Abstract: This disclosure is directed to a pharmaceutical composition comprises tumor inhibiting cells (TICs) and a method for producing the TICs. The tumor inhibiting cells can be derived from immune cells including T cells, NK cells, or a combination thereof, modified to have inactivated Cbl-b gene alleles and free from Cbl-b bio-function (Cbl-b?/? TICs). The Cbl-b?/? TICs are free from deoxyribonucleic acids exogenous to the immune cells. The immune cells can be isolated using a portable cell isolation and modification device. This disclosure is further directed to a method for treating tumorous conditions in subjects. The pharmaceutical composition can provide a subject-specific tumor treatment.

Abstract: A backlight module and a display device are provided. A light reflection layer is disposed at a backlight side of a through-hole region. And the light reflection layer is disposed at an inner side of an iron frame. After a reflection surface (i.e., a first light-reflecting region) receiving light from a backlight source, the light is reflected to the backlight side of the through-hole to brighten the backlight side. The first light-reflecting region enables a relatively dark area of the backlight side to obtain stronger reflection light, and enables a relatively bright area of the backlight side to obtain weaker reflection light, so that a brightness is uniformly distributed after the backlight side being brightened, thereby achieving a brightening effect.

Abstract: This invention concerns a series of excipients capable of effectively reducing the viscosity of protein formulations. The viscosity reducing excipients are oligopeptides (e.g., dipeptides, tripeptides) comprising at least one arginine. The peptides may also include basic or acidic or hydrophilic or hydrophobic/aromatic amino acids. An arginine residue may be either at the amino or the carboxyl end of the oligopeptide.

Abstract: Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.

Abstract: The invention provides an isolated, purified population of human cells comprising CD8+ T cells with reduced Cbl-b activity. The invention provides uses of such cells in methods for inducing or enhancing an anti-tumor immune response in a subject. These methods comprise: (a) providing a cell population, from a subject or from another source, which comprises CD8+ T cells, (b) reducing Cbl-b activity in the CD8+ T-cells, (c) administering the cells of step (b) to the subject. The invention provides methods for making CD8+ T cells that do not require stimulation through a co-receptor in order for the cell to become activated or proliferated in response to contact via its T cell receptor. Such methods are based upon reducing function of Cbl-b. The invention also provides methods for identifying agents which affect Cbl-b expression or activity.

Abstract: An oscillating power tool, including a housing; a motor; a drive shaft driven by the motor; an output shaft driven by the drive shaft; a transmission mechanism for converting rotary motion of the drive shaft into oscillation of the output shaft, wherein the transmission mechanism includes an eccentric device mounted on the drive shaft and a shifting fork assembly connecting the eccentric device with the output shaft; the eccentric device includes at least two drive members, the shifting fork assembly includes a shifting fork member connected to the output shaft and a supporting member movably connected to the shifting fork member, the supporting member includes a matching portion, the oscillating power tool further includes an adjusting mechanism disposed in the housing, and the adjusting mechanism operably adjusts the supporting member to move, such that the matching portion is selectively abutted against different drive members.

Abstract: The present disclosure discloses a corner protector including a strip-shaped corner bead and a connector for connecting the corner bead, wherein the corner bead encloses a rectangular area, and the connector is connected between two adjacent sides of the corner beads. The corner protector of the present disclosure adopts a connector to connect the corner bead with higher hardness, which can ensure that the top edge of the package structure has higher hardness and is not easily broken. The corner protector can be split and assembled as needed, has the advantages of low cost, simple manufacture, simple transportation and storage, and convenient assembly and use.

Abstract: Optically transparent films can comprise a coating of nanodiamonds to introduce desirable properties, such as hardness, good thermal conductivity and an increased dielectric constant. In general, transparent conductive films can be formed with desirable property enhancing nanoparticles included in a transparent conductive layer and/or in a coating layer. Property enhancing nanoparticles can be formed from materials having a large hardness parameter, a large thermal conductivity and/or a large dielectric constant. Suitable polymers are incorporated as a binder in the layers with the property enhancing nanoparticles. The coatings with property enhancing nanoparticles can be solution coated and corresponding solutions are described.

Abstract: The invention provides an isolated, purified population of human cells comprising CD8+ T cells with reduced Cbl-b activity. The invention provides uses of such cells in methods for inducing or enhancing an anti-tumor immune response in a subject. These methods comprise: (a) providing a cell population, from a subject or from another source, which comprises CD8+ T cells, (b) reducing Cbl-b activity in the CD8+ T-cells, (c) administering the cells of step (b) to the subject. The invention provides methods for making CD8+ T cells that do not require stimulation through a co-receptor in order for the cell to become activated or proliferated in response to contact via its T cell receptor. Such methods are based upon reducing function of Cbl-b. The invention also provides methods for identifying agents which affect Cbl-b expression or activity.

Abstract: The present invention provides a jointed package corner protector, which includes corner plates (1) each of which is formed, in two opposite, upper and lower, ends thereof, with first through holes (11) that are perpendicular to a lengthwise direction of the corner plates (1) and a joint sheath (31) that is formed with second through holes (311) that correspond to the first through holes (11) formed in an upper end of a lower-side corner plate (1) of two corner plates (1) that are arranged adjacent to each other as being respectively set at upper and lower sides and the first through holes (11) formed in a lower end of the upper-side corner plate (1) so that button fasteners (33) may be set to penetrate through corresponding ones of the first through holes (11) and the second through holes (311) to connect the two adjacent corner plates (1) of the upper and lower sides to the joint sheath (31), whereby easy variation of a length of the package corner protector can be achieved accommodate stacked heights of di

Abstract: The present disclosure discloses a corner protector including a strip-shaped corner bead and a connector for connecting the corner bead, wherein the corner bead encloses a rectangular area, and the connector is connected between two adjacent sides of the corner beads. The corner protector of the present disclosure adopts a connector to connect the corner bead with higher hardness, which can ensure that the top edge of the package structure has higher hardness and is not easily broken. The corner protector can be split and assembled as needed, has the advantages of low cost, simple manufacture, simple transportation and storage, and convenient assembly and use.

Abstract: The invention provides an isolated, purified population of human cells comprising CD8+ T cells with reduced Cbl-b activity. The invention provides uses of such cells in methods for inducing or enhancing an anti-tumor immune response in a subject. These methods comprise: (a) providing a cell population, from a subject or from another source, which comprises CD8+ T cells, (b) reducing Cbl-b activity in the CD8+ T-cells, (c) administering the cells of step (b) to the subject. The invention provides methods for making CD8+ T cells that do not require stimulation through a co-receptor in order for the cell to become activated or proliferated in response to contact via its T cell receptor. Such methods are based upon reducing function of Cbl-b. The invention also provides methods for identifying agents which affect Cbl-b expression or activity.

Abstract: A method of transferring nanomaterials with sugar, the method including: depositing a colloidal sugar layer on a first substrate; pressing a second substrate and a nanomaterial layer located on the second substrate on the colloidal sugar layer, wherein the nanomaterial layer is adhered to the colloidal sugar layer; solidifying the colloidal sugar layer into a solid sugar layer; tearing the second substrate; locating a fourth substrate on the nanomaterial layer; placing the first substrate, the solid sugar layer, the nanomaterial layer and the fourth substrate in a solvent, wherein the solid sugar layer is dissolved in the solvent, and the nanomaterial layer is detached from the first substrate and attached to the fourth substrate.

Abstract: An ultra-narrow bezel backlight module is provided in the present application, including a light guide plate, a light source, a light-shielding layer and an optical film set, wherein the light source is an edge type light source, and is disposed at a light incident end of the light guide plate, the optical film set is disposed on a light emitting surface of an upper surface of the light guide plate, the light-shielding layer is adhered to an edge and an end surface of an upper surface of the optical film set and is wrapped to an end surfaces of each non-light incident ends and an edge of a lower surface of the light guide plate. A display panel is also provided in the present application.

Abstract: An oscillatory power tool that is capable of using various types of cutting tools is disclosed. The power tool includes an output shaft for mounting one of the cutting tools and driving the cutting tool in an oscillating rotary motion. An end of the output shaft has a driving section for engaging with a securing section of the cutting tool. The power tool further includes a fastener connected to the output shaft at the end and connectable to the securing section of the cutting tool for fastening the cutting tool to the end of the output shaft. The driving section has a fitting surface for contacting a surface of the securing section. Through a close fit between the friction surface and the surface of the securing section, the power tool can be connected with different types of cutting tools, which greatly improves the universality and convenience of the power tool.

Abstract: Fusing nanowire inks are described that can also comprise a hydrophilic polymer binder, such as a cellulose based binder. The fusing nanowire inks can be deposited onto a substrate surface and dried to drive the fusing process. Transparent conductive films can be formed with desirable properties.

Abstract: A method for monitoring quality of a hydraulic fluid in an electro-hydraulic (EH) valve is disclosed. The method includes applying predetermined signal to a solenoid coil, surrounding a pusher pin in EH valve, to facilitate oscillation of a pusher pin in EH valve to change static friction between the pusher pin and a cavity of EH valve, to dynamic friction. EH valve includes a housing defining the cavity having an end wall. Cavity slidably receiving the pusher pin having a first end and a second end. The hydraulic fluid is received between the first end of the pusher pin and the end wall. The oscillation of the pusher pin generates an acoustic wave that propagates through the hydraulic fluid. The method further includes determining the quality of the hydraulic fluid based on one or more characteristics of the acoustic wave detected by an acoustic sensor positioned on the end wall.

Abstract: The present invention provides a jointed package corner protector, which includes corner plates (1) each of which is formed, in two opposite, upper and lower, ends thereof, with first through holes (11) that are perpendicular to a lengthwise direction of the corner plates (1) and a joint sheath (31) that is formed with second through holes (311) that correspond to the first through holes (11) formed in an upper end of a lower-side corner plate (1) of two corner plates (1) that are arranged adjacent to each other as being respectively set at upper and lower sides and the first through holes (11) formed in a lower end of the upper-side corner plate (1) so that button fasteners (33) may be set to penetrate through corresponding ones of the first through holes (11) and the second through holes (311) to connect the two adjacent corner plates (1) of the upper and lower sides to the joint sheath (31), whereby easy variation of a length of the package corner protector can be achieved accommodate stacked heights of di

Abstract: An oscillating power tool, including a housing; a motor; a drive shaft driven by the motor; an output shaft driven by the drive shaft; a transmission mechanism for converting rotary motion of the drive shaft into oscillation of the output shaft, wherein the transmission mechanism includes an eccentric device mounted on the drive shaft and a shifting fork assembly connecting the eccentric device with the output shaft; the eccentric device includes at least two drive members, the shifting fork assembly includes a shifting fork member connected to the output shaft and a supporting member movably connected to the shifting fork member, the supporting member includes a matching portion, the oscillating power tool further includes an adjusting mechanism disposed in the housing, and the adjusting mechanism operably adjusts the supporting member to move, such that the matching portion is selectively abutted against different drive members.

Abstract: The invention provides an isolated, purified population of human cells comprising CD8+ T cells with reduced Cbl-b activity. The invention provides uses of such cells in methods for inducing or enhancing an anti-tumor immune response in a subject. These methods comprise: (a) providing a cell population, from a subject or from another source, which comprises CD8+ T cells, (b) reducing Cbl-b activity in the CD8+ T-cells, (c) administering the cells of step (b) to the subject. The invention provides methods for making CD8+ T cells that do not require stimulation through a co-receptor in order for the cell to become activated or proliferated in response to contact via its T cell receptor. Such methods are based upon reducing function of Cbl-b. The invention also provides methods for identifying agents which affect Cbl-b expression or activity.