Patents by Inventor Hsin-I Peng

Hsin-I Peng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA microarray having hairpin probes tethered to nanostructured metal surface
    Patent number: 8957002
    Abstract: A sensor chip and detection device are disclosed. The sensor chip includes a substrate, at least a portion of which is covered by a metal nanoparticle film; a first nucleic acid molecule that is characterized by being able to (i) self-anneal into a hairpin conformation and (ii) hybridize specifically to a target nucleic acid molecule, the first nucleic acid molecule having first and second ends, which first end is tethered to the metal nanoparticle film; and a first fluorophore bound to the second end of the first nucleic molecule. When the first nucleic acid molecule is in the hairpin conformation, the metal nanoparticle film substantially quenches fluorescent emissions by the first fluorophore, and when the first nucleic acid molecule is in a non-hairpin conformation fluorescent emissions by the first fluorophore are surface plasmon-enhanced.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: February 17, 2015
    Assignee: University of Rochester
    Inventors: Benjamin L. Miller, Todd D. Krauss, Lewis J. Rothberg, Hsin-I Peng
  • DNA MICROARRAY HAVING HAIRPIN PROBES TETHERED TO NANOSTRUCTURED METAL SURFACE
    Publication number: 20090137418
    Abstract: A sensor chip and detection device are disclosed. The sensor chip includes a substrate, at least a portion of which is covered by a metal nanoparticle film; a first nucleic acid molecule that is characterized by being able to (i) self-anneal into a hairpin conformation and (ii) hybridize specifically to a target nucleic acid molecule, the first nucleic acid molecule having first and second ends, which first end is tethered to the metal nanoparticle film; and a first fluorophore bound to the second end of the first nucleic molecule. When the first nucleic acid molecule is in the hairpin conformation, the metal nanoparticle film substantially quenches fluorescent emissions by the first fluorophore, and when the first nucleic acid molecule is in a non-hairpin conformation fluorescent emissions by the first fluorophore are surface plasmon-enhanced.
    Type: Application
    Filed: November 5, 2008
    Publication date: May 28, 2009
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Benjamin L. Miller, Todd D. Krauss, Lewis J. Rothberg, Hsin-I Peng
  • Growth factor encapsulation system for enhancing bone formation
    Publication number: 20060159663
    Abstract: This invention provides articles of manufacture, compositions of matter and methods related to a growth factor encapsulation system for enhancing bone formation.
    Type: Application
    Filed: July 29, 2005
    Publication date: July 20, 2006
    Inventors: Helen Lu, Regina Landesberg, Jennifer Vo, Rick Tsay, Hsin-I Peng