Patents by Inventor Hongxing Yan

Hongxing Yan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LARGE-SIZE DIAMOND, MPCVD DEVICE AND PREPARATION METHOD OF LARGE-SIZE DIAMOND
    Publication number: 20240183067
    Abstract: MPCVD device comprises deposition platform, substrate platform, lifting platform, microwave quartz window, upper cover plate, baseplate, pressure sensors, composite windows, thickness measuring device, visual device, temperature measuring device, plasma diagnostic device, vacuum sealing ring and microwave shielding sealing ring. Reaction cavity is formed by upper cover plate and baseplate, and inlet hole is arranged on top of upper cover plate, while exhaust hole is arranged on baseplate; microwave quartz window is annular shaped and arranged between deposition platform and baseplate, and reaction cavity is isolated from air outside by microwave quartz window; lifting platform is provided with vacuum channel and cooling channel therein; vacuum cavity, which is communicated with vacuum channel, is formed by lower surface of substrate platform and upper surface of lifting platform; and pressure sensor for monitoring gas pressure is arranged in vacuum cavity.
    Type: Application
    Filed: March 30, 2023
    Publication date: June 6, 2024
    Inventors: Xiaolei Wu, Ning Yan, Shuai Xu, Yanjun Zhao, Junyong Shao, Wentao Zhou, Jiong Zhao, Bolun Cao, Hui Liu, Hongxing Pan
  • Nrf2 REGULATORS
    Publication number: 20230047296
    Abstract: The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Application
    Filed: October 6, 2021
    Publication date: February 16, 2023
    Inventors: Jeffrey K. KERNS, James Callahan, Hongxing Yan, Thomas Daniel Heightman, Charlotte Mary Griffiths-Jones, Alison Jo-Anne Woolford, Tindy Li, Ami Lakdawala Shah, Roderick S. Davis, David Norton, Jeffrey Charles Boehm, Paris L. Hamilton, Nicole Cathleen Goodwin, Yun Jin
  • ETHER LINKED TRIAZOLES AS NRF2 ACTIVATORS
    Publication number: 20220089590
    Abstract: The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators.
    Type: Application
    Filed: June 17, 2021
    Publication date: March 24, 2022
    Inventors: Anthony William James Cooper, Nicole Cathleen Goodwin, Charlotte Mary Griffiths-Jones, Thomas Daniel Heightman, Jeffrey K. Kerns, Hendrika Maria Gerarda Willems, Hongxing Yan
  • BISARYL LACTAMS AS NRF2 ACTIVATORS
    Publication number: 20220002272
    Abstract: The present invention relates to bisaryl lactam compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators.
    Type: Application
    Filed: December 11, 2017
    Publication date: January 6, 2022
    Inventors: Jeffrey Charles BOEHM, Roderick S. DAVIS, Nicole Cathleen GOODWIN, Jeffrey K. KERNS, Tindy LI, Hongxing YAN
  • Ether linked triazoles as NRF2 activators
    Patent number: 11059816
    Abstract: The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: July 13, 2021
    Assignees: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED, ASTEX THERAPEUTICS LIMITED
    Inventors: Anthony William James Cooper, Nicole Cathleen Goodwin, Charlotte Mary Griffiths-Jones, Thomas Daniel Heightman, Jeffrey K. Kerns, Hendrika Maria Gerarda Willems, Hongxing Yan
  • Nrf2 REGULATORS
    Publication number: 20200079759
    Abstract: The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Application
    Filed: November 6, 2019
    Publication date: March 12, 2020
    Inventors: Jeffrey K. KERNS, James Callahan, Hongxing Yan, Thomas Daniel Heightman, Charlotte Mary Griffiths-Jones, Alison Jo-Anne Woolford, Tindy Li, Ami Lakdawala Shah, Roderick S. Davis, David Norton, Jeffrey Charles Boehm, Paris L. Hamilton, Nicole Cathleen Goodwin, Yun Jin
  • ETHER LINKED TRIAZOLES AS NRF2 ACTIVATORS
    Publication number: 20200071317
    Abstract: The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators.
    Type: Application
    Filed: December 11, 2017
    Publication date: March 5, 2020
    Inventors: Anthony William James COOPER, Nicole Cathleen GOODWIN, Charlotte Mary GRIFFITHS-JONES, Thomas Daniel HEIGHTMAN, Jeffrey K. KERNS, Hendrika Maria Gerarda WILLEMS, Hongxing YAN
  • Nrf2 regulators
    Patent number: 10485806
    Abstract: The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: November 26, 2019
    Assignees: GlaxoSmithKline Intellectual Property Development Limited, Astex Therapeutics Limited
    Inventors: Jeffrey K. Kerns, James Francis Callahan, Hongxing Yan, Thomas Daniel Heightman, Jeffrey Charles Boehm, Alison Jo-Anne Woolford
  • Nrf2 REGULATORS
    Publication number: 20190224212
    Abstract: The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Application
    Filed: April 4, 2019
    Publication date: July 25, 2019
    Inventors: Jeffrey K. Kerns, James Francis Callahan, Hongxing Yan, Thomas Daniel Heightman, Jeffrey Charles Boehm, Alison Jo-Anne Woolford
  • NRF2 regulators
    Patent number: 10272095
    Abstract: The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: April 30, 2019
    Assignees: GlaxoSmithKline Intellectual Propert Development Limited, Astex Therapeutics, Limited
    Inventors: Jeffrey K. Kerns, James Francis Callahan, Hongxing Yan, Thomas Daniel Heightman, Jeffrey Charles Boehm, Alison Jo-Anne Woolford
  • NRF2 Regulators
    Publication number: 20190002454
    Abstract: The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
    Type: Application
    Filed: September 6, 2018
    Publication date: January 3, 2019
    Inventors: Jeffrey Charles BOEHM, Thomas Glanmor DAVIES, Alison Jo-Anne WOOLFORD, Charlotte Mary GRIFFITHS-JONES, Hendrika Maria Gerarda WILLEMS, David NORTON, Gordon SAXTY, Thomas Daniel HEIGHTMAN, Tindy LI, Jeffrey K. KERNS, Roderick S. DAVIS, Hongxing YAN
  • Nrf2 REGULATORS
    Publication number: 20180179167
    Abstract: The present invention relates to aryl analogs Formula (I), pharmaceutical compositions containing them and their use as Nrf2 regulators.
    Type: Application
    Filed: June 15, 2016
    Publication date: June 28, 2018
    Inventors: Jeffrey K. KERNS, Tindy LI, Hongxing YAN, Thomas Daniel HEIGHTMAN, Alison Jo-Anne WOOLFORD, Charlotte Mary GRIFFITHS-JONES, Hendrika Maria Gerarda WILLEMS
  • Nrf2 REGULATORS
    Publication number: 20180179187
    Abstract: Provided are aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Application
    Filed: June 15, 2016
    Publication date: June 28, 2018
    Inventors: Jeffrey K. KERNS, James CALLAHAN, Hongxing YAN, Thomas Daniel HEIGHTMAN, Charlotte Mary GRIFFITHS-JONES, Alison Jo-Anne WOOLFORD, Tindy LI, Ami Lakdawala SHAH, Roderick S. DAVIS, David NORTON, Jeffrey Charles BOEHM, Paris L. HAMILTON
  • Nrf2 REGULATORS
    Publication number: 20180169110
    Abstract: The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Application
    Filed: June 15, 2016
    Publication date: June 21, 2018
    Inventors: Jeffrey K. KERNS, Jamas Francis CALLAHAN, Hongxing YAN, Thomas Daniel HEIGHTMAN, Jeffrey Charles BOEHM, Alison Jo-Anne WOOLFORD
  • NRF2 REGULATORS
    Publication number: 20160318917
    Abstract: The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
    Type: Application
    Filed: December 17, 2014
    Publication date: November 3, 2016
    Inventors: Jeffrey Charles Boehm, Thomas Glanmor Davies, Alison Jo-anne Woolford, Charlotte Mary Griffiths-Jones, Hendrika Maria Gerarda Willems, David Norton, Gordon Saxity, Thomas Daniel Heightman, Tindy Li, Jeffrey K. Kerns, Roderick S. Davis, Hongxing Yan
  • Dual pharmacophores—PDE4-muscarinic antagonistics
    Patent number: 8084449
    Abstract: The present invention is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions and their use as dual chromaphores having inhibitory activity against PDE4 and muscarinic acetylcholine receptors (mAChRs), and thus being useful for treating respiratory diseases.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: December 27, 2011
    Assignee: Glaxo Group Limited
    Inventors: James Francis Callahan, Guoliang Lin, Zehong Wan, Hongxing Yan
  • Dual pharmacophores—PDE4-muscarinic antagonistics
    Patent number: 8071588
    Abstract: The present invention relates to novel compounds of Formula (I) and their use in the treatment of respiratory diseases, including anti-inflammatory and allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: December 6, 2011
    Assignee: Glaxo Group Limited
    Inventors: James Francis Callahan, Guoliang Lin, Zehong Wan, Hongxing Yan
  • Dual pharmacophores—PDE4-muscarinic antagonistics
    Patent number: 8067408
    Abstract: The present invention is directed to novel compounds of Formula (I), pharmaceutical compositions and their use in therapy, for example as inhibitors of phosphodiesterase type IV (PDE4) and as antagonists of muscarinic acetylcholine receptors (mAChRs), in the treatment of/and or prophylaxis of respiratory diseases, including antiinflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: November 29, 2011
    Assignee: Glaxo Group Limited
    Inventors: James Francis Callahan, Guoliang Lin, Zehong Wan, Hongxing Yan
  • M3 muscarinic acetylcholine receptor antagonists
    Patent number: 7906531
    Abstract: Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: March 15, 2011
    Assignee: Glaxo Group Limited
    Inventors: Zehong Wan, Hongxing Yan, Michael R. Palovich, Dramane I. Laine
  • NOVEL COMPOUNDS
    Publication number: 20100093766
    Abstract: Novel substituted 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(1H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.
    Type: Application
    Filed: November 16, 2009
    Publication date: April 15, 2010
    Inventors: James F. CALLAHAN, Zehong Wan, Hongxing Yan, Xichen Lin