Patents by Inventor Howard D. Stang

Howard D. Stang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene transfer in intact mammals
    Patent number: 4497796
    Abstract: Methods and compositions are provided for gene transfer to intact mammals with expression of the exogenous genetic material in the host. Mammalian host cells which are regenerative, normally highly proliferative or subject to induced proliferation, are transformed or modified in vitro with DNA capable of replication and expression in the host cell, wherein the DNA becomes incorporated into the cell. The modified cells are found to regenerate in the host with expression of the introduced DNA. Particularly, mammalian cells were modified with genes providing for overproduction of a particular enzyme. The modified cells were reintroduced in the host under conditions providing for selective advantage of the modified cells.
    Type: Grant
    Filed: December 8, 1982
    Date of Patent: February 5, 1985
    Assignee: The Regents of the University of California
    Inventors: Winston A. Salser, Martin J. Cline, Howard D. Stang
  • Gene transfer in intact mammals
    Patent number: 4396601
    Abstract: Methods and compositions are provided for gene transfer to intact mammals with expression of the exogenous genetic material in the host. Mammalian host cells which are regenerative, normally highly proliferative or subject to induced proliferation, are transformed or modified in vitro with DNA capable of replication and expression in the host cell, wherein the DNA becomes incorporated into the cell. The modified cells are found to regenerate in the host with expression of the introduced DNA. Particularly, mammalian cells were modified with genes providing for overproduction of a particular enzyme. The modified cells were reintroduced in the host under conditions providing for selective advantage of the modified cells.
    Type: Grant
    Filed: March 26, 1980
    Date of Patent: August 2, 1983
    Assignee: The Regents of the University of Calif.
    Inventors: Winston A. Salser, Martin J. Cline, Howard D. Stang