Patents by Inventor Hooman Hafezi
Hooman Hafezi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11896792Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.Type: GrantFiled: December 20, 2019Date of Patent: February 13, 2024Assignee: One Drop Biosensor Technologies, LLCInventors: Ashwin Pushpala, Alan Szmodis, Matthew Chapman, Weldon Hall, Scott Miller, Hooman Hafezi
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Patent number: 11896793Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.Type: GrantFiled: November 4, 2021Date of Patent: February 13, 2024Assignee: One Drop Biosensor Technologies, LLCInventors: Ashwin Pushpala, Alan Szmodis, Matthew Chapman, Weldon Hall, Scott Miller, Hooman Hafezi
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Patent number: 11865289Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.Type: GrantFiled: November 2, 2021Date of Patent: January 9, 2024Assignee: One Drop Biosensor Technologies, LLCInventors: Ashwin Pushpala, Alan Szmodis, Matthew Chapman, Weldon Hall, Scott Miller, Hooman Hafezi
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Patent number: 11819650Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.Type: GrantFiled: December 17, 2020Date of Patent: November 21, 2023Assignee: One Drop Biosensor Technologies, LLCInventors: Ashwin Pushpala, Alan Szmodis, Matthew Chapman, Weldon Hall, Scott Miller, Hooman Hafezi
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Publication number: 20230216595Abstract: An apparatus that includes a partial power source including a first material and a second material, the partial power source configured to generate, upon contact with a conducting medium, a potential difference between the first material and the second material to provide power to a control device, and generate, using the first material and the second material, a current flow within the conducting medium, the current flow including information encoded based on a variable conductance between the first material and the second material.Type: ApplicationFiled: August 24, 2022Publication date: July 6, 2023Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Mark ZDEBLICK, Andrew THOMPSON, Aleksandr PIKELNY, Timothy L. ROBERTSON, Hooman HAFEZI
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Publication number: 20230157570Abstract: Power sources that enable in-body devices, such as implantable and ingestible devices, are provided. Aspects of the in-body power sources of the invention include a solid support, a first high surface area electrode and a second electrode. Embodiments of the in-power sources are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the power sources of the invention.Type: ApplicationFiled: August 25, 2022Publication date: May 25, 2023Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Hooman Hafezi, Timothy Robertson, Eric Snyder, Brad Cozad
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Publication number: 20230034761Abstract: A pharmaceutical product including a housing that defines a cavity, wherein the cavity stores a pharmaceutical material, and wherein the housing comprises a material configured to dissolve based on contact with a fluid, an ingestible device to encode information in a current signature, wherein the ingestible device is positioned within the housing, and a protective material that encompasses the ingestible device. The ingestible device may be attached to a flexible component, wherein the flexible component is configured to releasably secure the ingestible device within the housing.Type: ApplicationFiled: October 13, 2022Publication date: February 2, 2023Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Hooman HAFEZI, Raymond SCHMIDT
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Patent number: 11504511Abstract: A pharmaceutical product including a housing that defines a cavity, wherein the cavity stores a pharmaceutical material, and wherein the housing comprises a material configured to dissolve based on contact with a fluid, an ingestible device to encode information in a current signature, wherein the ingestible device is positioned within the housing, and a protective material that encompasses the ingestible device. The ingestible device may be attached to a flexible component, wherein the flexible component is configured to releasably secure the ingestible device within the housing.Type: GrantFiled: April 15, 2020Date of Patent: November 22, 2022Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Hooman Hafezi, Raymond Schmidt
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Publication number: 20220338796Abstract: The Breast Sense Feeding Monitor provides real-time measurement of breastfeeding metrics including milk volume and infant suck and swallow characteristics over multiple feedings. The wearable design lends itself to versions suitable for both home and in-clinic use.Type: ApplicationFiled: July 11, 2022Publication date: October 27, 2022Inventors: Hooman Hafezi, Mary Judith Insun Feezer, Douglas Alan Webb
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Patent number: 11476952Abstract: An apparatus that includes a partial power source including a first material and a second material, the partial power source configured to generate, upon contact with a conducting medium, a potential difference between the first material and the second material to provide power to a control device, and generate, using the first material and the second material, a current flow within the conducting medium, the current flow including information encoded based on a variable conductance between the first material and the second material.Type: GrantFiled: October 5, 2020Date of Patent: October 18, 2022Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Mark Zdeblick, Andrew Thompson, Aleksandr Pikelny, Timothy L. Robertson, Hooman Hafezi
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Publication number: 20220323364Abstract: Controlled activation identifiers for use in ingestible compositions, such as pharma-informatics enabled compositions, are provided. The identifiers include a controlled activation element that provides for activation of the identifier in response to the presence of a predetermined stimulus at a target site of interest. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.Type: ApplicationFiled: May 10, 2022Publication date: October 13, 2022Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Hooman Hafezi, Timothy Robertson, Olivier Colliou, Mark Zdeblick
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Patent number: 11464423Abstract: Power sources that enable in-body devices, such as implantable and ingestible devices, are provided. Aspects of the in-body power sources of the invention include a solid support, a first high surface area electrode and a second electrode. Embodiments of the in-power sources are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the power sources of the invention.Type: GrantFiled: January 22, 2015Date of Patent: October 11, 2022Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Hooman Hafezi, Timothy Robertson, Eric Snyder, Brad Cozad
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Publication number: 20220280061Abstract: The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.Type: ApplicationFiled: December 14, 2021Publication date: September 8, 2022Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Jeremy FRANK, Peter BJELETICH, Hooman HAFEZI, Robert AZEVEDO, Robert DUCK, Iliya PESIC, Benedict COSTELLO, Eric SNYDER
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Patent number: 11357730Abstract: Apparatuses for use with a pharmaceutically acceptable carrier. The apparatus can include a partial power source, which in turn includes electrodes or materials that are configured to generate an electrical potential upon contacting or being exposed to an ionic solution. The apparatus can further include a circuit electrically or communicatively coupled to the partial power source. The circuit can generate various types of signals, such as RF signals, when powered by the partial power source. The circuit is stably fittable to the pharmaceutically acceptable carrier. The apparatus can further include a barrier, a protective layer, or a membrane that isolates the electrodes or materials from the ionic solution and is configured to be dissolved by the ionic solution.Type: GrantFiled: December 28, 2018Date of Patent: June 14, 2022Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Hooman Hafezi, Timothy Robertson, Olivier Colliou, Mark Zdeblick
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Publication number: 20220116124Abstract: The present disclosure includes ingestible devices. In some examples, an ingestible device is presented that includes a framework, a control device secured to the framework, and a partial power source. The partial power source may include a first digestible material secured to the framework and electrically coupled to the control device, and a second digestible material electrically isolated from and dissimilar to the first digestible material, electrically coupled to the control device, and secured to the framework. The partial power source may be configured to provide power to the control device when the first and second digestible materials come in contact with a conductive fluid. The control device, after being provided power by the first and second digestible materials, may be configured to alter conductance between the first and second digestible materials to produce a current signature through the conductive fluid that is detectable by a receiver.Type: ApplicationFiled: May 20, 2021Publication date: April 14, 2022Applicant: OTSUKA PHARMACEUTICALInventors: Mark ZDEBLICK, Timothy ROBERTSON, Aleksandr PIKELNY, Hooman HAFEZI
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Publication number: 20220089823Abstract: Highly-swellable polymeric films are provided. Aspects also include ingestible compositions that include the highly-swellable polymeric film and an ingestible component. Aspects further include methods of making and using the compositions.Type: ApplicationFiled: September 27, 2021Publication date: March 24, 2022Inventors: Hooman Hafezi, Raymond Schmidt
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Publication number: 20220061693Abstract: Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more components that impart high reliability to the ingestible event marker. Further, the ingestible event markers may include an active agent. In some aspects, the active agent, such as a pharmaceutically active agent or a diagnostic agent may be associated with the membrane.Type: ApplicationFiled: September 10, 2021Publication date: March 3, 2022Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Hooman HAFEZI, Kit Yee AU-YEUNG, Robert DUCK, Maria HOLEN, Timothy ROBERTSON, Benedict COSTELLO
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Publication number: 20220054814Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.Type: ApplicationFiled: November 4, 2021Publication date: February 24, 2022Inventors: Ashwin Pushpala, Alan Szmodis, Matthew Chapman, Weldon Hall, Scott Miller, Hooman Hafezi
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Publication number: 20220054813Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.Type: ApplicationFiled: November 2, 2021Publication date: February 24, 2022Inventors: Ashwin Pushpala, Alan Szmodis, Matthew Chapman, Weldon Hall, Scott Miller, Hooman Hafezi
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Patent number: 11229378Abstract: The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.Type: GrantFiled: November 20, 2019Date of Patent: January 25, 2022Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Jeremy Frank, Peter Bjeletich, Hooman Hafezi, Robert Azevedo, Robert Duck, Iliya Pesic, Benedict Costello, Eric Snyder