Abstract: The present invention relates to a pharmaceutical composition comprising S(?)-cibenzoline or a pharmaceutically acceptable salt thereof as an active ingredient for treatment of hypertrophic cardiomyopathy, and a method for treatment of hypertrophic cardiomyopathy by using same.

Abstract: A pharmaceutical formulation including an immediate release layer and an extended release layer according to the present disclosure has a biphasic dissolution profile, such that it is possible to quickly reach an effective plasma concentration of cibenzoline at the early stage, and the effective plasma concentration may be continuously maintained at the late stage. Therefore, the medicinal effect of cibenzoline may be maintained only by an administration of a single formulation once a day.

Abstract: The present invention relates to a pharmaceutical composition comprising cibenzoline, especially, S(?)-cibenzoline or a pharmaceutically acceptable salt thereof as an active ingredient for treatment of hypertrophic cardiomyopathy, and a method for treatment of hypertrophic cardiomyopathy by using same. The treatment composition and method according to the present invention is used to treat a patient suffering from hypertrophic cardiomyopathy. In addition, the composition and method according to the present invention has excellent efficacy and safety, compared to conventional off-label standard of care (SOC).

Abstract: Provided is a portable terminal including a microphone hole formed to perforate from an outer wall of a housing to an inner wall of the housing, a duct groove extending from an inner side of the housing and being open on a top surface thereof, a microphone holder coupled with the top surface of the duct groove, and a microphone coupled with the microphone holder, in which a duct connected to the microphone hole is formed by coupling the microphone holder with the duct groove, and the microphone is connected with the microphone hole through the duct. The duck is formed by coupling the duct groove formed in the housing of the terminal with the microphone holder coupled with the microphone, thereby smoothly delivering input sound such as user's voice to the microphone and contributing to the slimness of the terminal.

Abstract: Provided is a portable terminal including a microphone hole formed to perforate from an outer wall of a housing to an inner wall of the housing, a duct groove extending from an inner side of the housing and being open on a top surface thereof, a microphone holder coupled with the top surface of the duct groove, and a microphone coupled with the microphone holder, in which a duct connected to the microphone hole is formed by coupling the microphone holder with the duct groove, and the microphone is connected with the microphone hole through the duct. The duck is formed by coupling the duct groove formed in the housing of the terminal with the microphone holder coupled with the microphone, thereby smoothly delivering input sound such as user's voice to the microphone and contributing to the slimness of the terminal.