Abstract: An automated predictive analytics system disclosed herein provides for generating sales leads with lead engagement recommendations. In one implementation, the system determines similarities between fitness, engagement, and intent characteristics of a plurality of target clients and fitness, engagement, and intent characteristics of an entity's existing clients. Subsequently, the system generates recommendations for engagement with the plurality of target clients, wherein components of the recommendations for engagement are based on determined similarities between the fitness, engagement, and intent characteristics of the plurality of target clients and the fitness, engagement, and intent characteristics of the entity's existing clients. The system presents the plurality of leads with the recommendations of engagement to using a graphical user interface (GUI) at the application layer of the system.

Abstract: In alternative embodiments, provided are methods for treating, ameliorating or protecting (preventing) congestive heart failure (CHF) or a diabetes-related cardiac dysfunction, comprising: providing a urocortin 2-encoding and/or a urocortin 3-encoding nucleic acid, transcript or message, or gene, operatively linked to a transcriptional regulatory sequence, optionally contained in an expression vehicle or a vector such as an adeno-associated virus (AAV), e.g., an AAV8 serotype; and administering to an individual or a patient in need thereof, such as a type 2 diabetic (T2DM), e.g., by IV administration, thereby treating, ameliorating or protecting against (preventing) the T2DM and/or the diabetes-related cardiac dysfunction in the individual or patient.

Abstract: The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.

Abstract: The invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient having or at risk of having heart disease or heart failure, or decreased cardiac function, comprising: providing a cyclic adenosine monophosphate-incompetent (cAMP-incompetent) adenylyl cyclase type 6 (AC6) protein or polypeptide (also called “an AC6mut”), or an AC6mut-encoding nucleic acid or a gene operatively linked to a transcriptional regulatory sequence.

Abstract: Data migration from a source data storage system to a target data storage system, where the source and target data storage systems are of two different types, using a virtual file system to store the data at the target data storage system, with the target data storage system being configured to store data in the manner of the source data storage system. In some embodiments, more convenient and efficient data migration can be provided without changing the architecture of an existing data storage system as far as possible.

Abstract: The present invention is a highly stable gear drive adapter featuring a stabilized drive assembly. The drive assembly includes a drive shaft connected to a gear holder assembly, which couples to a gear shaft assembly, which in turn couples to a tool adapter. Each component of the drive assembly stabilizes or is stabilized by another component. A cover aperture and a drive shaft bearing stabilize the drive shaft laterally. Additionally, an interface between a polygonal band on the surface of the drive shaft and a polygonal aperture in the gear holder assembly also stabilizes the drive shaft laterally. A retaining ring and a shaft stop stabilize the drive shaft axially. The gear shaft assembly includes two gear shaft bearings laterally stabilizing a gear shaft and a gear shaft channel that contains the drive shaft bearing. A tool adapter bearing stabilizes the tool adapter.

Abstract: The present invention belongs to the information processing field and discloses a method and apparatus for associating information. The method for associating information comprises: obtaining identification information of a first content; associating the identification information of the first content with a second content, wherein the second content is created for the first content; obtaining identification information of a third content, wherein the third content is an updated version of the first content, the third content containing revision made according to the second content; and associating the identification information of the third content with the second content. With the method and system for associating information as provided by the present invention, contents of a plurality of versions can be managed and traced efficiently without a need to modify the existing code review flow.

Abstract: The disclosure provides a heat source tower heat pump realizing solution regeneration and heat reutilization based on vacuum boiling. It comprises a refrigerant circuit, a solution circuit, a vacuum maintenance circuit, an air circuit, a regenerative solution heating circuit and a cold/hot water circuit. The unit provided by the disclosure regenerates a solution by taking full advantage of the characteristic that the boiling point of a solution will be reduced in vacuum, uses the heat released from the cooling of overheated refrigerant as the heat of solution regeneration and also uses the heat to produce heat supply hot water.

Abstract: In alternative embodiments, the invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient against a disease, an infection or a condition responsive to an increased paracrine polypeptide level in vivo comprising: providing a paracrine polypeptide-encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence; or an expression vehicle, a vector, a recombinant virus, or equivalent, having contained therein a paracrine-encoding nucleic acid or gene, and the expression vehicle, vector, recombinant virus, or equivalent can express the paracrine-encoding nucleic acid or gene in a cell or in vivo; and administering or delivering the paracrine polypeptide-encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence, or the expression vehicle, vector, recombinant virus, or equivalent, to an individual or a patient in need thereof, thereby treating, ameliorating or protecting (preventing) the individual or patient a

Abstract: A gear-driver adapter configured to switch between at least two gear ratios includes a switch which exerts a force on a drive shaft to move the drive shaft between at least two positions, each corresponding to a gear ratio, in an epicyclic gear system created by a main gear body, ball driver and gear holder with gears. The drive shaft contains keyed structures and, depending on its position within the gear system, the keyed structures on the drive shaft engage or disengage a plurality of key stops. The key stops, in turn, interact with the gears to generate the desired gear ratio. The contours of the keyed structures on the gear holder allow the drive shaft to move between positions without first being specifically positioned. The gear-driver adapter also includes a handle adapter and a driver adapter, allowing users to use any handle or driver with the gear-driver adapter.

Abstract: The present invention is a self-locking internal adapter for D-shaped orthopedic tools. A locking ball mechanism prevents movement of the adapter components relative to each other, while a plurality of securing ball mechanisms releasably secure a D-shaped orthopedic tool in the adapter. A chamfered surface of the adapter engages a chamfer of the tool to centrally stabilize the tool in the adapter. The internal adapter may be used with driver handles, ratcheting handles and torque-limiting handles.

Abstract: The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.

Abstract: An internal adapter for use in torque-limiting handles for interchangeable orthopedic tools contains a slidable collar component, house component, retaining ring, spring, driver component, cover and cam which engages a torque-limiting mechanism. A plurality of securing ball mechanisms releasably secure an orthopedic tool in the adapter, while a configuration of chamfered surfaces centrally stabilize the tool. A plurality of guiding chamfers located in a driver component rotationally secures the orthopedic tool.

Abstract: A gripping device with a precision ratcheting mechanism includes an upper and a lower arm, each terminating in a U-shaped receiver, connected by a pair of pivotal joints. A pawl device is pivotally connected to the U-shaped receiver of the upper arm, while a post, passing through the pawl device, is pivotally connected to the lower arm. The post contains a plurality of teeth on one surface and a teeth-engaging member in the pawl device contains a plurality of corresponding teeth which engage the teeth on the post. The teeth are disengaged by pressing a release surface, which compresses a spring and physically moves the teeth-engaging structure away from the post, allowing the post to move freely within the pawl device.

Abstract: A powder lime calcining process comprises: transporting fine granules of limestones having a water content less than 4%, and a granule size less than 15 mm, from a raw material storing bin to a small material bin, transporting the materials from the small material bin into an airflow pipe by a belt conveyer, heating and drying the materials, sieving the materials by a sieving device, transporting granules into a cyclone cylinder deduster and a clothbag deduster in turn by airflow pipes, the fine powders of limestones after dedusted are transported into an intermediate bin; the materials within the intermediate bin are transported to four preheating cyclone cylinders by a pneumatic lift pump and airflow pipes, and are preheated and separated; the materials after separated are transported into three cooling cyclone cylinders for cooling and separating the materials, finally transported into a finished product bin by a finished product transporting system.

Abstract: An internal adapter for use in handles for interchangeable orthopedic tools contains a collar assembly, house assembly, retaining ring, spring and driver assembly. A plurality of securing ball mechanisms releasably secure an orthopedic tool in the adapter, while a configuration of chamfered surfaces centrally stabilize the tool. A plurality of guiding chamfers located in a shaft driver assembly rotationally secures the orthopedic tool.

Abstract: Disclosed herein are system, method and apparatus with environmental noise cancellation. The instant disclosure is particularly adapted to a receiver module having at least two inputs. The two inputs respectively receive a main audio portion and the audio with majority of environmental noise. The system firstly calibrates the audio signals to reduce the error caused by the difference between the two inputs. An adaptive beamforming technology and a speech extractor are respectively used to extract the environmental noise portion with less main audio and the main audio portion with less noise. After a process of time-to-frequency domain transformation, a non-linear noise suppression technology is introduced into estimating the environmental noise and acquiring a gain. After noise suppression processed with the gain, a sequence of audio signals is output after a frequency-to-time domain transformation.

Abstract: Semiconductor devices and methods are provided. The semiconductor device can include a semiconductor substrate, a plurality of solder pads disposed on the semiconductor substrate, a first insulating layer disposed over the semiconductor substrate, a columnar electrode disposed over the solder pad, and a solder ball disposed on the columnar electrode. The first insulating layer can include a first opening to expose a solder pad of the plurality of solder pads. The columnar electrode can include a bulk material and a through hole in the bulk material. The through hole can expose at least a surface portion of the solder pad. The solder ball can include a convex metal head on a top surface of the bulk material of the columnar electrode, and a filling part filled in the through hole.

Abstract: A method is disclosed for treating diseases or disorders of the eye involving undesired neovascularization by administration of a complement inhibitory protein such as soluble complement receptor type I (sCR1). The present invention relates to the direct treatment of macular degeneration, particularly age-related macular degeneration (AMD), by administering a complement inhibitory protein intraocularly or systemically.