Patents by Inventor Hugues Bienayme
Hugues Bienayme has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11730732Abstract: A pharmaceutical liquid suspension comprising: temozolomide or a salt thereof; at least one agent controlling the solid state of temozolomide in suspension; a pharmaceutically acceptable liquid vehicle; and optionally at least one acid in a quantity so that the pH of the composition is below 5; or a powder blend for reconstituting said suspension, is provided.Type: GrantFiled: December 13, 2019Date of Patent: August 22, 2023Assignees: Orphelia Pharma, Institut Gustave RoussyInventors: Maxime Annereau, Jérémy Bastid, Hugues Bienayme, François Lemare, Mathieu Schmitt, Lionel Tortolano, Samuel Abbou
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Publication number: 20200188390Abstract: The present invention concerns a pharmaceutical composition, advantageously a liquid suspension, comprising: a. temozolomide or a salt thereof; b. at least one agent controlling the solid state of temozolomide in suspension; c. a pharmaceutically acceptable liquid vehicle, advantageously water; d. optionally at least one acid in a quantity so that the pH of the composition is below 5; or a powder blend for reconstituting said suspension.Type: ApplicationFiled: December 13, 2019Publication date: June 18, 2020Applicants: Orphelia Pharma, Institut Gustave RoussyInventors: Maxime ANNEREAU, Jérémy BASTID, Hugues BIENAYME, François LEMARE, Mathieu SCHMITT, Lionel TORTOLANO
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Patent number: 8889711Abstract: The present invention concerns compounds of following general formula (I): (Formula I) and their pharmaceutically acceptable salts, their method of preparation and their uses, notably as anticancer agent.Type: GrantFiled: October 13, 2010Date of Patent: November 18, 2014Assignee: Pierre Fabre MedicamentInventors: Karim Bedjeguelal, Rémi Rabot, El Bachir Kaloun, Patrice Mayer, Arnaud Marchand, Nicolas Rahier, Philippe Schambel, Hugues Bienayme
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Publication number: 20130165693Abstract: The present invention relates to a new and competitive process for the preparation of 4-amino-5-hexenoic acid and intermediates thereof. The compound, and compositions containing the compound as an active ingredient, can be used for the treatment and/or prophylaxis of epilepsy and West syndrome.Type: ApplicationFiled: June 22, 2012Publication date: June 27, 2013Applicant: TARGEONInventors: Hugues BIENAYME, Florence Popowyce, Marc Lemaire, Marie-Christine Duclos
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Patent number: 8426437Abstract: The present invention relates to inhibitors of protein kinases of formula I: which can be used in the treatment of various diseases, notably cancer, inflammation or disorders of the central nervous system. It also relates to pharmaceutical compositions containing the compounds according to the invention and their use in therapy.Type: GrantFiled: June 30, 2006Date of Patent: April 23, 2013Assignee: Pierre Fabre MedicamentInventors: Hugues Bienayme, Antoine Dumoulin, Serge Grisoni, Bachir Kaloun El, Stephane Poigny, Remi Rabot, Rachid Rahali, Eric Tam, Pascaline Klein, Karim Bedjeguelal, Houcine Rahali
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Publication number: 20120245170Abstract: The present invention concerns compounds of following general formula (I): (Formula I) and their pharmaceutically acceptable salts, their method of preparation and their uses, notably as anticancer agent.Type: ApplicationFiled: October 13, 2010Publication date: September 27, 2012Applicant: Pierre Fabre MedicamentInventors: Karim Bedjeguelal, Rémi Rabot, El Bachir Kaloun, Patrice Mayer, Arnaud Marchand, Nicolas Rahier, Philippe Schambel, Hugues Bienayme
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Publication number: 20100063102Abstract: Use of a compound corresponding to formula (I) in which R represents hydrogen or a group chosen from alkyl, alkylene, alkylidyne, cycloalkyl, cycloalkylene, cycloalkylidyne and —CONH2 groups, and the —COR? and —COOR? groups, in which R? is chosen from alkyl, alkylene, alkylidyne, cycloalkyl, cycloalkylene and cycloalkylidyne groups, it being possible for said groups R and/or R? to be substituted and/or interrupted with -0-, —COO—, —OCO—, —NHCO— or —CONH— functions, or a pharmaceutically acceptable salt of said compound, for obtaining a medicament for use in the treatment of faecal incontinence.Type: ApplicationFiled: January 28, 2008Publication date: March 11, 2010Applicant: UROGENEInventors: Jacques Ferte, Hugues Bienayme, Francisco Carlos Perez Martinez
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Publication number: 20090048304Abstract: Crystal form of besipirdine chlorhydrate (Form I) corresponding to the Formula (A) below: the aforementioned form being characterized at least by one of the following physico-chemical properties: a) In FTIR, it displays at least the following absorption bands of the infrared spectrum: 778, 1198, 1121, but not the following absorption bands of the infrared spectrum: 3395, 1583, 732, the aforementioned bands being expressed in cm?1 at ±5 cm?1; b) In PXRD, it shows at least the following reflections, which are the most intense ones but whose intensity hereafter is given for information only: Formula (II) c) In DSC, it displays at least an endothermic peak at 187.3±2.0° C. using 5° C./min scanning conditions, and a fusion enthalpy ?H of 130.4±2.0 J/g. The invention also relates to the processes used for the preparation of form I as well as its applications in urology.Type: ApplicationFiled: February 20, 2007Publication date: February 19, 2009Applicant: UROGENEInventors: Hugues Bienayme, Jacques Ferte
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Publication number: 20090042876Abstract: The present invention relates to inhibitors of protein kinases of formula I: which can be used in the treatment of various diseases, notably cancer, inflammation or disorders of the central nervous system. It also relates to pharmaceutical compositions containing the compounds according to the invention and their use in therapy.Type: ApplicationFiled: June 30, 2006Publication date: February 12, 2009Applicant: Pierre Fabre MedicamentInventors: Hugues Bienayme, Antoine Dumoulin, Serge Grisoni, Bachir Kaloun El, Stephane Poigny, Remi Rabot, Rachid Rahali, Eric Tam, Pascaline Klein, Karim Bedjeguelal, Houcine Rahali
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Publication number: 20090036496Abstract: Use of a compound corresponding to formula (I): in which R represents hydrogen or a group chosen from alkyl, alkylene, alkylidyne, cycloalkyl, cycloalkylene, cycloalkylidyne and —CONH2 groups, and —COR? and —COOR? groups, where R? is chosen from alkyl, alkylene, alkylidyne, cycloalkyl, cycloalkylene and cycloalkylidyne groups, it being possible for said groups R and/or R? to be substituted and/or interrupted with —O—, —COO—, —OCO—, —NHCO— or —CONH— functions, or a pharmaceutically acceptable salt of said compound, for obtaining a medicinal product for use in the treatment of stress urinary incontinence and of mixed urinary incontinence.Type: ApplicationFiled: August 28, 2006Publication date: February 5, 2009Applicant: UROGENEInventors: Hugues Bienayme, Jacques Ferte
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Publication number: 20080293774Abstract: Use of a compound corresponding to formula (I), for obtaining a medicinal product for use in the treatment of the symptoms of bladder irritation.Type: ApplicationFiled: August 28, 2006Publication date: November 27, 2008Applicant: UROGENEInventors: Hugues Bienayme, Jacques Ferte
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Patent number: 5744617Abstract: A process for the preparation of substituted phenols, in particular, the condensation of phenols having one or more alkyl substituents with a butadiene derivative comprising at least six carbon atoms, in particular myrcene and/or .beta.-springene is disclosed. The cyclization, in the form of chromans, of the products obtained during this condensation and their hydrogenation in order to prepare vitamin E is also disclosed.Type: GrantFiled: May 10, 1996Date of Patent: April 28, 1998Assignee: Rhone-Poulenc Nutrition AnimaleInventors: Jean-Erick Ancel, Hugues Bienayme, Pierre Meilland
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Patent number: 5663459Abstract: The present invention relates to novel intermediates for the preparation of vitamin A and carotenoids corresponding to the formula (II): ##STR1## in which A represents a hydrogen or an alkyl, alkenyl or alkoxy group containing 1 to 4 carbon atoms, and X represents a carbon atom, and to a process for their preparation and their use, and further relates to compounds for preparing intermediates of formula (II) corresponding to the formula (III): ##STR2## in which R represents a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 10 carbon atoms, an alkylcarbonyl, alkenylcarbonyl, alkoxyalkyl or alkoxyalkenyl group in which the alkyl groups have 1 to 10 carbon atoms and the alkenyl groups have 2 to 10 carbon atoms, each of said groups being linear or branched and each being substituted or unsubstituted.Type: GrantFiled: June 7, 1995Date of Patent: September 2, 1997Assignee: Rhone-Poulenc Nutrition AnimaleInventors: Hugues Bienayme, Pierre Meilland
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Patent number: 5639919Abstract: The present invention relates to novel intermediates for the preparation of vitamin A and carotenoids, corresponding to the following formula (I): ##STR1## in which X is a carbon atom; n is equal to 1 or 2; R.sub.1, R.sub.2 and R.sub.3, which may be identical or different, each independently represent hydrogen, alkyl containing 1 to 4 carbon atoms, alkenyl containing 2 to 11 carbon atoms or aryl, each alkyl and alkenyl may be linear, branched or cyclic, or R.sub.1 and R.sub.2 can together with the carbon atom to which they are attached form a cycloaliphatic compound which is optionally substituted; and R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be identical or different, each independently represent hydrogen, alkyl containing 1 to 4 carbon atoms or alkenyl containing 2 to 10 carbon atoms, each alkyl or alkenyl being linear, or if containing sufficient numbers of carbon atoms, may also be branched or cyclic, or an aryl containing 6 to 10 carbon atoms, or any two of R.sub.4, R.sub.5, R.sub.6, R.Type: GrantFiled: June 7, 1995Date of Patent: June 17, 1997Assignee: Rhone-Poulenc Nutrition AnimaleInventor: Hugues Bienayme
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Patent number: 5637779Abstract: A process for the preparation of vitamin A which comprises condensing ethynyl-.beta.-ionol with the acetal of a C.sub.5 allylic halide in the presence of a catalytic amount of a copper-based catalyst and a base; hydrogenating the condensed compound; eliminating the hydroxyl functional group to obtain retinal; and correcting the retinal obtained.Type: GrantFiled: February 3, 1995Date of Patent: June 10, 1997Assignee: Rhone-Poulenc Nutrition AnimaleInventors: Jean-Erick Ancel, Hugues Bienayme
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Patent number: 5567852Abstract: The present invention relates to novel intermediates for the preparation of vitamin A and carotenoids corresponding to the formula (II): ##STR1## in which A represents a hydrogen or an alkyl, alkenyl or alkoxy group containing 1 to 4 carbon atoms, and X represents a carbon atom, and to a process for their preparation and their use, and further relates to compounds for preparing intermediates of formula (II) corresponding to the formula (III): ##STR2## in which R represents a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 10 carbon atoms, an alkylcarbonyl, alkenylcarbonyl, alkoxyalkyl or alkoxyalkenyl group in which the alkyl groups have 1 to 10 carbon atoms and the alkenyl groups have 2 to 10 carbon atoms, each of said groups being linear or branched and each being substituted or unsubstituted.Type: GrantFiled: October 7, 1994Date of Patent: October 22, 1996Assignee: Rhone-Poulenc Nutrition AnimaleInventors: Hugues Bienayme, Pierre Meilland
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Patent number: 5563297Abstract: The present invention relates to novel intermediates for the preparation of vitamin A and carotenoids, corresponding to the following formula (I): ##STR1## in which X is a carbon atom; n is equal to 1 or 2; R.sub.1, R.sub.2 and R.sub.3, which may be identical or different, each independently represent hydrogen, alkyl containing 1 to 4 carbon atoms, alkenyl containing 2 to 11 carbon atoms or aryl, each alkyl and alkenyl may be linear, branched or cyclic, or R.sub.1 and R.sub.2 can together with the carbon atom to which they are attached form a cycloaliphatic compound which is optionally substituted; and R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be identical or different, each independently represent hydrogen, alkyl containing 1 to 4 carbon atoms or alkenyl containing 2 to 10 carbon atoms, each alkyl or alkenyl being linear, or if containing sufficient numbers of carbon atoms, may also be branched or cyclic, or an aryl containing 6 to 10 carbon atoms, or any two of R.sub.4, R.sub.5, R.sub.6, R.Type: GrantFiled: October 7, 1994Date of Patent: October 8, 1996Assignee: Rhone-Poulenc Nutrition AnimaleInventor: Hugues Bienayme
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Patent number: 5169943Abstract: The invention concerns a chiral reaction medium for organic reactions and consists of concentrated aqueous solution of at least one carbohydrate selected from among the mono-, di- and tri-saccharides and their alkylglucosides of which the alkyl group comprises from 1 to 4 C atoms.Type: GrantFiled: December 14, 1990Date of Patent: December 8, 1992Assignee: Beghin-Say, S.A.Inventors: Andre Lubineau, Hugues Bienayme, Yves Queneau