Abstract: The present disclosure provides a kit and method for constructing a long-acting depression animal model. The present disclosure adopts Bacille Calmette-Guerin (BCG) (or Mycobacterium bovis (M bovis)) and low-dose pertussis toxin (PTX) for combined induction, which greatly reduces modeling cost. A mouse model constructed by the method of the present disclosure can clearly distinguish a time interval of pathological behaviors from a time interval of depression-like behaviors and has prominent face validity and predictive validity. The method of the present disclosure is simple and convenient and does not require a large number of tedious daily operations as the depression model construction by chronic unpredictable stress, chronic restraint stress, social defeat, mother-child separation, or the like. The mouse model of the present disclosure can provide a valuable long-term intervention window for research on antidepressant therapy.

Abstract: A system for controlling an operation of an air-conditioning system including a heat exchanger is provided. The system comprises a processor that executes a neural network trained to simulate an operation of the heat exchanger for a test control input, to produce an output of the simulation based on historical data defining a state of the heat exchanger. The historical data includes a sequence of historical control inputs provided to the heat exchanger and a sequence of historical outputs of the operation of the heat exchanger corresponding to the sequence of historical control inputs. The processor determines a control command to the air-conditioning system based on the predicted test output of the simulation of the operation of the heat exchanger for the test control input and transmits the determined control command to an actuator of the air-conditioning system.

Abstract: A system for controlling an operation of an air-conditioning system including a heat exchanger is provided. The system comprises a processor that executes a neural network trained to simulate an operation of the heat exchanger for a test control input, to produce an output of the simulation based on historical data defining a state of the heat exchanger. The historical data includes a sequence of historical control inputs provided to the heat exchanger and a sequence of historical outputs of the operation of the heat exchanger corresponding to the sequence of historical control inputs. The processor determines a control command to the air-conditioning system based on the predicted test output of the simulation of the operation of the heat exchanger for the test control input and transmits the determined control command to an actuator of the air-conditioning system.

Abstract: A system for controlling or optimizing the performance of a vapor compression system by modifying the actuator commands via an output interface, that realizes thermofluid property functions and their derivatives as spline functions which are represented in a coordinate system that is aligned with a fluid saturation curve. The system includes an interface configured to receive measurement data from sensors, a memory configured to store thermofluid property data and computer-executable programs including a B-spline method, and a processor for performing the computer-implemented method. The processor is configured to take as input two thermofluid property variables, and compute a coordinate transformation in which one axis of the coordinates is aligned with the liquid and vapor saturation curves. In the saturation-curve aligned coordinates, a spline function represents the thermofluid property function, with coefficients and knots stored in memory.

Abstract: A simulation system for designing a heating ventilation and air conditioning (HVAC) system is provided. The system comprises an input interface configured to accept thermal data indicative of a target distribution of thermal state and environmental data, and a memory configured to store a building envelope model (BEM), an airflow dynamics model (ADM), and an HVAC model. The simulation system further comprises a processor configured to process the environmental data with the BEM to estimate thermal state of the air at the walls of the environment, and determine one or more design variables, by minimizing a multi-objective cost function. The simulation system further comprises an output interface configured to output the one or more design variables.

Abstract: A system for controlling or optimizing the performance of a vapor compression system by modifying the actuator commands via an output interface, that realizes thermofluid property functions and their derivatives as spline functions which are represented in a coordinate system that is aligned with a fluid saturation curve. The system includes an interface configured to receive measurement data from sensors, a memory configured to store thermofluid property data and computer-executable programs including a B-spline method, and a processor for performing the computer-implemented method. The processor is configured to take as input two thermofluid property variables, and compute a coordinate transformation in which one axis of the coordinates is aligned with the liquid and vapor saturation curves. In the saturation-curve aligned coordinates, a spline function represents the thermofluid property function, with coefficients and knots stored in memory.

Abstract: A control system for controlling an operation of a heating ventilation and air conditioning (HVAC) system is provided. The control system comprises an input interface configured to accept data indicative of a target distribution of thermal state in an environment, and a memory configured to store an airflow dynamics model (ADM) and an HVAC model. The control system further comprises a processor configured to inverse the ADM to estimate values of boundary conditions for inlet locations defining target thermal state at the inlet locations that result in the target distribution of thermal state in the environment; determine, using the HVAC model, target control parameters of actuators of the HVAC system resulting in the target thermal state at the inlet locations; and submit control commands to the HVAC system to operate the actuators of the HVAC system according to the control parameters.

Abstract: A control system for controlling an operation of a heating ventilation and air conditioning (HVAC) system is provided. The control system comprises an input interface configured to accept data indicative of a target distribution of thermal state in an environment, and a memory configured to store an airflow dynamics model (ADM) and an HVAC model. The control system further comprises a processor configured to inverse the ADM to estimate values of boundary conditions for inlet locations defining target thermal state at the inlet locations that result in the target distribution of thermal state in the environment; determine, using the HVAC model, target control parameters of actuators of the HVAC system resulting in the target thermal state at the inlet locations; and submit control commands to the HVAC system to operate the actuators of the HVAC system according to the control parameters.

Abstract: A simulation system for designing a heating ventilation and air conditioning (HVAC) system is provided. The system comprises an input interface configured to accept thermal data indicative of a target distribution of thermal state and environmental data, and a memory configured to store a building envelope model (BEM), an airflow dynamics model (ADM), and an HVAC model. The simulation system further comprises a processor configured to process the environmental data with the BEM to estimate thermal state of the air at the walls of the environment, and determine one or more design variables, by minimizing a multi-objective cost function. The simulation system further comprises an output interface configured to output the one or more design variables.

Abstract: Systems and methods for a vapor compression system including primary actuators, secondary actuators, primary sensors that provide a primary set of system outputs, and secondary sensors that provide a secondary set of system outputs. A primary controller receives the primary set of system outputs, and produces a primary set of control inputs for the primary actuators, to regulate one or more zone temperatures to set-points and to regulate one or more critical process variables to set-points. A secondary controller receives the secondary set of system outputs, and produces a secondary set of control inputs, to minimize an overall system power consumption. The secondary inputs may include set-points to the primary controller. The primary outputs may include estimates of critical process variables that are used as inputs to the secondary controller.

Abstract: A vapor compression system includes a heat transfer system including an arrangement of components moving a refrigerant through a vapor compression cycle to condition a controlled environment and a refrigerant management system including at least one expansion device regulating an amount of the refrigerant in the vapor compression cycle. The vapor compression system also includes a controller including a processor jointly controlling the expansion device and at least one component of the heat transfer system according to a metric of performance of the vapor compression system.

Abstract: Methods and systems for generating a diversification index for a portfolio are disclosed herein. A plurality of assets within the portfolio are identified, each of the plurality of assets having a corresponding weight value and a corresponding utility value. An overall volatility value of the portfolio is identified. A diversification index is computed based on the overall volatility value and corresponding weight and volatility values of each of the plurality of assets.

Abstract: Systems and methods for a vapor compression system including primary actuators, secondary actuators, primary sensors that provide a primary set of system outputs, and secondary sensors that provide a secondary set of system outputs. A primary controller receives the primary set of system outputs, and produces a primary set of control inputs for the primary actuators, to regulate one or more zone temperatures to set-points and to regulate one or more critical process variables to set-points. A secondary controller receives the secondary set of system outputs, and produces a secondary set of control inputs, to minimize an overall system power consumption. The secondary inputs may include set-points to the primary controller. The primary outputs may include estimates of critical process variables that are used as inputs to the secondary controller.

Abstract: A controller controls a first air-conditioning system and a second air-conditioning system having separate refrigerant circuits, but arranged for conditioning a common space. The controller includes a multi-variable regulator to determine control signals for controlling operations of first components of the first and the second refrigerant circuits to reduce jointly and concurrently an environmental error between setpoint and measured values of environment in the common space. The controller also includes at least two single-variable regulators to receive operational errors between setpoint and measured values of an operation of a second component of the first and the second refrigerant circuits. The controller separately determines control signals for controlling the operation of different refrigerant circuits that reduce the operational errors.

Abstract: A controller controls a first air-conditioning system and a second air-conditioning system having separate refrigerant circuits, but arranged for conditioning a common space. The controller includes a multi-variable regulator to determine control signals for controlling operations of first components of the first and the second refrigerant circuits to reduce jointly and concurrently an environmental error between setpoint and measured values of environment in the common space. The controller also includes at least two single-variable regulators to receive operational errors between setpoint and measured values of an operation of a second component of the first and the second refrigerant circuits. The controller separately determines control signals for controlling the operation of different refrigerant circuits that reduce the operational errors.

Abstract: A vapor compression system includes a heat transfer system including an arrangement of components moving a refrigerant through a vapor compression cycle to condition a controlled environment and a refrigerant management system including at least one expansion device regulating an amount of the refrigerant in the vapor compression cycle. The vapor compression system also includes a controller including a processor jointly controlling the expansion device and at least one component of the heat transfer system according to a metric of performance of the vapor compression system.

Abstract: To accommodate a transcritical vapor compression system with an operating envelope which covers a large range of heat source temperatures, a high side pressure is maintained at a level determined not only by operating conditions at the condenser but also at the evaporator. A control is provided to vary the expansion device in response to various combinations of refrigerant conditions sensed at both the condenser and the evaporator in order to maintain a desired high side pressure.

Abstract: To accommodate a transcritical vapor compression system with an operating envelope which covers a large range of heat source temperatures, a high side pressure is maintained at a level determined not only by operating conditions at the condenser but also at the evaporator. A control is provided to vary the expansion device in response to various combinations of refrigerant conditions sensed at both the condenser and the evaporator in order to maintain a desired high side pressure.