Patents by Inventor Hsuan-Shu Lee

Hsuan-Shu Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KIT FOR DRUG METABOLISM DETERMINATION AND TOXICITY PREDICTION
    Publication number: 20140106356
    Abstract: The present invention provides a kit comprising a cell transfected with hepatic transcription regulators, and a culture medium that support growth of the cell. The present invention further provides a method for determining drug metabolism and predicting drug toxicity, comprising transfecting a cell with hepatic transcription regulators, and culturing the cell on a medium.
    Type: Application
    Filed: October 12, 2012
    Publication date: April 17, 2014
    Applicant: NATIONAL TAIWAN UNIVERSITY
    Inventors: Hsuan-Shu Lee, Guan-Tarn Huang, Kai-Chiang Yang, Tsai-Shin Chiang, Feng-Huei Lin
  • Hepatocyte precursor cell lines
    Patent number: 8404481
    Abstract: The present invention is directed to methods for readily generating hepatocyte precursor cell lines that retain hepatocyte-specific functions after extensive in vitro culturing. The methods comprise isolating and culturing hepatocyte precursor cell lines under permissive culture conditions that suppress asymmetric cell kinetics and allow exponential growth of the precursor cells, followed by transferring the hepatocyte precursor cell lines to non-permissive culture conditions that allow expression of asymmetric cell kinetics and induce expression of hepatocyte-specific characteristics.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: March 26, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: James L. Sherley, Hsuan-Shu Lee, Gracy G. Crane
  • INTRAVITAL SAMPLE DEVICE FOR IN VIVO DRUG SCREENING
    Publication number: 20120035444
    Abstract: The present invention provides sample devices. The present invention also provides in vivo drug screening systems. The present invention further provides a method for in vivo drug screening.
    Type: Application
    Filed: June 29, 2011
    Publication date: February 9, 2012
    Applicant: NATIONAL TAIWAN UNIVERSITY
    Inventors: CHEN-YUAN DONG, HSUAN-SHU LEE, FENG-CHIEH LI, TZU-LIN SUN, YUAN LIU, PO-SHOU CHANG
  • HEPATOCYTE PRECURSOR CELL LINES
    Publication number: 20100086936
    Abstract: The present invention is directed to methods for readily generating hepatocyte precursor cell lines that retain hepatocyte-specific functions after extensive in vitro culturing. The methods comprise isolating and culturing hepatocyte precursor cell lines under permissive culture conditions that suppress asymmetric cell kinetics and allow exponential growth of the precursor cells, followed by transferring the hepatocyte precursor cell lines to non-permissive culture conditions that allow expression of asymmetric cell kinetics and induce expression of hepatocyte-specific characteristics.
    Type: Application
    Filed: November 16, 2009
    Publication date: April 8, 2010
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: James L. Sherley, Hsuan-Shu Lee, Gracy G. Crane
  • Hepatocyte precursor cell lines
    Patent number: 7645610
    Abstract: The present invention is directed to methods for readily generating hepatocyte precursor cell lines that retain hepatocyte-specific functions after extensive in vitro culturing. The methods comprise isolating and culturing hepatocyte precursor cell lines under permissive culture conditions that suppress asymmetric cell kinetics and allow exponential growth of the precursor cells, followed by transferring the hepatocyte precursor cell lines to non-permissive culture conditions that allow expression of asymmetric cell kinetics and induce expression of hepatocyte-specific characteristics.
    Type: Grant
    Filed: February 18, 2003
    Date of Patent: January 12, 2010
    Assignee: Massachusetts Institute of Technology
    Inventors: James L. Sherley, Hsuan-Shu Lee, Gracy G. Crane
  • IN VIVO DRUG SCREENING SYSTEM
    Publication number: 20090185980
    Abstract: The present invention provides imaging devices. The present invention also provides in vivo drug screening systems. The present invention further provides a method for in vivo drug screening.
    Type: Application
    Filed: January 23, 2008
    Publication date: July 23, 2009
    Applicant: NATIONAL TAIWAN UNIVERSITY
    Inventors: CHEN-YUAN DONG, HSUAN-SHU LEE, FENG-CHIEH LI, TZU-LIN SUN, YUAN LIU, PO-SHOU CHANG
  • Hepatocyte precursor cell lines
    Publication number: 20040018620
    Abstract: The present invention is directed to methods for readily generating hepatocyte precursor cell lines that retain hepatocyte-specific functions after extensive in vitro culturing. The methods comprise isolating and culturing hepatocyte precursor cell lines under permissive culture conditions that suppress asymmetric cell kinetics and allow exponential growth of the precursor cells, followed by transferring the hepatocyte precursor cell lines to non-permissive culture conditions that allow expression of asymmetric cell kinetics and induce expression of hepatocyte-specific characteristics.
    Type: Application
    Filed: February 18, 2003
    Publication date: January 29, 2004
    Applicant: Massachusetts Institute of Technology
    Inventors: James L. Sherley, Hsuan-Shu Lee, Gracy G. Crane