Patents by Inventor Hongyi Wang
Hongyi Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240162453Abstract: Provided are a preparation method for and use of a self-assembly-based nitrogen-doped ordered porous precious metal nanomaterial. The preparation method includes: with a pyridine nitrogen-containing amphiphilic block copolymer as a structure-directing agent and a phenolic resin as a template agent, adding a precious metal precursor, inducing self-assembly by means of volatilization of a solvent, and carbonizing in an inert atmosphere to prepare the nitrogen-doped ordered porous precious metal nanomaterial. The regularity, dispersity and uniformity of the precious metal nanomaterial are achieved; the problems of migration and inactivation after agglomeration of precious metal nanoparticles are solved; the lifespan of precious metal particles is prolonged; and in addition, the ORR electro-catalytic property of the material can be improved, and the nitrogen-doped ordered porous precious metal nanomaterial can be used to prepare a cathodic oxygen reduction catalyst for a fuel cell.Type: ApplicationFiled: March 19, 2021Publication date: May 16, 2024Applicant: GUANGZHOU INSTITUTE OF ENERGY CONVERSION, CHINESE ACADEMY OF SCIENCESInventors: Zhida WANG, Changfeng YAN, Yi YANG, Zhuoxin LU, Yan SHI, Changqing GUO, Hongyi TAN, Lisha SHEN, Linxiu DENG
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Publication number: 20240157337Abstract: The invention discloses a composite photocatalyst of clay based bismuth phosphate homojunctions, preparation method and application thereof. The preparation method includes the following steps: S1, preparing a bismuth nitrate solution, sodium dihydrogen phosphate solution, and rectorite suspension; S2, adding bismuth nitrate solution into sodium dihydrogen phosphate solution, stirring thoroughly, then adding rectorite suspension for hydrothermal reaction, and finally separation, washing, and drying. This invention loads BiPO4 onto the rectorite while preparing BiPO4 through a one-step hydrothermal method. Due to the addition of rectorite, it can induce the BiPO4 heterophase homojunction structure composed of hexagonal phase and monazite monoclinic phase, improving the separation ability of electrons and holes.Type: ApplicationFiled: November 14, 2023Publication date: May 16, 2024Inventors: Junting Wang, Han Lin, Gaoke Zhang, Hongyi Yue, Yuan Li
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Publication number: 20240110131Abstract: A method for cleaning a water filtration membrane, the method having at least an alkaline cleaning step, wherein the method includes a first enzyme solution comprising a polypeptide having carbohydrase activity, and a second enzyme solution comprising a polypeptide having protease activity.Type: ApplicationFiled: February 9, 2022Publication date: April 4, 2024Inventors: Jian An HAO, Henrik Bangsoe NIELSEN, Agata ZAREBSKA, Gernot J. ABEL, Hongyi YANG, Yafang WANG, Jeffrey MELZER, Xingpeng ZHANG
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Publication number: 20230193223Abstract: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.Type: ApplicationFiled: September 16, 2022Publication date: June 22, 2023Inventors: Peter VANDER HORN, Cheng-Yao CHEN, Guobin LUO, Michael PREVITE, Jamshid TEMIROV, Theo NIKIFOROV, Zhaohui ZHOU, Hongye SUN, Yufang WANG, Stefanie Yukiko NISHIMURA, Hongyi WANG, Marian PERIS, Barnett ROSENBLUM, Michael PHELAN
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Patent number: 11447756Abstract: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.Type: GrantFiled: March 20, 2020Date of Patent: September 20, 2022Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Peter Vander Horn, Cheng-Yao Chen, Guobin Luo, Michael Previte, Jamshid Temirov, Theo Nikiforov, Zhaohui Zhou, Hongye Sun, Yufang Wang, Stefanie Yukiko Nishimura, Hongyi Wang, Marian Peris, Barnett Rosenblum, Michael Phelan
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Publication number: 20200231948Abstract: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.Type: ApplicationFiled: March 20, 2020Publication date: July 23, 2020Inventors: Peter VANDER HORN, Cheng-Yao CHEN, Guobin LUO, Michael PREVITE, Jamshid TEMIROV, Theo NIKIFOROV, Zhaohui ZHOU, Hongye SUN, Yufang WANG, Stefanie Yukiko NISHIMURA, Hongyi WANG, Marian PERIS, Barnett ROSENBLUM, Michael PHELAN
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Patent number: 10597642Abstract: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.Type: GrantFiled: August 30, 2017Date of Patent: March 24, 2020Assignee: Life Technologies CorporationInventors: Peter Vander Horn, Cheng-Yao Chen, Guobin Luo, Michael Previte, Jamshid Temirov, Theo Nikiforov, Zhaohui Zhou, Hongye Sun, Yufang Wang, Stefanie Yukiko Nishimura, Hongyi Wang, Marian Peris, Barnett Rosenblum, Michael Phelan
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Publication number: 20170369857Abstract: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.Type: ApplicationFiled: August 30, 2017Publication date: December 28, 2017Inventors: Peter VANDER HORN, Cheng-Yao CHEN, Guobin LUO, Michael PREVITE, Jamshid TEMIROV, Theo NIKIFOROV, Zhaohui ZHOU, Hongye SUN, Yufang WANG, Stefanie Yukiko NISHIMURA, Hongyi WANG, Marian PERIS, Barnett ROSENBLUM, Michael PHELAN
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Patent number: 9765310Abstract: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.Type: GrantFiled: January 8, 2016Date of Patent: September 19, 2017Assignee: Life Technologies CorporationInventors: Peter Vander Horn, Cheng-Yao Chen, Guobin Luo, Michael Previte, Jamshid Temirov, Theo Nikiforov, Zhaohui Zhou, Hongye Sun, Yufang Wang, Stefanie Yukiko Nishimura, Hongyi Wang, Marian Peris, Barnett Rosenblum, Michael Phelan
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Publication number: 20160208318Abstract: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.Type: ApplicationFiled: January 8, 2016Publication date: July 21, 2016Inventors: Peter Vander Horn, Cheng-Yao Chen, Guobin Luo, Michael Previte, Jamshid Temirov, Theo Nikiforov, Zhaohui Zhou, Hongye Sun, Yufang Wang, Stefanie Yukiko Nishimura, Hongyi Wang, Marian Peris, Barnett Rosenblum, Michael Phelan
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Patent number: 9255258Abstract: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.Type: GrantFiled: December 16, 2013Date of Patent: February 9, 2016Assignee: Life Technologies CorporationInventors: Peter Vander Horn, Cheng-Yao Chen, Guobin Luo, Michael Previte, Jamshid Temirov, Theo Nikiforov, Zhaohui Zhou, Hongye Sun, Yufang Wang, Stefanie Yukiko Nishimura, Hongyi Wang, Marian Peris, Barnett Rosenblum, Michael Phelan
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Publication number: 20140234853Abstract: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.Type: ApplicationFiled: December 16, 2013Publication date: August 21, 2014Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Peter VANDER HORN, Cheng-Yao CHEN, Guobin LUO, Michael PREVITE, Jamshid TEMIROV, Theo NIKIFOROV, Zhaohui ZHOU, Hongye SUN, Yufang WANG, Stefanie Yukiko NISHIMURA, Hongyi WANG, Marian PERIS, Barnett ROSENBLUM, Michael PHELAN
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Patent number: 8632975Abstract: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.Type: GrantFiled: May 28, 2010Date of Patent: January 21, 2014Assignee: Life Technologies CorporationInventors: Peter B. Vander Horn, Cheng-Yao Chen, Guobin Luo, Michael Previte, Jamshid Temirov, Theo Nikiforov, Zhaohui Zhou, Hongye Sun, Yufang Wang, Stefanie Yukiko Nishimura, Hongyi Wang, Marian Peris, Barnett B. Rosenblum, Michael Phelan
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Publication number: 20110165652Abstract: Compositions, systems and methods of sequencing are disclosed, where the compositions and systems include polymerase enzymes that have been genetically modified to more efficiently incorporate nucleotides including labels having a detectable properties that are released during incorporation, to augment a rate of labeled nucleotide incorporation, to augment a rate of pyrophosphate release, or to augment two or more of these properties and rates. Also disclosed are terminally labeled and dual labeled nucleotides, and click-chemistry based methods of synthesizing the same.Type: ApplicationFiled: January 14, 2009Publication date: July 7, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Susan H. Hardin, Tommie Lloyd Lincecum, JR., Norha Deluge, Hongyi Wang, Yuri Belosludtsev, Kristi Kincaid, Anelia Kraltcheva, Benjamin Stevens, Ming Fa, Amy Bryant, Amy Castillo, Hye Eun Kim, Uma Nagaswamy, Mitsu Sreedhar Reddy, Alok N. Bandekar, Ivan Pan, Andrei Volkov
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Publication number: 20100330570Abstract: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.Type: ApplicationFiled: May 28, 2010Publication date: December 30, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Peter B. VANDER HORN, Cheng-Yao Chen, Guobin Luo, Michael Previte, Jamshid Temirov, Theo Nikiforov, Zhaohui Zhou, Hongye Sun, Yufang Wang, Stefanie Yukiko Nishimura, Hongyi Wang, Marian Peris, Barnett B. Rosenblum, Michael Phelan
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Publication number: 20100323110Abstract: Support surfaces are disclosed that are designed to support molecules or molecular assemblies immobilized thereon so that the molecules or molecular assemblies can be observed in single molecule detections systems, where the support surfaces have reduced background and the fluorescent labels associated with the immobilized molecules or molecular assemblies have longer active lifetimes prior to permanent photo-bleaching or deactivation and have improve fluorescence properties and where the surfaces have more uniform fluorescent properties.Type: ApplicationFiled: August 6, 2010Publication date: December 23, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Yuri BELOSLUDTSEV, Nasanshargal BATTULGA, Mitsu REDDY, Anelia KRALTCHEVA, Susan H. HARDIN, Tommie L. LINCECUM, JR., Hongyi WANG, Norha DELUGE, Uma NAGASWAMY, Benjamin C. STEVENS, Kristi K. KINCAID
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Publication number: 20100317005Abstract: Labeled nucleotide triphosphates are disclosed having a label bonded to the gamma phosphate of the nucleotide triphosphate. Methods for using the gamma phosphate labeled nucleotide are also disclosed where the gamma phosphate labeled nucleotide are used to attach the labeled gamma phosphate in a catalyzed (enzyme or man-made catalyst) reaction to a target biomolecule or to exchange a phosphate on a target biomolecule with a labeled gamme phosphate. Preferred target biomolecules are DNAs, RNAs, DNA/RNAs, PNA, polypeptide (e.g., proteins enzymes, protein, assemblages, etc.), sugars and polysaccharides or mixed biomolecules having two or more of DNAs, RNAs, DNA/RNAs, polypeptide, sugars and polysaccharides moieties.Type: ApplicationFiled: March 15, 2010Publication date: December 16, 2010Applicants: LIFE TECHNOLOGIES CORPORATIONInventors: Susan H. Hardin, Hongyi Wang, Brent A. Mulder, Nathan K. Agnew, Tommie L. Lincecum, JR.
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Publication number: 20090186343Abstract: A novel and efficient single pot synthetic schemes are disclosed for preparing modified nucleotides, nucleotide analogs, nucleotide polyphosphates, and nucleotide polyphosphate analogs. The novel method is used to prepare nucleotides, nucleotide analogs, nucleotide polyphosphates, and nucleotide polyphosphate analogs having non-persistent or persistent and non-persistent modifications. Novel biomolecular reactions are also disclosed using the novel modified biomolecules disclosed herein.Type: ApplicationFiled: February 21, 2008Publication date: July 23, 2009Applicant: VISIGEN BIOTECHNOLOGIES, INC.Inventors: Hongyi Wang, Norha Deluge, Kristi Kincaid, Yuri Belosludtsev, Tommie Lincecum, JR., Amy Williams, Amy Bryant, Ming Fa, Benjamin Stevens, Susan H. Hardin
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Publication number: 20080091005Abstract: Modified nucleotides are disclosed for use in single molecule sequencing, methods for making the modified nucleotides and method for using the modified nucleotides. Linkers for making the modified nucleotide are also disclosed.Type: ApplicationFiled: July 20, 2007Publication date: April 17, 2008Applicants: VISIGEN BIOTECHNOLOGIES, INC., APPLIED BIOSYSTEMSInventors: Hongyi Wang, Xiaolian Gao, Peilin Yu, Mitsu Reddy, Susan Hardin, Tommie Lincecum, Amy Williams, Norha Deluge, Yuri Belosludtsev, Steven Menchen, Joe Lam, Jer-Kang Chen
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Publication number: 20080076189Abstract: Support surfaces are disclosed that are designed to support molecules or molecular assemblies immobilized thereon so that the molecules or molecular assemblies can be observed in single molecule detections systems, where the support surfaces have reduced background and the fluorescent labels associated with the immobilized molecules or molecular assemblies have longer active lifetimes prior to permanent photo-bleaching or deactivation and have improve fluorescence properties and where the surfaces have more uniform fluorescent properties.Type: ApplicationFiled: March 30, 2007Publication date: March 27, 2008Applicant: VISIGEN BIOTECHNOLOGIES, INC.Inventors: Yuri Belosludtsev, Nasanshargal Battulga, Mistu Reddy, Anelia Kraltcheva, Susan Hardin, Tommie Lincecum, Hongyi Wang, Norha Deluge, Uma Nagaswamy, Benjamin Stevens, Kristi Kincaid