Patents by Inventor Hongxian He

Hongxian He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glucosyltransferase enzymes for production of glucan polymers
    Patent number: 9284539
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: March 15, 2016
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Mark S Payne, Yefim Brun, Hongxian He, Thomas Scholz
  • Glucosyltransferase enzymes for production of glucan polymers
    Patent number: 9284540
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: March 15, 2016
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Mark S. Payne, Yefim Brun, Hongxian He, Thomas Scholz
  • Peptide linkers for effective multivalent peptide binding
    Patent number: 9278138
    Abstract: Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: March 8, 2016
    Assignee: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Qiong Cheng, Stephen R. Fahnestock, Hongxian He, Kristy N. Kostichka, Hong Wang
  • Glucosyltransferase enzymes for production of glucan polymers
    Patent number: 9260701
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: February 16, 2016
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Mark S Payne, Yefim Brun, Hongxian He, Thomas Scholz
  • Glucosyltransferase enzymes for production of glucan polymers
    Patent number: 9260702
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: February 16, 2016
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Mark S Payne, Yefim Brun, Hongxian He, Thomas Scholz
  • Keto-isovalerate decarboxylase enzymes and methods of use thereof
    Patent number: 9238828
    Abstract: Provided herein are polypeptides and polynucleotides encoding such polypeptides which have ketoisovalerate decarboxylase activity. Also provided are recombinant host cells comprising such polypeptides and polynucleotides and methods of use thereof.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: January 19, 2016
    Assignee: Butamax Advanced Biofuels LLC
    Inventors: Jessica McElvain, Daniel P O'Keefe, Brian James Paul, Mark S Payne, Steven Cary Rothman, Hongxian He
  • Glucosyltransferase enzymes for production of glucan polymers
    Patent number: 9228177
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: January 5, 2016
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Mark S Payne, Yefim Brun, Hongxian He, Thomas Scholz
  • Glucosyltransferase enzymes for production of glucan polymers
    Patent number: 9228176
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: January 5, 2016
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Mark S Payne, Yefim Brun, Hongxian He, Thomas Scholz
  • Mutant delta-9 elongases and their use in making polyunsaturated fatty acids
    Patent number: 8980589
    Abstract: Mutant delta-9 elongases having the ability to convert linoleic acid [18:2, LA] to eicosadienoic acid [20:2, EDA] and/or ?-linolenic [18:3, ALA] to eicosatrienoic acid [20:3, ETrA] are disclosed herein. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding mutant delta-9 elongases, along with a method of making long chain polyunsaturated fatty acids [“PUFAs”] using these mutant delta-9 elongases in oleaginous yeast are also disclosed.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: March 17, 2015
    Assignee: E I du Pont de Nemours and Company
    Inventors: Michael W. Bostick, Hongxian He, Yougen Li, Quinn Qun Zhu
  • GLUCOSYLTRANSFERASE ENZYMES FOR PRODUCTION OF GLUCAN POLYMERS
    Publication number: 20150010956
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Application
    Filed: September 19, 2014
    Publication date: January 8, 2015
    Inventors: MARK S. PAYNE, Yefim Brun, Hongxian He, Thomas Scholz
  • GLUCOSYLTRANSFERASE ENZYMES FOR PRODUCTION OF GLUCAN POLYMERS
    Publication number: 20150010955
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Application
    Filed: September 19, 2014
    Publication date: January 8, 2015
    Inventors: MARK S. PAYNE, YEFIM BRUN, HONGXIAN HE, THOMAS SCHOLZ
  • GLUCOSYLTRANSFERASE ENZYMES FOR PRODUCTION OF GLUCAN POLYMERS
    Publication number: 20150010954
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Application
    Filed: September 19, 2014
    Publication date: January 8, 2015
    Inventors: MARK S. PAYNE, Yefim Brun, Hongxian He, Thomas Scholz
  • GLUCOSYLTRANSFERASE ENZYMES FOR PRODUCTION OF GLUCAN POLYMERS
    Publication number: 20150004652
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Application
    Filed: September 19, 2014
    Publication date: January 1, 2015
    Inventors: MARK S. PAYNE, Yefim Brun, Hongxian He, Thomas Scholz
  • GLUCOSYLTRANSFERASE ENZYMES FOR PRODUCTION OF GLUCAN POLYMERS
    Publication number: 20150004650
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Application
    Filed: September 19, 2014
    Publication date: January 1, 2015
    Inventors: MARK S. PAYNE, Yefim Brun, Hongxian He, Thomas Scholz
  • GLUCOSYLTRANSFERASE ENZYMES FOR PRODUCTION OF GLUCAN POLYMERS
    Publication number: 20150004651
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Application
    Filed: September 19, 2014
    Publication date: January 1, 2015
    Inventors: MARK S PAYNE, Yefim Brun, Hongxian He, Thomas Scholz
  • GLUCOSYLTRANSFERASE ENZYMES FOR PRODUCTION OF GLUCAN POLYMERS
    Publication number: 20150004653
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Application
    Filed: September 19, 2014
    Publication date: January 1, 2015
    Inventors: MARK S. PAYNE, Yefim Brun, Hongxian He, Thomas Scholz
  • GLUCOSYLTRANSFERASE ENZYMES FOR PRODUCTION OF GLUCAN POLYMERS
    Publication number: 20150004649
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Application
    Filed: September 19, 2014
    Publication date: January 1, 2015
    Inventors: MARK S. PAYNE, Yefim Brun, Hongxian He, Thomas Scholz
  • Glucosyltransferase enzymes for production of glucan polymers
    Patent number: 8871474
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: October 28, 2014
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Mark S Payne, Yefim Brun, Hongxian He, Thomas Scholz
  • PEPTIDE LINKERS FOR EFFECTIVE MULTIVALENT PEPTIDE BINDING
    Publication number: 20140241999
    Abstract: Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
    Type: Application
    Filed: February 27, 2014
    Publication date: August 28, 2014
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Qiong Cheng, Stephen R. Fahnestock, Hongxian He, Kristy N. Kostichka, Hong Wang
  • Peptide linkers for effective multivalent peptide binding
    Patent number: 8697654
    Abstract: Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: April 15, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Qiong Cheng, Stephen R. Fahnestock, Hongxian He, Kristy N. Kostichka, Hong Wang