Patents by Inventor Hubert A. Nienaber

Hubert A. Nienaber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMMR (SMALL MOLECULE METABOLITE REPORTERS) FOR USE AS IN VIVO GLUCOSE BIOSENSORS
    Publication number: 20140127137
    Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
    Type: Application
    Filed: June 17, 2013
    Publication date: May 8, 2014
    Applicant: Cercacor Laboratories, Inc
    Inventors: Emile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
  • SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
    Patent number: 8466286
    Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: June 18, 2013
    Assignee: Cercacor Laboratories, Inc.
    Inventors: Emile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
  • SMMR (SMALL MOLECULE METABOLITE REPORTERS) FOR USE AS IN VIVO GLUCOSE BIOSENSORS
    Publication number: 20120052018
    Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
    Type: Application
    Filed: August 22, 2011
    Publication date: March 1, 2012
    Applicant: Masimo Laboratories, Inc.
    Inventors: Emile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
  • SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
    Patent number: 8029765
    Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: October 4, 2011
    Assignee: Masimo Laboratories, Inc.
    Inventors: Emile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
  • SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
    Patent number: 8008088
    Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: August 30, 2011
    Assignee: Masimo Laboratories, Inc.
    Inventors: Emile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
  • Smmr (Small Molecule Metabolite Reporters) For Use As In Vivo Glucose Biosensors
    Publication number: 20090004108
    Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
    Type: Application
    Filed: December 23, 2004
    Publication date: January 1, 2009
    Applicant: Masimo Laboratories, Inc.
    Inventors: Emile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
  • SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
    Publication number: 20070110672
    Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
    Type: Application
    Filed: June 26, 2006
    Publication date: May 17, 2007
    Inventors: Emile Bellott, Dongsheng Bu, James Childs, Christopher Lambert, Hubert Nienaber, Shirley Shi, Zhaolin Wang, Jerome Workman, Alex Zelenchuk
  • Device and method for the determination of lithium ion concentration in a biological fluid
    Patent number: 7214538
    Abstract: The present invention relates to a novel device and method for the detection of lithium ions in a biological fluid. In a preferred embodiment, the present invention provides a novel compound and a optical sensor which incorporates said compound for the detection of lithium ions. Additionally, the present invention provides a method of detecting lithium ions which comprises placing the novel optical sensor into communication with a biological fluid. Once the novel compound of the present invention encounters a lithium ion(s), a fluorescence is generated, the intensity of which is measured and allows for the determination of lithium ion concentration. The present invention provides a medical professional with the ability to selectively determine lithium ion concentration in a biological fluid thereby facilitating the treatment of various diseases, such as manic-depressive illness.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: May 8, 2007
    Assignees: Worcester Polytechnic Institute, Bayer Health Care, LLC.
    Inventors: John S. Benco, Hubert A. Nienaber, W. Grant McGimpsey
  • Device and method for the determination of lithium ion concentration in a biological fluid
    Publication number: 20040161854
    Abstract: The present invention relates to a novel device and method for the detection of lithium ions in a biological fluid. In a preferred embodiment, the present invention provides a novel compound and a optical sensor which incorporates said compound for the detection of lithium ions. Additionally, the present invention provides a method of detecting lithium ions which comprises placing the novel optical sensor into communication with a biological fluid. Once the novel compound of the present invention encounters a lithium ion(s), a fluorescence is generated, the intensity of which is measured and allows for the determination of lithium ion concentration. The present invention provides a medical professional with the ability to selectively determine lithium ion concentration in a biological fluid thereby facilitating the treatment of various diseases, such as manic-depressive illness.
    Type: Application
    Filed: February 11, 2004
    Publication date: August 19, 2004
    Applicants: Bayer HealthCare LLC, Worcester Polytechnic Institute
    Inventors: John S. Benco, Hubert A. Nienaber, W. Grant McGimpsey
  • Potassium fluoroionophore
    Patent number: 6660526
    Abstract: A fluoroionophore for the fluorescent detection of potassium ions.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: December 9, 2003
    Assignees: Bayer Corporation, Worcester Polytechnic Institute
    Inventors: John S. Benco, W. Grant McGimpsey, Hubert Nienaber
  • Potassium fluoroionophore
    Publication number: 20030119195
    Abstract: A fluoroionophore for the fluorescent detection of potassium ions.
    Type: Application
    Filed: December 21, 2001
    Publication date: June 26, 2003
    Inventors: John S. Benco, W. Grant McGimpsey, Hubert Nienaber