Patents by Inventor Hubert Maehr
Hubert Maehr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10342315Abstract: A lipstick tube that can be worn as an attachment to wearable object, such as a necklace, with the intermediacy of a coupling system wherein the lipstick tube is readily connect and disconnect to and from the necklace, and wherein the resulting arrangement is tailored to athletic and outdoor activities with built-in resistance of the tube toward loss of the lipstick by unintentional pulling, or wherein the arrangement is intended as an ornate display of charm and grace and targeted primarily to female users where elegance and practicality is supported by the coupling system. The choice tubes can be provided with refill capabilities to encourage use of valuable construction materials, to guarantee their value and usefulness over a long lifetime, to enlarge the repertoire of available lipstick colors and chemical compositions for the user, and to encourage eco-friendliness.Type: GrantFiled: April 29, 2015Date of Patent: July 9, 2019Inventor: Hubert Maehr
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Publication number: 20160316887Abstract: A lipstick tube that can be worn as an attachment to wearable object, such as a necklace, with the intermediacy of a coupling system wherein the lipstick tube is readily connect and disconnect to and from the necklace, and wherein the resulting arrangement is tailored to athletic and outdoor activities with built-in resistance of the tube toward loss of the lipstick by unintentional pulling, or wherein the arrangement is intended as an ornate display of charm and grace and targeted primarily to female users where elegance and practicality is supported by the coupling system. The choice tubes can be provided with refill capabilities to encourage use of valuable construction materials, to guarantee their value and usefulness over a long lifetime, to enlarge the repertoire of available lipstick colors and chemical compositions for the user, and to encourage eco-friendliness.Type: ApplicationFiled: April 29, 2015Publication date: November 3, 2016Inventor: Hubert Maehr
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Patent number: 9249107Abstract: The invention relates to a compound of the formula wherein the substituents are as defined herein, and a pharmaceutically acceptable salt of the compound of formula (1). The compounds of formula (1) and their salts possess inflammation inhibiting properties and are therefore useful in the treatment and prevention of conditions related to inflammations such as inflammatory joint diseases. The compounds of formula (1) are also useful for the treatment of diseases where chronic inflammation is the underlying cause. This application relates to compounds of formula (1), methods for their preparation, pharmaceutical compositions comprising these compounds, and their use for the preparation of a medicament for the treatment of humans and animals.Type: GrantFiled: September 20, 2013Date of Patent: February 2, 2016Inventor: Hubert Maehr
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Publication number: 20150087665Abstract: The invention relates to a compound of the formula wherein the substituents are as defined herein, and a pharmaceutically acceptable salt of the compound of formula (1). The compounds of formula (1) and their salts possess inflammation inhibiting properties and are therefore useful in the treatment and prevention of conditions related to inflammations such as inflammatory joint diseases. The compounds of formula (1) are also useful for the treatment of diseases where chronic inflammation is the underlying cause. This application relates to compounds of formula (1), methods for their preparation, pharmaceutical compositions comprising these compounds, and their use for the preparation of a medicament for the treatment of humans and animals.Type: ApplicationFiled: September 20, 2013Publication date: March 26, 2015Inventor: Hubert Maehr
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Patent number: 8853248Abstract: The invention relates to a compound of the formula wherein the substituents are as defined herein, and pharmaceutically acceptable salts of the compound of formula (1). The compounds of formula (1), and their salts, possess inflammation inhibiting properties and are therefore useful in the treatment and prevention of conditions related to inflammations, such as inflammatory joint diseases, or other diseases caused by chronic inflammation. This application relates to compounds of formula (1), methods for their preparation, pharmaceutical compositions comprising these compounds and their use for the preparation of medicaments for the treatment of humans and animals.Type: GrantFiled: April 5, 2012Date of Patent: October 7, 2014Inventors: Hubert Maehr, Donchu Wei
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Patent number: 8580805Abstract: The invention relates to a compound of the formula wherein the substituents are as defined herein, and a pharmaceutically acceptable salt of the compound of formula (1). The compounds of formula (1) and their salts possess inflammation inhibiting properties and are therefore useful in the treatment and prevention of conditions related to inflammations such as inflammatory joint diseases. The compounds of formula (1) are also useful for the treatment of diseases where chronic inflammation is the underlying cause. This application relates to compounds of formula (1), methods for their preparation, pharmaceutical compositions comprising these compounds, and their use for the preparation of a medicament for the treatment of humans and animals.Type: GrantFiled: August 30, 2011Date of Patent: November 12, 2013Inventor: Hubert Maehr
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Publication number: 20130267568Abstract: The invention relates to a compound of the formula wherein the substituents are as defined herein, and pharmaceutically acceptable salts of the compound of formula (1). The compounds of formula (1), and their salts, possess inflammation inhibiting properties and are therefore useful in the treatment and prevention of conditions related to inflammations, such as inflammatory joint diseases, or other diseases caused by chronic inflammation. This application relates to compounds of formula (1), methods for their preparation, pharmaceutical compositions comprising these compounds and their use for the preparation of medicaments for the treatment of humans and animals.Type: ApplicationFiled: April 5, 2012Publication date: October 10, 2013Inventors: Hubert Maehr, Donchu Wei
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Publication number: 20120053346Abstract: The invention relates to a compound of the formula wherein the substituents are as defined herein, and a pharmaceutically acceptable salt of the compound of formula (1). The compounds of formula (1) and their salts possess inflammation inhibiting properties and are therefore useful in the treatment and prevention of conditions related to inflammations such as inflammatory joint diseases. The compounds of formula (1) are also useful for the treatment of diseases where chronic inflammation is the underlying cause. This application relates to compounds of formula (1), methods for their preparation, pharmaceutical compositions comprising these compounds, and their use for the preparation of a medicament for the treatment of humans and animals.Type: ApplicationFiled: August 30, 2011Publication date: March 1, 2012Inventor: Hubert Maehr
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Publication number: 20090137828Abstract: The invention provides a method of producing 20-methyl vitamin D3 compounds of formula (I). The method includes allylic and olefin oxidation, de-carbonylation, carbonyl reduction, fluoride substitution, epoxide deoxygenation, and Wittig-type couplings.Type: ApplicationFiled: August 18, 2006Publication date: May 28, 2009Applicant: BIOXELL S.P.A.Inventors: Milan R. Uskokovic, Stanislaw Marczak, Ralf Loo, Marcel Van Der Sluis, Pawel Jankowski, Hubert Maehr
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Publication number: 20080280859Abstract: The invention provides Gemini vitamin D3 compounds, methods for using the compounds to treat vitamin D3 associated states and pharmaceutical compositions containing the compounds.Type: ApplicationFiled: October 19, 2005Publication date: November 13, 2008Applicant: BioXell S.p.A.Inventors: Luciano Adorini, Giuseppe Penna, Milan R. Uskokovic, Hubert Maehr
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Publication number: 20070032461Abstract: The invention provides 1,3 acylated, 24-keto vitamin D3 compounds of formula I: wherein: X1 and X1 are each independently H2 or ?CH2, provided X1 and X1 are not both ?CH2; R1 and R2 are each independently, hydroxyl, OC(O)C1-C4 alkyl, OC(O)hydroxyalkyl, OC(O)haloalkyl, provided that R1 and R2 are not both hydroxyl; R3 and R4 are each independently hydrogen, C1-C4 alkyl, hydroxyalkyl, or haloalkyl, or R3 and R4 taken together with C20 form C3-C6 cylcoalkyl; and R5 and R6 are each independently C1-C4 alkyl, hydroxyalkyl, or haloalkyl; and pharmaceutically acceptable esters, salts, and prodrugs thereof. Methods for using the compounds to treat vitamin D3 associated states, and phar,aceutical compositions containing the compounds are also disclosed.Type: ApplicationFiled: April 30, 2004Publication date: February 8, 2007Applicant: BioXell S.p.A.Inventors: Luciano Adorini, Giuseppe Penna, Milan Uskokovic, Hubert Maehr
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Patent number: 6232471Abstract: This invention relates to new processes for manufacturing 4-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-N-methyl-3H-[1,2,3]triazole-5-carboxamide (compound I) as well as the following new intermediates useful in these synthetic processes. 2-benzenesulfonyl-N-methylacetamide (compound IV), 2-(benzenesulfonyl)-3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-N-methylacrylamide (compound II) and threo-2-[2-benzenesulfonyl-1-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[(methylcarbamoyl)ethyl]]-5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-N-methyl-2H-[1,2,3]triazole-4-carboxamide (compound III).Type: GrantFiled: November 19, 1999Date of Patent: May 15, 2001Assignee: Hoffmann-La Roche Inc.Inventor: Hubert Maehr
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Patent number: 5637720Abstract: The invention relates to a process of making a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 and n are as described herein, and, when R.sub.1 is different from R.sub.2, and/or when R.sub.3 is different from R.sub.4, enantiomers, diastereomers and racemates thereof, and salts thereof with pharmaceutically acceptable bases. The method comprises reacting a compound of the formula ##STR2## wherein R.sub.5 and n are as described herein with a compound of the formula ##STR3## to produce a compound of the formula ##STR4## wherein n is as described herein, and converting a compound of formula IV to a compound of formula I.Type: GrantFiled: May 28, 1996Date of Patent: June 10, 1997Assignee: Hoffmann-La Roche Inc.Inventor: Hubert Maehr
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Patent number: 5523310Abstract: The invention relates to a compound of the formula ##STR1## wherein the substituents are as defined herein; its tautomer wherein the hydrogen of the triazole ring occupies position 1 of the triazole ring, and a pharmaceutically acceptable salt of the compound of formula I wherein R.sup.3 is --OH or its tautomer wherein the hydrogen of the triazole ring occupies position 1 of the triazole ring. The compounds of formula I and their salts possess inflammation inhibiting properties and are therefore useful in the treatment of inflammations such as inflammatory joint disease, for example, arthritis. In another aspect, the invention relates to pharmaceutical compositions and methods of use comprising the compounds of formula I.Type: GrantFiled: December 5, 1994Date of Patent: June 4, 1996Assignee: Hoffmann-La Roche Inc.Inventor: Hubert Maehr
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Patent number: 4218560Abstract: Esters of antibiotic X-5108 and of mocimycin, especially the acetic esters, exhibit activity as growth promotants in farm animals.Type: GrantFiled: November 24, 1978Date of Patent: August 19, 1980Assignee: Hoffmann-La Roche Inc.Inventor: Hubert Maehr
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Patent number: 4112216Abstract: The present invention relates to the conversion of the antibiotic mocimycin to the antibiotic known as X-5108 by treating mocimycin with a methylating agent after first protecting the 4-hydroxy functional group of the pyridone moiety, followed by subjecting the protecting group containing ester of X-5108 to mild basic hydrolysis whereby antibiotic X-5108 is obtained.Type: GrantFiled: December 10, 1976Date of Patent: September 5, 1978Assignee: Hoffmann-La Roche Inc.Inventor: Hubert Maehr
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Patent number: 4061542Abstract: The compound 2-methyl-L-arginine having useful antibiotic and anti-bacterial properties and its methods of preparation from a new species of Streptomyces sp. X-11837 or from 5-hydroxy-2-pentanone.Type: GrantFiled: March 8, 1976Date of Patent: December 6, 1977Assignee: Hoffmann-La Roche Inc.Inventors: Thomas Casimir Demny, Hubert Maehr