Patents by Inventor Howard B. Cottam

Howard B. Cottam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS WITH GLUCOCORTICOID SPARING EFFECTS AND USES THEREOF
    Publication number: 20230365570
    Abstract: The disclosure relates to 1H-pyrazolo[3,4-d]pyrimidin-4-amine compounds and 1-nitro-5-amido-disubstituted furan compounds, or a pharmaceutically acceptable salt thereof, and methods for their use in treating, among other conditions, inflammatory diseases or an autoimmune diseases.
    Type: Application
    Filed: October 5, 2021
    Publication date: November 16, 2023
    Inventors: Dennis A. Carson, Tomoko Hayashi, Mary Patricia Corr, Howard B. cottam, Tadashi Hosoya, Nikunj Shukla
  • N-ARYL SULFONAMIDE DERIVATIVES AS VACCINE ADJUVANT
    Publication number: 20220305121
    Abstract: Bis-aryl sulfonamide compounds and methods of using those compounds, e.g., in a method of enhancing or prolonging an immune response, are provided. For example, the compounds may be employed with a vaccine and optionally at least one other adjuvant and/or one or more TLR ligands, at least one MAP kinase inhibitor, or any combination thereof.
    Type: Application
    Filed: August 15, 2020
    Publication date: September 29, 2022
    Inventors: Dennis A. Carson, Tomoko Hayashi, Maripat Corr, Howard B. Cottam, Nijunj Shukla, Michael Chan
  • TLR4-TLR7 LIGAND FORMULATIONS AS VACCINE ADJUVANTS
    Publication number: 20220152188
    Abstract: A method to enhance an immune response in a mammal, and a composition comprising liposomes, a TLR4 agonist and a TLR7 agonist, are provided.
    Type: Application
    Filed: March 13, 2020
    Publication date: May 19, 2022
    Inventors: Dennis A. Carson, Howard B. Cottam, Tomoko Hayashi, Mary Patricia Corr
  • VACCINE ADJUVANT
    Publication number: 20210380546
    Abstract: Compounds useful as an adjuvant, e.g., formulas (I)-(VI) and uses thereof, for example, with immunogenic moieties or other adjuvants, are provided.
    Type: Application
    Filed: October 22, 2019
    Publication date: December 9, 2021
    Inventors: Dennis Carson, Mary Patricia Corr, Howard B. Cottam, Tomoko Hayashi, Nikunj Shukla
  • Compositions and methods for modulating TLR4
    Patent number: 9505768
    Abstract: Provided herein, inter alia, are methods and compositions for modulating TLR-4.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: November 29, 2016
    Assignee: The Regents Of The University Of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Tomoko Hayashi, Michael Chan, Mary P. Corr
  • USES OF PHOSPHOLIPID CONJUGATES OF SYNTHETIC TLR7 AGONISTS
    Publication number: 20160199499
    Abstract: The invention provides uses for phospholipid conjugates of TLR agonists as enhancers of an innate immune response. Specifically, purine derivatives which are conjugated to a phospholipid or an analog thereof are disclosed as having activity as TLR7 agonists, capable of inducing an innate immune response upon administration in an effective amount to a subject. The phospholipid moiety of the TLR7 agonist contains one or more alkyl ether or ester moieties.
    Type: Application
    Filed: August 14, 2014
    Publication date: July 14, 2016
    Inventors: Dennis A. Carson, Tomoko Hayashi, Howard B. Cottam
  • SYNTHETIC TLR4 AND TLR7 LIGANDS AS VACCINE ADJUVANTS
    Publication number: 20150366962
    Abstract: This disclosure relates to compositions and methods useful to augment an immune response and methods and compositions for inducing immunogenicity to influenza antigens.
    Type: Application
    Filed: June 20, 2015
    Publication date: December 24, 2015
    Inventors: Dennis A. Carson, Howard B. Cottam, Tomoko Hayashi, Maripat Corr, Peter Palese, Peter Goff
  • COMPOSITIONS AND METHODS FOR MODULATING TLR4
    Publication number: 20150197527
    Abstract: Provided herein, inter alia, are methods and compositions for modulating TLR-4.
    Type: Application
    Filed: March 27, 2015
    Publication date: July 16, 2015
    Inventors: Dennis A. Carson, Howard B. Cottam, Tomoko Hayashi, Michael Chan, Mary P. Corr
  • Conjugates of synthetic TLR agonists and uses therefor
    Patent number: 9050376
    Abstract: The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: June 9, 2015
    Assignee: The Regents of the University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Wolfgang Wrasidlo, Christina C. N. Wu, Gregory A. Daniels
  • NOVEL IMMUNE ACTIVATORS: SUBSTITUTE 4-AMINOQUINAZOLINES
    Publication number: 20150132342
    Abstract: Provided herein are compounds and methods for modulating an immune response in a subject in need thereof. Further provided herein are compounds and methods for modulating a toll-like receptor protein.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 14, 2015
    Inventors: Dennis A. Carson, Howard B. Cottam, Tomoko Hayashi, Afshin Nour
  • CONJUGATES OF SYNTHETIC TLR AGONISTS AND USES THEREFOR
    Publication number: 20140302120
    Abstract: The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma.
    Type: Application
    Filed: June 19, 2014
    Publication date: October 9, 2014
    Inventors: Dennis A. Carson, Howard B. Cottam, Wolfgang Wrasidlo, Christina C.N. Wu, Gregory A. Daniels
  • Purine analogs
    Patent number: 8846697
    Abstract: The present invention provides purine analog compounds, as well as compositions and methods of using them, for example, to prevent or treat various diseases and disorders in human and non-human animals.
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: September 30, 2014
    Assignee: The Regents of the University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Guangyi Jin, Christina C. N. Wu, Suzanne Grimshaw
  • Conjugates of synthetic TLR agonists and uses therefor
    Patent number: 8790655
    Abstract: The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: July 29, 2014
    Assignee: The Regents of The University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Wolfgang Wrasidlo, Christina C. N. Wu, Gregory A. Daniels
  • Toll-like receptor modulators and treatment of diseases
    Patent number: 8729088
    Abstract: Provided herein are small molecule conjugates that are agonists or antagonists of one or more toll-like receptors.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: May 20, 2014
    Assignee: The Regents of the University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Tomoko Hayashi, Michael Chan
  • USES OF PHOSPHOLIPID CONJUGATES OF SYNTHETIC TLR7 AGONISTS
    Publication number: 20130202629
    Abstract: The invention provides uses for phospholipid conjugates of TLR agonists, for instance in vaccines, and to prevent, inhibit or treat a variety of disorders including inflammation, cancer and pathogen, e.g., microbe, infection.
    Type: Application
    Filed: April 29, 2011
    Publication date: August 8, 2013
    Applicant: The Regents of the University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Tomoko Hayashi, Michael Chan, Christina C.N. Wu
  • TLR AGONISTS
    Publication number: 20130165455
    Abstract: The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal, preferably a human and can help direct the pharmacophore to the receptor within the endosomes of target cells and enhance the signal transduction induced by the pharmacophore.
    Type: Application
    Filed: November 20, 2012
    Publication date: June 27, 2013
    Applicant: The Regents of The University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Michael Chan, Christina C.N. Wu, Suzanne Grimshaw
  • CONJUGATES OF SYNTHETIC TLR AGONISTS AND USES THEREFOR
    Publication number: 20120148660
    Abstract: The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma.
    Type: Application
    Filed: February 7, 2008
    Publication date: June 14, 2012
    Applicant: Regents of the University of California, San Diego UCSD Technology Transfer Office
    Inventors: Dennis A. Carson, Howard B. Cottam, Wolfgang Wrasidlo, Christina C.N. Wu, Gregory A. Daniels
  • Derivatives of hypoestoxide and related compounds
    Patent number: 8124654
    Abstract: Novel diterpene compounds, in particular, hypoestoxide-related compounds, are provided in pure form or as contained in the native plant source, for treatment and prophylaxis of cancer, inflammatory diseases, hyperlipidemias, malaria, and diabetes mellitus. Embodiments also pertain to methods for using the hypoestoxide-related compounds to treat various diseases and symptoms associated with those diseases.
    Type: Grant
    Filed: November 11, 2008
    Date of Patent: February 28, 2012
    Assignee: Immune Modulation, Inc.
    Inventors: Howard B. Cottam, Emmanuel A. Ojo-Amaize, Emeka J. Nchekwube, Olusola A. Oyemade, Donna G. Nchekwube
  • AMIDE DERIVATIVES OF ETHACRYNIC ACID
    Publication number: 20110306671
    Abstract: The invention provides ethacrynic acid derivatives useful to prevent, inhibit or treat a variety of disorders or diseases including cancer and inflammatory disorders.
    Type: Application
    Filed: December 16, 2009
    Publication date: December 15, 2011
    Applicant: The Regents of the The University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Guangyi Jin, Desheng Lu
  • PURINE ANALOGS
    Publication number: 20110098294
    Abstract: The present invention provides a new patentable class of purine analog compounds, as well as compositions and methods of using them, for example, to prevent or treat various diseases and disorders in human and non-human animals.
    Type: Application
    Filed: April 23, 2007
    Publication date: April 28, 2011
    Inventors: Dennis A. Carson, Howard B. Cottam, Guangyi Jin, Christina C.N. Wu, Kenji Takabayashi, Suzanne Grimshaw