Abstract: Disclosed is a compound of formula (I) or a pharmaceutically acceptable salt, prodrug, tautomer or stereoisomer, and solvate thereof. The compound can be applied to treatment of cancers and inflammations of mammals. Further disclosed are a preparation method for the compound of formula (I) and a pharmaceutical composition containing the compound.

Abstract: The present disclosure relates to a method and system for evaluating the macro resilience of offshore oil well control equipment. The method for evaluating the macro resilience of offshore oil well control equipment comprises six steps: determining the type and strength of external disaster; calculating the failure rate of components; calculating the recovery rate of the components; modeling the BN for a degradation process; modeling the BN for a maintenance process; and calculating the resilience of the offshore oil well control equipment. A system for evaluating the macro resilience of offshore oil well control equipment comprises an external disaster evaluation module, a component failure rate calculation subsystem, a reliability degradation process simulation module, a fault identification module, a component recovery rate calculation module, a reliability recovery process simulation module, a reliability change curve derivation unit and an resilience calculation unit.

Abstract: A positioning method of functional rotation center of shoulder based on rigid upper arm model includes: step 1: abstracting a human upper arm into a cylinder with FRCS as a center of top surface; step 2: determining a reference axis vector of the cylinder; step 3: determining an axis vector of the cylinder and a displacement from the reference axis vector to the axis vector; step 4: correcting a central axis direction of the cylinder; step 5: determining a height compensation of the cylinder, and positioning the FRCS. The method has higher accuracy for the positioning result of FRCS, the positioning result of FRCS has better stability relative to the upper arm and trunk, and can be used to establish a more accurate human digital dynamic model and predict more accurate human posture.

Abstract: A detecting method and a positioning analysis method of human functional joint rotation center are provided. The detecting method of human functional joint rotation center includes: step 11: in a continuous motion, a human functional joint rotation center FCR is abstracted as a center of a flexible ball; step 12: at any moment during a test, position coordinates of the center of the ball (i.e. FCR) at the moment are determined according to position coordinates of M1, M2 and M3, and then the motion trajectory of the FCR is obtained in the continuous motion; the positioning analysis method performs positioning analysis of joint positions based on morphological parameters collected by 3D scanning. The detecting method is based on an idea of flexible ball, its operation is simple within a certain error range, and the method performs very well in the continuity of trajectory of joint.

Abstract: A detecting method and a positioning analysis method of human functional joint rotation center are provided. The detecting method of human functional joint rotation center includes: step 11: in a continuous motion, a human functional joint rotation center FCR is abstracted as a center of a flexible ball; step 12: at any moment during a test, position coordinates of the center of the ball (i.e. FCR) at the moment are determined according to position coordinates of M1, M2 and M3, and then the motion trajectory of the FCR is obtained in the continuous motion; the positioning analysis method performs positioning analysis of joint positions based on morphological parameters collected by 3D scanning. The detecting method is based on an idea of flexible ball, its operation is simple within a certain error range, and the method performs very well in the continuity of trajectory of joint.

Abstract: A positioning method of functional rotation center of shoulder based on rigid upper arm model includes: step 1: abstracting a human upper arm into a cylinder with FRCS as a center of top surface; step 2: determining a reference axis vector of the cylinder; step 3: determining an axis vector of the cylinder and a displacement from the reference axis vector to the axis vector; step 4: correcting a central axis direction of the cylinder; step 5: determining a height compensation of the cylinder, and positioning the FRCS. The method has higher accuracy for the positioning result of FRCS, the positioning result of FRCS has better stability relative to the upper arm and trunk, and can be used to establish a more accurate human digital dynamic model and predict more accurate human posture.

Abstract: The present disclosure belongs to the field of marine engineering, and in particular relates to a method and system for guaranteeing the safety of offshore oil well control equipment. The method comprises: identifying the state of a main structure of the offshore oil well control equipment, identifying the state of a hydraulic control unit of offshore oil well control equipment, identifying the state of an electronic control unit of offshore oil well control equipment, predicting the state of the offshore oil well control equipment and making a real-time decision based on existing information; and the system for guaranteeing the safety of the offshore oil well control equipment comprises a state identification subsystem of a main structure, a state identification subsystem of the hydraulic control unit, a state identification subsystem of the electronic control unit and a state prediction and real-time decision subsystem.

Abstract: The present disclosure belongs to the field of offshore oil, and in particular relates to a method for assessing the safety integrity level of offshore oil well control equipment. The method for assessing the safety integrity level of the offshore oil well control equipment comprises three major steps: creating a safety instrumented function evaluation module and dividing the related devices for performing the safety instrumented functions into a sensor subsystem; a controller subsystem and an actuator subsystem, establishing a dynamic Bayesian network model for respective subsystems for calculation; and integrating, analyzing and optimizing the safety integrity data of the subsystems.

Abstract: The present disclosure belongs to the field of petroleum engineering, in particular to a fully-electrically driven downhole safety valve. The fully-electrically driven downhole safety valve comprises a downhole safety valve mechanism and a downhole safety valve control system; wherein the downhole safety valve mechanism includes an electronic cabin module, a transmission control module, a motion conversion module, a magnetic coupling and spring module. and a valve module; the downhole safety valve control system includes a downhole comprehensive unit and an uphole comprehensive unit.

Abstract: The present disclosure relates to a method and system for evaluating the macro resilience of offshore oil well control equipment. The method for evaluating the macro resilience of offshore oil well control equipment comprises six steps: determining the type and strength of external disaster; calculating the failure rate of components; calculating the recovery rate of the components; modeling the BN for a degradation process; modeling the BN for a maintenance process; and calculating the resilience of the offshore oil well control equipment. A system for evaluating the macro resilience of offshore oil well control equipment comprises an external disaster evaluation module, a component failure rate calculation subsystem, a reliability degradation process simulation module, a fault identification module, a component recovery rate calculation module, a reliability recovery process simulation module, a reliability change curve derivation unit and an resilience calculation unit.

Abstract: The present disclosure belongs to the field of petroleum engineering, in particular to a fully-electrically driven downhole safety valve. The fully-electrically driven downhole safety valve comprises a downhole safety valve mechanism and a downhole safety valve control system; wherein the downhole safety valve mechanism includes an electronic cabin module, a transmission control module, a motion conversion module, a magnetic coupling and spring module. and a valve module; the downhole safety valve control system includes a downhole comprehensive unit and an uphole comprehensive unit.

Abstract: The present disclosure belongs to the field of offshore oil, and in particular relates to a method for assessing the safety integrity level of offshore oil well control equipment. The method for assessing the safety integrity level of the offshore oil well control equipment comprises three major steps: creating a safety instrumented function evaluation module and dividing the related devices for performing the safety instrumented functions into a sensor subsystem; a controller subsystem and an actuator subsystem, establishing a dynamic Bayesian network model for respective subsystems for calculation; and integrating, analyzing and optimizing the safety integrity data of the subsystems.

Abstract: The present disclosure belongs to the field of marine engineering, and in particular relates to a method and system for guaranteeing the safety of offshore oil well control equipment. The method comprises: identifying the state of a main structure of the offshore oil well control equipment, identifying the state of a hydraulic control unit of offshore oil well control equipment, identifying the state of an electronic control unit of offshore oil well control equipment, predicting the state of the offshore oil well control equipment and making a real-time decision based on existing information; and the system for guaranteeing the safety of the offshore oil well control equipment comprises a state identification subsystem of a main structure, a state identification subsystem of the hydraulic control unit, a state identification subsystem of the electronic control unit and a state prediction and real-time decision subsystem.

Abstract: The present invention relates to an apparatus and a method for measuring the dimensions of 1-dimensional and 0-dimensional nanostructures on semiconductor substrates in real-time during epitaxial growth. The method includes either assigning a pre-calculated 3D-model from a data base to the sample or calculating a 3D-model of the sample using the measured optical reflectances of the plurality of different measuring positions of the sample, where calculation or pre-calculation of the 3D-model includes calculation of the interference effects of light reflected from the front and back interfaces of the nano-structure and calculation of the interference effects due to superposition of neighbouring wave-fronts reflected from the nano-structure area and wave-fronts reflected from the substrate area between the nano-structures.