Patents by Inventor Hubertus J. A. Dielemans

Hubertus J. A. Dielemans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Boronic acid derivatives and synthesis thereof
    Patent number: 11286270
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, ?-lactamase inhibitors (BLIs).
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: March 29, 2022
    Assignee: Qpex Biopharma, Inc.
    Inventors: Scott J. Hecker, Serge Henri Boyer, Hubertus J. A. Dielemans, Angela Gonzalez de Castro, Andreas H. M. de Vries, Laurent Lefort
  • BORONIC ACID DERIVATIVES AND SYNTHESIS THEREOF
    Publication number: 20200407373
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, ?-lactamase inhibitors (BLIs).
    Type: Application
    Filed: October 10, 2018
    Publication date: December 31, 2020
    Inventors: Scott J. Hecker, Serge Henri Boyer, Hubertus J. A. Dielemans, Angela Gonzalez de Castro, Andreas H. M. de Vries, Laurent Lefort
  • Method for preparing an alpha-alkycinnamaldehyde
    Patent number: 5728892
    Abstract: The invention relates to a method for preparing an .alpha.-alkylcinnamaldehyde via aldol concensation of a benzaldehyde and an alkanal, with pyrrolidine being employed as a catalyst. The method is suitable, in particular, for preparing .alpha.-hexylcinnamaldehyde by aldol condensation of benzaldehyde and n-octanal, in particular for preparing .alpha.-hexylcinnamaldehyde of olfactory quality, since it was found that, in the method according to the invention, relatively little .alpha.-hexyldecenal, the aldol condensation product of n-octanal, is formed. Preferably, the aldol condensation is carried out without a solvent in the presence of an acid, and the alkanal is metered in over time to a mixture which contains pyrrolidine and benzaldehyde.
    Type: Grant
    Filed: November 6, 1996
    Date of Patent: March 17, 1998
    Assignee: DSM N.V.
    Inventors: Alie Kuiterman, Hubertus J. A. Dielemans, Richard Green, Anna M. C. F. Castelijns
  • Method for the preparation of 2-(2-cyanoethyl)-cyclopentanones
    Patent number: 5319125
    Abstract: The invention relates to a method for the preparation of a 2-(2-cyanoethyl)-cyclopentanone by reaction of a cyclopentanone which contains at least one .alpha.-H atom with an .alpha.,.beta.-unsaturated nitrile in the presence of a catalytic amount of pyrrolidine as catalyst and optionally also a catalytic amount of an acid compound. A high selectivity and a high catalyst activity are achieved with the method.
    Type: Grant
    Filed: March 30, 1993
    Date of Patent: June 7, 1994
    Assignee: DSM N.V.
    Inventors: Anna M. C. F. Castelijns, Hubertus J. A. Dielemans