Patents by Inventor Hongtao Xu

Hongtao Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220017471
    Abstract: Disclosed herein are methods of labeling organic compounds without depending on any functional group of the compound. In some embodiments, provided are bifunctional linkers useful in the methods.
    Type: Application
    Filed: July 17, 2019
    Publication date: January 20, 2022
    Inventors: Guang Yang, Richard A. Lerner, Biao Jiang, Peixiang Ma, Hongtao Xu
  • Publication number: 20210371432
    Abstract: The present invention relates to compounds of formula (I), wherein R1 to R6, m and n are I a described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: June 3, 2019
    Publication date: December 2, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: FABIAN DEY, HONG SHEN, HONGTAO XU, HONGYING YUN, GE ZOU, WEI ZHU
  • Publication number: 20210340134
    Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds as antagonist of TLR7 and/or TLR8 and/or TLR9 in the treatment of autoimmune diseases as well as auto-inflammation diseases.
    Type: Application
    Filed: September 6, 2018
    Publication date: November 4, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zongxing Qiu, Hong Shen, Wei Zhu, Fabian Dey, Ge Zou, Hongtao Xu
  • Publication number: 20200168452
    Abstract: A method for planarizing a wafer surface comprising: providing a first wafer and a second wafer, oxidizing the first wafer to form an oxide layer on a surface of the first wafer, injecting a foaming ion to form a peeling layer in the first wafer, bonding the first wafer and the second wafer to form a bonded wafer by using the oxide layer as an intermediate layer, raising a temperature to cause the bonded wafer to crack in the peeling layer, a portion of the first wafer remaining on the surface of the oxide layer being a top silicon layer, and the oxide layer being an insulating buried layer, etching a surface of the top silicon layer with a mixed gas of hydrogen and HCl, wherein the mixed gas is injected from a side of the wafer, wherein a flow rate of the mixed gas in an edge region is less than a flow rate of the mixed gas in a central region.
    Type: Application
    Filed: October 14, 2019
    Publication date: May 28, 2020
    Applicant: Shanghai Simgui Technology Co., Ltd.
    Inventors: Xing WEI, Nan GAO, Meng CHEN, Xin SU, Hongtao XU
  • Publication number: 20200168501
    Abstract: A method for planarizing a wafer surface includes the following steps: providing a first wafer and a second wafer, oxidizing the first wafer to form an oxide layer on a surface of the first wafer, injecting a foaming ion to form a peeling layer in the first wafer, wherein an injection depth of the foaming ion is subject to the thickness of the oxide layer, bonding the first wafer and the second wafer to form a bonded wafer by using the oxide layer as an intermediate layer, raising a temperature to cause the bonded wafer to crack in the peeling layer, wherein a portion of the first wafer remaining on the surface of the oxide layer is a top silicon layer, and the oxide layer is an insulating buried layer; and annealing the bonded wafer.
    Type: Application
    Filed: October 9, 2019
    Publication date: May 28, 2020
    Applicant: Shanghai Simgui Technology Co., Ltd.
    Inventors: Xing WEI, Nan GAO, Meng CHEN, Xin SU, Hongtao XU
  • Publication number: 20200098703
    Abstract: The present disclosure provides a bonding method for a semiconductor substrate, which may improve flatness of a bonded substrate. The present disclosure further provides a bonded semiconductor substrate. The semiconductor substrate is thermally treated prior to bonding, and oxygen precipitates in the semiconductor substrate are partially or totally converted to interstitial oxygen atoms in the thermal treatment.
    Type: Application
    Filed: September 26, 2019
    Publication date: March 26, 2020
    Applicant: Shanghai Simgui Technology Co., Ltd.
    Inventors: Xing WEI, Xin SU, Hongtao XU, Meng CHEN, Nan GAO
  • Patent number: 10546420
    Abstract: Systems and methods for mesh generation for a model are disclosed. A mesh generation system may include a processing circuit configured to receive a surface geometry of a model, the surface geometry including more than one boundary node. The processing circuit is further configured to generate a finite element mesh of the model using the one or more boundary nodes of the surface geometry. The generation of the finite element mesh occurs via one of a mapped meshing method and a mapped seeding method. The mapped seeding method may be used when one or more fixed nodes are present in the model.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: January 28, 2020
    Assignee: MSC.SOFTWARE CORPORATION
    Inventors: Kunaseelan Kanthasamy, Hongtao Xu
  • Patent number: 10006063
    Abstract: The invention relates to the field of producing succinate by E. coli fermentation. Specifically, the invention provides an engineered recombinant E. coli for producing succinate, wherein said E. coli contains one or more of the following modifications: a) enhanced activity of the protein(s) encoded by the gene(s) involved in pentose phosphate pathway (PPP), b) enhanced activity of the protein encoded by sthA gene, and optionally c) mutant lpdA gene. The invention also relates to use of the engineered recombinant E. coli for producing succinate, and a method of using the engineered recombinant E. coli for producing succinate.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: June 26, 2018
    Assignee: TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Xueli Zhang, Xinna Zhu, Hongtao Xu, Zaigao Tan
  • Patent number: 9982142
    Abstract: This invention relates to a zinc-rich epoxy anti-corrosion coating comprising a component A capable of being cured into a film, and a component B containing a curing agent, wherein the component A comprises, by mass percentage, 0.1-5 wt % graphene, 0-35 wt % zinc powder, 30-70 wt % filler, 10-20 wt % epoxy resin having 54 wt % solid content, and 10-20 wt % solvent, wherein the sum of the mass percentage contents of the graphene, zinc powder and filler is 60-80 wt % and the sum of the mass percentage contents of all components of component A is 100 wt %. According to the present invention, the addition of graphene to an anti-corrosion coating decreases the thickness of the coating film, reduces the amount of zinc powder while increases the anti-corrosion effect. It reduces zinc oxide vapour generated during welding and is environmentally friendly.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: May 29, 2018
    Assignee: THE SIXTH ELEMENT (CHANGZHOU) METERIALS TECHNOLOGY CO., LTD.
    Inventors: Qiongxin Liu, Xiaolan Qu, Hongtao Xu, Yan Qu, Yufei Ma, Huailiang Xu, Zhenyu Tian
  • Patent number: 9944957
    Abstract: Provided is recombinant Escherichia coli comprising a mutated ldhA gene. Disclosed are use of the recombinant Escherichia coli in the preparation of D-lactate, and method of preparing D-lactate by employing the recombinant Escherichia coli. In the method of preparing D-lactate, fermentation can be conducted at a high temperature (42-50° C.), and aqueous ammonia or sodium hydroxide can be used as a neutralizer during the fermentation.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: April 17, 2018
    Assignee: TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Yanhe Ma, Xueli Zhang, Hongtao Xu, Xinna Zhu, Pingping Liu, Jinlei Tang
  • Patent number: 9877158
    Abstract: Embodiments of a mobile station and method for Wi-Fi scan scheduling and power adaption for low-power indoor location are generally described herein. In some embodiments, the mobile station may identify channels, beacon timing and rough signal strength levels of nearby access points (APs) from at least one of a previous full-channel scan or a Wi-Fi fingerprint database and may configure receiver sensitivity based on the rough signal strength levels for receipt of subsequent beacons. The mobile station may wake-up from a low-power state to receive beacons for the nearby access points on the identified channels at times based on the identified beacon timing. The received signal strength indicators (RSSIs) levels of the received beacons may be used for location determination.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: January 23, 2018
    Assignee: Intel Corporation
    Inventors: Lei Yang, Hongtao Xu, Xue Yang
  • Patent number: 9816124
    Abstract: Provided are a recombinant strain for preparing a terpenoid, and method for constructing the recombinant strain. Also provided is a recombinant bacterium 1, the recombinant bacterium 1 being a recombinant bacterium obtained in order to improve the enzymatic activity of ?-ketoglutarate dehydrogenase in escherichia coli or the mutant thereof. The method for improving the enzymatic activity of ?-ketoglutarate dehydrogenase in escherichia coli or the mutant thereof is replacing the original regulating element of the ketoglutarate dehydrogenase gene (sucAB) in escherichia coli or the mutant thereof with any of the following regulating elements: artificial regulating element M 1-46, M1-37, and M1-93. Also provided are a plurality of recombinant bacteria.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: November 14, 2017
    Assignee: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
    Inventors: Xueli Zhang, Qingyan Li, Jing Zhao, Tao Sun, Guanping Dai, Hongtao Xu, Jinlei Tang, Yanhe Ma
  • Patent number: 9515062
    Abstract: Apparatus having structures implementing compact and symmetric multi-way transformer combiners are described herein. In an embodiment, each unit device cell of a plurality unit device cells may include two metal layers on top of the unit device cell coupled to a multi-way transformer combiner by one of the two metal layers such that the configuration of the unit device cells with the multi-way transformer combiner is symmetric. Additional apparatus, systems, and methods are disclosed.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: December 6, 2016
    Assignee: Intel Corporation
    Inventors: Hongtao Xu, Georgios Palaskas
  • Publication number: 20160280931
    Abstract: This invention relates to a zinc-rich epoxy anti-corrosion coating comprising a component A capable of being cured into a film, and a component B containing a curing agent, wherein the component A comprises, by mass percentage, 0.1-5 wt % graphene, 0-35 wt % zinc powder, 30-70 wt % filler, 10-20 wt % epoxy resin having 54 wt % solid content, and 10-20 wt % solvent, wherein the sum of the mass percentage contents of the graphene, zinc powder and filler is 60-80 wt % and the sum of the mass percentage contents of all components of component A is 100 wt %. According to the present invention, the addition of graphene to an anti-corrosion coating decreases the thickness of the coating film, reduces the amount of zinc powder while increases the anti-corrosion effect. It reduces zinc oxide vapour generated during welding and is environmentally friendly.
    Type: Application
    Filed: May 5, 2014
    Publication date: September 29, 2016
    Inventors: Qiongxin LIU, Xiaolan QU, Hongtao XU, Yan QU, Yufei MA, Huailiang XU, Zhenyu TIAN
  • Publication number: 20160219408
    Abstract: Embodiments of a mobile station and method for Wi-Fi scan scheduling and power adaption for low-power indoor location are generally described herein. In some embodiments, the mobile station may identify channels, beacon timing and rough signal strength levels of nearby access points (APs) from at least one of a previous full-channel scan or a Wi-Fi fingerprint database and may configure receiver sensitivity based on the rough signal strength levels for receipt of subsequent beacons. The mobile station may wake-up from a low-power state to receive beacons for the nearby access points on the identified channels at times based on the identified beacon timing. The received signal strength indicators (RSSIs) levels of the received beacons may be used for location determination.
    Type: Application
    Filed: December 20, 2013
    Publication date: July 28, 2016
    Inventors: Lei Yang, Hongtao Xu, Xue Yang
  • Publication number: 20160181234
    Abstract: Apparatus having structures implementing compact and symmetric multi-way transformer combiners are described herein. In an embodiment, each unit device cell of a plurality unit device cells may include two metal layers on top of the unit device cell coupled to a multi-way transformer combiner by one of the two metal layers such that the configuration of the unit device cells with the multi-way transformer combiner is symmetric. Additional apparatus, systems, and methods are disclosed.
    Type: Application
    Filed: December 18, 2014
    Publication date: June 23, 2016
    Inventors: Hongtao Xu, Georgios Palaskas
  • Publication number: 20160145653
    Abstract: Provided is recombinant Escherichia coli comprising a mutated ldhA gene. Disclosed are use of the recombinant Escherichia coli in the preparation of D-lactate, and method of preparing D-lactate by employing the recombinant Escherichia coli. In the method of preparing D-lactate, fermentation can be conducted at a high temperature (42-50 ° C.), and aqueous ammonia or sodium hydroxide can be used as a neutralizer during the fermentation.
    Type: Application
    Filed: July 9, 2014
    Publication date: May 26, 2016
    Applicant: Tianjin Instutute of Industrial Biotechnology, Chinese Academy of Sciences
    Inventors: Yanhe MA, Xueli ZHANG, Hongtao XU, Xinna ZHU, Pingping LIU, Jinlei TANG
  • Publication number: 20160097064
    Abstract: The invention relates to the field of producing succinate by E. coli fermentation. Specifically, the invention provides an engineered recombinant E. coli for producing succinate, wherein said E. coli contains one or more of the following modifications: a) enhanced activity of the protein(s) encoded by the gene(s) involved in pentose phosphate pathway (PPP), b) enhanced activity of the protein encoded by sthA gene, and optionally c) mutant lpdA gene. The invention also relates to use of the engineered recombinant E. coli for producing succinate, and a method of using the engineered recombinant E. coli for producing succinate.
    Type: Application
    Filed: May 23, 2014
    Publication date: April 7, 2016
    Inventors: Xueli ZHANG, Xinna ZHU, Hongtao XU, Zaigao TAN
  • Patent number: D940380
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: January 4, 2022
    Inventor: Hongtao Xu
  • Patent number: D942670
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: February 1, 2022
    Inventor: Hongtao Xu