Patents by Inventor Howard L. Weiner

Howard L. Weiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of autoimmune arthritis by oral administration of type I or type III collagen
    Patent number: 5733547
    Abstract: The invention is directed to a method of treating a T cell-mediated autoimmune disease in animals, including humans, by the oral administration of autoantigens, fragments of autoantigens, or analogs structurally related to those autoantigens, which are specific for the particular autoimmune disease. The method of the invention includes both prophylactic and therapeutic measures.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: March 31, 1998
    Assignee: AutoImmune, Inc.
    Inventors: Howard L. Weiner, David A. Hafler
  • Method of treating rheumatoid arthritis with soluble collagen
    Patent number: 5720955
    Abstract: The present invention is directed to a method and pharmaceutical formulations for the treatment of autoimmune arthritis and animal models therefore in mammals, including humans, by the oral, enteral or by-inhalation administration of whole collagen protein or biologically active peptide fragments of collagen.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 24, 1998
    Assignee: AutoImmune, Inc.
    Inventors: Howard L. Weiner, David E. Trentham, David A. Hafler
  • Method and compositions for suppressing allograft rejection in mammals
    Patent number: 5681556
    Abstract: Disclosed herein are methods for suppressing allograft rejection in mammals comprising administering to a mammal about to undergo or having undergone allograft surgery an agent selected from the group consisting of splenic tissue from an allograft donor, splenic extracts, cultured lymphocytes from an allograft donor, extracts of said cultured lymphocytes, MHC antigens, transplantation rejection suppressive fragments and analogs of MHC antigens in an oral or aerosol form. Also disclosed herein are pharmaceutical formulations and dosage forms for use in said methods.
    Type: Grant
    Filed: November 29, 1993
    Date of Patent: October 28, 1997
    Assignee: Autoimmune Inc.
    Inventors: Howard L. Weiner, David Allen Hafler, Charles B. Carpenter, Mohamed Sayegh, Zhengyi Zhang
  • Treatment of autoimmune diseases by aerosol administration of autoantigens
    Patent number: 5645820
    Abstract: Disclosed herein is a method for treating autoimmune diseases in mammals by administration of one or more agents selected from the group consisting of autoantigens specific for the autoimmune disease, disease-suppressive fragments and analogs of said autoantigen in aerosol form.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: July 8, 1997
    Assignee: AutoImmune, Inc.
    Inventors: David Allen Hafler, Howard L. Weiner
  • Method of treating or preventing type 1 diabetes by oral administration of insulin
    Patent number: 5643868
    Abstract: Disclosed herein are methods for treating or preventing a disease in mammals having the characteristics of Type 1 diabetes comprising administering insulin or disease suppressive fragments of insulin or analogs thereof in oral or aerosol dosage forms to said mammals. Also disclosed herein are pharmaceutical formulation or dosage forms for use in the methods.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 1, 1997
    Assignee: Autoimmune, Inc.
    Inventors: Howard L. Weiner, George Eisenbarth, David Allen Hafler, Zhengyi Zhang
  • Treatment of autoimmune diseases by aerosol administration of autoantigens
    Patent number: 5641473
    Abstract: Disclosed herein is a method for treating autoimmune diseases in mammals by administration of one or more agents selected from the group consisting of autoantigens specific for the autoimmune disease, disease-suppressive fragments and analogs of said autoantigen in aerosol form.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 24, 1997
    Assignee: AutoImmune, Inc.
    Inventors: David Allen Hafler, Howard L. Weiner
  • Prevention of autoimmune diseases by aerosol administration of autoantigens
    Patent number: 5641474
    Abstract: Disclosed herein is a method for treating autoimmune diseases in mammals by administration of one or more agents selected from the group consisting of autoantigens specific for the autoimmune disease, disease-suppressive fragments and analogs of said autoantigen in aerosol form.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 24, 1997
    Assignee: AutoImmune, Inc.
    Inventors: David Allen Hafler, Howard L. Weiner
  • Suppression of proliferative response and induction of tolerance with polymorphic class II MHC allopeptides
    Patent number: 5593698
    Abstract: Described are methods for: (a) suppressing the ability of T-cells from a mammal to proliferate in response to stimulation by nonself mammalian tissue; and (b) suppressing immune response which leads to allograft rejection in a mammal receiving an allograft from a donor mammal. The methods involve orally administering to the mammal to be thus treated a composition comprising at least one of: (i) a major histocompatibility complex Class II antigen from a second nonself mammal or from tissue of a mammal syngeneic to said nonself mammal; (ii) at least one synthetic peptide corresponding to a T-cell suppressive fragment of said Class II antigen, said composition being administered in an amount effective to suppress said proliferation. The foregoing compositions are also described.
    Type: Grant
    Filed: March 5, 1993
    Date of Patent: January 14, 1997
    Assignee: Autoimmune, Inc.
    Inventors: Howard L. Weiner, David A. Hafler, Charles B. Carpenter, Mohamed Sayegh, Zhengyi Zhang
  • Treatment of autoimmune diseases through administration by inhalation of autoantigens
    Patent number: 5571500
    Abstract: Disclosed herein is a method for treating autoimmune diseases in mammals by administration of one or more agents selected from the group consisting of autoantigens specific for the autoimmune disease, disease-suppressive fragments and analogs of said autoantigen in aerosol form.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 5, 1996
    Assignee: Autoimmune, Inc.
    Inventors: David A. Hafler, Howard L. Weiner
  • Treatment of autoimmune diseases by aerosol administration of autoantigens
    Patent number: 5571499
    Abstract: Disclosed herein is a method for treating autoimmune diseases in mammals by administration of one or more agents selected from the group consisting of autoantigens specific for the autoimmune disease, disease-suppressive fragments and analogs of said autoantigen in aerosol form.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 5, 1996
    Assignee: Autoimmune, Inc.
    Inventors: David A. Hafler, Howard L. Weiner
  • Method of treating rheumatoid arthritis with type II collagen
    Patent number: 5399347
    Abstract: The present invention is directed to a method and pharmaceutical formulations for the treatment of autoimmune arthritis and animal models therefore in mammals, including humans, by the oral, enteral or by-inhalation administration of whole collagen protein or biologically active peptide fragments of collagen.
    Type: Grant
    Filed: September 25, 1992
    Date of Patent: March 21, 1995
    Assignee: Autoimmune, Inc.
    Inventors: David E. Trentham, Howard L. Weiner, David A. Hafler