Abstract: Methods and systems are provided for ionizing molecules for the purpose of analysis by mass spectrometry, in which gaseous material from a sample substrate is generated using laser desorption. The laser is provided having a pulse range of about 1-1000 picoseconds to produce the gaseous material. The gaseous material is heated to generate ions from the molecules present in the gaseous material where the amount of heat that is applied is in the temperature range of 45° C. to 250° C. and the applied heat results in soft ionization of the molecules. The ionized molecules are transported to a mass spectrometer for analysis.

Abstract: Methods and systems are provided for ionizing molecules for the purpose of analysis by mass spectrometry, in which gaseous material from a sample substrate is generated using laser desorption. The laser is provided having a pulse range of about 1-1000 picoseconds to produce the gaseous material. The gaseous material is heated to generate ions from the molecules present in the gaseous material where the amount of heat that is applied is in the temperature range of 45° C. to 250° C. and the applied heat results in soft ionization of the molecules. The ionized molecules are transported to a mass spectrometer for analysis.

Abstract: A fixation device is provided to immobilize a spinal motion segment and promote posterior fusion, used as stand-alone instrumentation or as an adjunct to an anterior approach. The device functions as a multi-level fusion system including modular single-level implementations. At a single-level the implant includes a pair of plates spanning two adjacent vertebrae with embedding teeth on the medially oriented surfaces directed into the spinous processes or laminae. The complementary plates at a single-level are connected via a cross-post passed through the interspinous process gap The freedom of rotational motion of both the cross-post and collar enables the complementary plates to be connected at a range of angles in the axial and coronal planes accommodating varying morphologies of the posterior elements in the cervical, thoracic and lumbar spine. To achieve multi-level fusion the single-level implementation can be connected in series using an interlocking mechanism fixed by a set-screw.

Abstract: A fixation device to immobilize a spinal motion segment and promote posterior fusion, used as stand-alone instrumentation or as an adjunct to an anterior approach. The device functions as a multi-level fusion system including modular single-level implementations. At a single-level the implant includes a pair of plates spanning two adjacent vertebrae with embedding teeth on the medially oriented surfaces directed into the spinous processes or laminae. The complementary plates at a single-level are connected via a cross-post with a hemi-spherical base and cylindrical shaft passed through the interspinous process gap and ratcheted into an expandable collar. The expandable collar's spherical profile contained within the opposing plate allows for the ratcheting mechanism to be correctly engaged creating a uni-directional lock securing the implant to the spine when a medially directed force is applied to both complementary plates using a specially designed compression tool.