Patents by Inventor Hubert M Quinn
Hubert M Quinn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11237138Abstract: The present disclosure is directed at the selection and design of columns for liquid chromatography including liquid chromatography devices and systems and corresponding methods of operation, particularly in the field of high pressure liquid chromatography (HPLC).Type: GrantFiled: June 19, 2019Date of Patent: February 1, 2022Assignee: THE WRANGLER GROUPInventor: Hubert M. Quinn
-
Publication number: 20200400625Abstract: The present disclosure is directed at the selection and design of columns for liquid chromatography including liquid chromatography devices and systems and corresponding methods of operation, particularly in the field of high pressure liquid chromatography (HPLC).Type: ApplicationFiled: June 19, 2019Publication date: December 24, 2020Inventor: Hubert M. Quinn
-
Patent number: 7767463Abstract: A method and system of screening or selecting a mobile phase eluent for a chromatography column is provided. A sample for chromatographic analysis or purification is combined with a solvent and passed through a membrane. A pressure measurement is taken of the sample/solvent combination in the system prior to the membrane. The pressure measurement may be compared to a second pressure and an appropriate solvent may be selected based on the relationship between the first measured pressure and the second pressure.Type: GrantFiled: June 15, 2007Date of Patent: August 3, 2010Assignee: Cohesive Technologies, Inc.Inventors: Hubert M Quinn, Joseph J. Takarewski, Jr., Elizabeth Williams
-
Publication number: 20080307861Abstract: A method and system of screening or selecting a mobile phase eluent for a chromatography column is provided. A sample for chromatographic analysis or purification is combined with a solvent and passed through a membrane. A pressure measurement is taken of the sample/solvent combination in the system prior to the membrane. The pressure measurement may be compared to a second pressure and an appropriate solvent may be selected based on the relationship between the first measured pressure and the second pressure.Type: ApplicationFiled: June 15, 2007Publication date: December 18, 2008Applicant: COHESIVE TECHNOLOGIES, INC.Inventors: Hubert M. QUINN, Joseph J. TAKAREWSKI, JR., Elizabeth WILLIAMS
-
Patent number: 6149816Abstract: A system for separating compounds of relatively low molecular weight substantially not greater than about one kilodalton from compounds having relatively high molecular weights substantially an order of magnitude greater or more than the low molecular weight compounds in a liquid mixture. The system includes a chromatographic column packed with uniformly distributed rigid, solid, porous particles having chromatographically active, hydrophobic surfaces, average diameters of not less than about 30 .mu.m, and average pore diameters sufficiently small to substantially exclude introduction of the compounds of relatively high molecular weight into the pores. The mixture is pumped through the interstitial volume between the particles at a reduced velocity greater than about 5,000, until a band of the high molecular weight compounds exits the column. The low molecular weight compounds are then eluted and are recovered separately from the relatively high molecular weight compounds.Type: GrantFiled: January 3, 2000Date of Patent: November 21, 2000Assignee: Cohesive Technologies, Inc.Inventors: Hubert M. Quinn, John E. Brann, III
-
Patent number: 6110362Abstract: A system for separating compounds of relatively low molecular weight substantially not greater than about one kilodalton from compounds having relatively high molecular weights substantially an order of magnitude greater or more than the low molecular weight compounds in a liquid mixture. The system includes a chromatographic column packed with uniformly distributed rigid, solid, porous particles having chromatographically active, hydrophobic surfaces, average diameters of not less than about 30 .mu.m, and average pore diameters sufficiently small to substantially exclude introduction of the compounds of relatively high molecular weight into the pores. The mixture is pumped through the interstitial volume between the particles at a reduced velocity greater than about 5,000, until a band of the high molecular weight compounds exits the column. The low molecular weight compounds are then eluted and are recovered separately from the relatively high molecular weight compounds.Type: GrantFiled: November 19, 1997Date of Patent: August 29, 2000Assignee: Cohesive Technologies, Inc.Inventors: Hubert M. Quinn, John E. Brann, III
-
Patent number: 5968367Abstract: High pressure liquid chromatographic apparatus in which a fluid mixture containing at least one solute that is reactive with chromatographically reactive surfaces in the column is loaded into the column, and a number of plugs of different eluant fluids are injected into that column. The injections are made in a manner that minimizes the amount of eluant required. In one embodiment, the injections are made to insure that flow of at least the eluant fluids through the column will occur, preferably with a substantially flat wave front, at speeds corresponding to reduced velocities greater than about 5,000, i.e. at flow rates sufficient to induce turbulent flow in those fluids, thereby minimizing the time required for the entire succession of mixture and eluant fluids to traverse the column.Type: GrantFiled: January 7, 1998Date of Patent: October 19, 1999Assignee: Cohesive Technologies, Inc.Inventors: Hubert M. Quinn, Rebecca A. Menapace, Charles J. Oberhauser
-
Patent number: 5919368Abstract: A method of and apparatus for liquid chromatography at improved analytical and preparative speeds and quantities involves flow of fluids through the column at flow rates sufficient to induce turbulent flow in those fluids. In one embodiment, the apparatus and method includes a substantially uniform chromatography column created by packing together a multiplicity of rigid, solid, porous particles having diameters of not less than about 30 .mu.m, surfaces of the particles being chromatographically active. A fluid mixture containing at least one solute that is reactive with the particle surfaces is injected into the column and subsequently eluted therefrom by a eluant fluid flow, both the injection and elution being effected at a velocity sufficient to induce flow within at least a substantial portion of the interstitial volume between the particles at a reduced velocity greater than about 5,000.Type: GrantFiled: December 8, 1997Date of Patent: July 6, 1999Assignee: Cohesive Technologies, Inc.Inventors: Hubert M. Quinn, Joseph J. Takarewski, Jr.
-
Patent number: 5795469Abstract: High pressure liquid chromatographic apparatus in which a fluid mixture containing at least one solute that is reactive with chromatographically reactive surfaces in the column is loaded into the column, and a number of plugs of different eluant fluids are injected into that column. The injections are made in a manner that minimizes the amount of eluant required. In one embodiment, the injections are made to insure that flow of at least the eluant fluids through the column will occur, preferably with a substantially flat wave front, at speeds corresponding to reduced velocities greater than about 5,000, i.e. at flow rates sufficient to induce turbulent flow in those fluids, thereby minimizing the time required for the entire succession of mixture and eluant fluids to traverse the column.Type: GrantFiled: January 21, 1997Date of Patent: August 18, 1998Assignee: Cohesive Technologies, Inc.Inventors: Hubert M. Quinn, Rebecca A. Menapace, Charles J. Oberhauser
-
Patent number: 5772874Abstract: A method of and apparatus for liquid chromatography at improved analytical and preparative speeds and quantities involves flow of fluids through the column at flow rates sufficient to induce turbulent flow in those fluids. In one embodiment, the apparatus and method includes a substantially uniform chromatography column created by packing together a multiplicity of rigid, solid, porous particles having diameters of not less than about 30 .mu.m, surfaces of the particles being chromatographically active. A fluid mixture containing at least one solute that is reactive with the particle surfaces is injected into the column and subsequently eluted therefrom by a eluant fluid flow, both the injection and elution being effected at a velocity sufficient to induce flow within at least a substantial portion of the interstitial volume between the particles at a reduced velocity greater than about 5,000.Type: GrantFiled: June 11, 1996Date of Patent: June 30, 1998Assignee: Cohesive Technologies, Inc.Inventors: Hubert M. Quinn, Joseph J. Takarewski, Jr.