceuticals, Inc.Inventors: Alexey Popov, Elizabeth Enlow, James Bourassa, Colin R Gardner, Hongming Chen, Laura M Ensign, Samuel K Lai, Tao Yu, Justin Hanes, Ming Yang
-
Publication number: 20160039823Abstract: The present invention provides novel derivative of ?-lactam antibiotics, such as meropenem. The inventive compounds include compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. Also provided are particles (e.g., nanoparticles) and pharmaceutical compositions thereof that are mucus penetrating. The inventive particles and pharmaceutical compositions may be useful in delivering an inventive compound to the respiratory tract of a subject. The invention further provides methods of using and kits including the inventive compounds, particles thereof, and/or pharmaceutical compositions thereof for treating and/or preventing a pulmonary disease (e.g., a respiratory tract infection).Type: ApplicationFiled: March 14, 2014Publication date: February 11, 2016Applicant: KALA PHARMACEUTICALS, INC.Inventors: Winston Zapanta Ong, Pawel Wojciech Nowak, Jinsoo Kim, Elizabeth M Enlow, James Bourassa, Yen Cu, Alexey Popov, Hongming Chen
-
Publication number: 20150265543Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.Type: ApplicationFiled: June 5, 2015Publication date: September 24, 2015Applicants: THE JOHNS HOPKINS UNIVERSITY, KALA PHARMACEUTICALS, INC.Inventors: Alexey Popov, Elizabeth Enlow, James Bourassa, Colin R. Gardner, Hongming Chen, Laura M. Ensign, Samuel K. Lai, Tao Yu, Justin Hanes, Ming Yang
-
Publication number: 20150265542Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.Type: ApplicationFiled: June 5, 2015Publication date: September 24, 2015Applicants: THE JOHNS HOPKINS UNIVERSITY, KALA PHARMACEUTICALS, INC.Inventors: Alexey Popov, Elizabeth Enlow, James Bourassa, Colin R. Gardner, Hongming Chen, Laura M. Ensign, Samuel K. Lai, Tao Yu, Justin Hanes, Ming Yang
-
Patent number: 9056057Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.Type: GrantFiled: May 3, 2013Date of Patent: June 16, 2015Assignees: Kala Pharmaceuticals, Inc., The John Hopkins UniversityInventors: Alexey Popov, Elizabeth M. Enlow, James Bourassa, Colin R. Gardner, Hongming Chen, Laura M. Ensign, Samuel K. Lai, Tao Yu, Justin Hanes, Ming Yang
-
Publication number: 20150125539Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.Type: ApplicationFiled: November 2, 2013Publication date: May 7, 2015Applicant: Kala Pharmaceuticals, Inc.Inventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
-
Publication number: 20140350095Abstract: Equatorial 2,3-fluorinated glycosides compounds of formula (I) useful for the treatment or prophylaxis of viral infection, particularly viral influenza, the methods for their preparation, and their pharmaceutical compositions. The therapeutic effect is achieved via inhibition of viral neuraminidases.Type: ApplicationFiled: January 17, 2013Publication date: November 27, 2014Inventors: Stephen Withers, Hongming Chen, Ricardo Resende, Jennifer Lois Breschkin
-
Publication number: 20130323179Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.Type: ApplicationFiled: May 3, 2013Publication date: December 5, 2013Applicant: Johns Hopkins University, TheInventors: Alexey Popov, Elizabeth M. Enlow, James Bourassa, Colin R. Gardner, Hongming Chen, Laura M. Ensign, Samuel K. Lai, Tao Yu, Justin Hanes, Ming Yang
-
Patent number: 8362062Abstract: The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.Type: GrantFiled: December 24, 2003Date of Patent: January 29, 2013Assignee: McNeil-PPC, Inc.Inventors: Mark Tawa, Julius Remenar, Matthew L. Peterson, Örn Almarsson, Hector Guzman, Hongming Chen, Mark Oliveira
-
Patent number: 8335201Abstract: A call control method, a communication system, and relevant devices are provided so that communications can be implemented under different network conditions based on the same number. The method includes: receiving a call request of a calling terminal, where the call request carries a called terminal number; querying a Home Location Register (HLR) of a called terminal according to the called terminal number; obtaining a Supplementary Service Code (SS_Code) from the HLR, where the SS_Code carries a Mobile Station International ISDN Number (MSISDN)-based IP Multimedia Subsystem (IMS) service identifier; and triggering an Application Server (AS) to implement an MSISDN-based IMS service according to the MSISDN-based IMS service identifier. A communication system and relevant devices are also provided.Type: GrantFiled: June 25, 2010Date of Patent: December 18, 2012Assignee: Huawei Technologies Co., Ltd.Inventors: Zhiquan Yi, Hongming Chen, Guihua Li, Qingchun Shen
-
Patent number: 8270982Abstract: A method for switching call between a mobile terminal with the same number and a soft terminal includes: receiving the switching instruction information sent by the soft terminal user during the call between the soft terminal or the mobile terminal with the same number and the opposing user; confirming the type of the switching instruction information, and carrying out the switching performance between the mobile terminal with the same number and the soft terminal according to the type of the switching instruction information. A system and an equipment for switching call between a mobile terminal with the same number and a PC client are disclosed in the present invention.Type: GrantFiled: September 20, 2010Date of Patent: September 18, 2012Assignee: Huawei Technologies Co., Ltd.Inventors: Zhiquan Yi, Hongming Chen, Guihua Li, Yi Zhang
-
Patent number: 8133918Abstract: The present invention provides aqueous pharmaceutical compositions containing a lipophilic therapeutic agent. In particular, the invention provides aqueous pharmaceutical compositions containing the compound 2,6-diisopropylphenol (propofol). Preferred compositions of the invention contain propofol in the presence of at least one block copolymer (for example, P188 or another poloxamer) and a polyethylene glycol (PEG). Compositions of the invention are preferably sterile or are readily sterilized (e.g., by autoclaving) and are suitable for parenteral administration to any animal, including humans. The compositions are also chemically and physically stable over a wide range of environmental conditions and for extended periods of time.Type: GrantFiled: December 12, 2008Date of Patent: March 13, 2012Assignee: Janssen Biotech, Inc.Inventors: Zhong Zhang, Orn Almarsson, Hongming Chen
-
Publication number: 20110110298Abstract: A call control method, a communication system, and relevant devices are provided so that communications can be implemented under different network conditions based on the same number. The method includes: receiving a call request of a calling terminal, where the call request carries a called terminal number; querying a Home Location Register (HLR) of a called terminal according to the called terminal number; obtaining a Supplementary Service Code (SS_Code) from the HLR, where the SS_Code carries a Mobile Station International ISDN Number (MSISDN)-based IP Multimedia Subsystem (IMS) service identifier; and triggering an Application Server (AS) to implement an MSISDN-based IMS service according to the MSISDN-based IMS service identifier. A communication system and relevant devices are also provided.Type: ApplicationFiled: June 25, 2010Publication date: May 12, 2011Applicant: Huawei Technologies Co., Ltd.Inventors: Zhiquan YI, Hongming Chen, Guihua Li, Qingchun Shen
-
Patent number: 7915317Abstract: The present invention relates to aqueous pharmaceutical compositions comprising 2,6-diisopropylphenol (propofol). A composition of the present invention can comprise propofol and two or more excipients as an aqueous mixture. The propofol containing compositions are preferably sterile and are parenterally administered to any animal, including humans. The compositions are also chemically and physically stable over a wide range of environmental conditions.Type: GrantFiled: July 29, 2003Date of Patent: March 29, 2011Assignee: Transform Pharmaceuticals, Inc.Inventors: Zhong Zhang, Orn Almarsson, Hongming Chen
-
Publication number: 20110021200Abstract: A method for switching call between a mobile terminal with the same number and a soft terminal includes: receiving the switching instruction information sent by the soft terminal user during the call between the soft terminal or the mobile terminal with the same number and the opposing user; confirming the type of the switching instruction information, and carrying out the switching performance between the mobile terminal with the same number and the soft terminal according to the type of the switching instruction information. A system and an equipment for switching call between a mobile terminal with the same number and a PC client are disclosed in the present invention.Type: ApplicationFiled: September 20, 2010Publication date: January 27, 2011Applicant: HUAWEI TECHNOLOGIES CO., LTD.Inventors: Zhiquan YI, Hongming CHEN, Guihua LI, Yi ZHANG