Patents by Inventor Houle Wang
Houle Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240120847Abstract: A voltage regulator having a multiple of main stages and at least one accelerated voltage regulator (AVR) bridge is provided. The main stages may respond to low frequency current transients and provide DC output voltage regulation. The AVR bridges are switched much faster than the main stages and respond to high frequency current transients without regulating the DC output voltage. The AVR bridge frequency response range can overlap with the main stage frequency response range, and the lowest frequency to which the AVR bridges respond may be set lower than the highest frequency to which the main stages respond.Type: ApplicationFiled: October 6, 2022Publication date: April 11, 2024Inventors: Shuai Jiang, Xin Li, Woon-Seong Kwon, Cheng Chung Yang, Qiong Wang, Nam Hoon Kim, Mikhail Popovich, Houle Gan, Chenhao Nan
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Publication number: 20140145075Abstract: An API (Atmospheric Pressure Interface) ion source and a mass spectrometer with the same are disclosed. In the disclosed API ion source and the mass spectrometer with the same, the included angle ? between the capillary (2) and the mass analyzer (4) of the mass spectrometer (10) is 80°˜150°. The repeller electrode (3) is installed outside the included angle a and a 110˜380V DC voltage is applied thereto, so that the sample ions with low kinetic energy in the sample ion flow passed through the capillary (2) change the flying direction thereof by an angle with 180°-? and subsequently enter the mass analyzer (4).Type: ApplicationFiled: July 29, 2011Publication date: May 29, 2014Applicant: BEIJING PURKINJE GENERAL INSTRUMENT CO., LTD.Inventors: Xiaohua Zhang, Houle Wang, Hua Zhang, Yingjian Shang, Yongguang Du
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Patent number: 7315020Abstract: The ionization chamber consists of a plurality of ports to accept multiple identical devices or varying devices. Ports may be arranged at various positions on the ionization chamber and at various angles with respect to the sampling orifice leading into the vacuum chamber of the mass spectrometer. A plurality of sprayers may operate in a time modulated manner and thereby the simultaneous multiplexed analysis of a multitude of samples is facilitated.Type: GrantFiled: June 24, 2002Date of Patent: January 1, 2008Assignee: Bruker Daltonics, Inc.Inventors: Melvin A. Park, Houle Wang, Frank Laukien
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Patent number: 7126115Abstract: The present invention provides a nanospray means and method for use in mass analysis instruments. Specifically, a nanospray assembly is composed in part of a base, union, retainer, and nanospray needle, and an entrance cap, first capillary section, and union. Adjustments to the position of the nanospray needle within this assembly are made independent of the remainder of the ion source. The nanospray assembly is integrated with the remainder of the source by joining the first capillary section (of the nanospray assembly) with a second capillary section which is fixed in the body of the source.Type: GrantFiled: June 14, 2004Date of Patent: October 24, 2006Assignee: Bruker Daltonics, Inc.Inventors: Melvin A. Park, Houle Wang
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Publication number: 20050109948Abstract: The present invention provides a nanospray means and method for use in mass analysis instruments. Specifically, a nanospray assembly is composed in part of a base, union, retainer, and nanospray needle, and an entrance cap, first capillary section, and union. Adjustments to the position of the nanospray needle within this assembly are made independent of the remainder of the ion source. The nanospray assembly is integrated with the remainder of the source by joining the first capillary section (of the nanospray assembly) with a second capillary section which is fixed in the body of the source.Type: ApplicationFiled: June 14, 2004Publication date: May 26, 2005Inventors: Melvin Park, Houle Wang
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Patent number: 6809312Abstract: The present invention is for an improved ionization source chamber and ion beam delivery system which includes a vacuum chamber and flange arrangement, for mounting the means for transferring sample ions from the port to a mass analyzer and for mounting the ion production means, respectively. The flange containing the ion production means may be attached to the vacuum chamber via a hinge such that the flange can open as a door to provide easy access to the ion transfer electrodes in the vacuum chamber. Further, a variety of different ion production means may be mounted on the flange of the ionization source chamber of the present invention. As a result, any ion production means may be used with the present invention by substituting a flange which includes the desired ion production means.Type: GrantFiled: May 12, 2000Date of Patent: October 26, 2004Assignee: Bruker Daltonics, Inc.Inventors: Melvin A. Park, Houle Wang
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Patent number: 6797948Abstract: Disclosed is an ion guide for transferring ions from and ion source through vacuum regions in a mass spectrometer. The ion guide includes a housing with insulating holders provided to secure electrode rods of multiple devices in longitudinal alignment for the transmission of ions from the ion source to a mass analyzer. The device comprise a plurality of electrode rods each having at least one connecting leg. The rods are connected to the insulating holders via these connecting legs using connecting plates mounted on either side of and adjacent to each insulating border such that the connecting plates are in electrical contact with connecting legs. The connecting plates also have positioning groves to hold the connecting legs in position such that electrical contact is maintained between groups of the electrode rods.Type: GrantFiled: August 10, 2000Date of Patent: September 28, 2004Assignee: Bruker Daltonics, Inc.Inventor: Houle Wang
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Patent number: 6770871Abstract: A tandem mass spectrometer is provided including two mass analyzers with an ion fragmentation device interposed between the two mass analyzers. The first mass analyzer is a non-destructive mass analyzer, such as an ion trap, to initially collect and hold parent ions and sequentially release parent ions of known mass to charge ratio. The released parent ions pass through the fragmentation device, such as a collision cell, where the parent ions are fragmented into daughter ions. These daughter ions then pass on to the second mass analyzer. The second mass analyzer is of a high speed full spectrum type, such as a time of flight analyzer, so that a full spectrum of mass data is provided for the daughter ions, to go with parent ion mass spectrum data from the first mass analyzer.Type: GrantFiled: May 31, 2002Date of Patent: August 3, 2004Assignee: Michrom BioResources, Inc.Inventors: Houle Wang, Kerry D. Nugent
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Patent number: 6753521Abstract: The present invention provides a nanospray means and method for use in mass analysis instruments. Specifically, a nanospray assembly is composed in part of a base, union, retainer, and nanospray needle, and an entrance cap, first capillary section, and union. Adjustments to the position of the nanospray needle within this assembly are made independent of the remainder of the ion source. The nanospray assembly is integrated with the remainder of the source by joining the first capillary section (of the nanospray assembly) with a second capillary section which is fixed in the body of the source.Type: GrantFiled: February 18, 2000Date of Patent: June 22, 2004Assignee: Bruker Daltonics, Inc.Inventors: Melvin A. Park, Houle Wang
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Publication number: 20030071209Abstract: The ionization chamber consists of a plurality of ports to accept multiple identical devices or varying devices. Ports may be arranged at various positions on the ionization chamber and at various angles with respect to the sampling orifice leading into the vacuum chamber of the mass spectrometer. A plurality of sprayers may operate in a time modulated manner and thereby the simultaneous multiplexed analysis of a multitude of samples is facilitated.Type: ApplicationFiled: June 24, 2002Publication date: April 17, 2003Inventors: Melvin A. Park, Houle Wang, Frank Laukien
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Patent number: 6410914Abstract: The ionization chamber consists of a plurality of ports to accept multiple identical devices or varying devices. Ports may be arranged at various positions on the ionization chamber and at various angles with respect to the sampling orifice leading into the vacuum chamber of the mass spectrometer. A plurality of sprayers may operate in a time modulated manner and thereby the simultaneous multiplexed analysis of a multitude of samples is facilitated.Type: GrantFiled: March 5, 1999Date of Patent: June 25, 2002Assignee: Bruker Daltonics Inc.Inventors: Melvin A. Park, Houle Wang, Frank Laukien
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Patent number: 6107626Abstract: A device and method for forming ions by inductive ionization is disclosed. The device is an ion source that includes a capacitor having a pair of electrodes separated by a dielectric material. The method of the invention uses the capacitor-based ion source to form positive and negative ions including multiply-charged ions.Type: GrantFiled: February 9, 1999Date of Patent: August 22, 2000Assignee: The University of WashingtonInventors: Houle Wang, Murray Hackett
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Patent number: 5869832Abstract: A device and method for forming ions by inductive ionization is disclosed. The device is an ion source that includes a capacitor having a pair of electrodes separated by a dielectric material. The method of the invention uses the capacitor-based ion source to form positive and negative ions including multiply-charged ions.Type: GrantFiled: October 14, 1997Date of Patent: February 9, 1999Assignee: University of WashingtonInventors: Houle Wang, Murray Hackett