Abstract: Novel N-substituted norcantharimide derivatives are disclosed herein. The novel N-substituted norcantharimide derivatives are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly for treating leukemia.

Abstract: Novel N-substituted norcantharimide derivatives are disclosed herein. The novel N-substituted norcantharimide derivatives are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly for treating leukemia.

Abstract: The present invention relates to a method of treating leukemia using rice prolamin, comprising administering a daily dose of isolated prolamin to a patient suffering from leukemia for a period of time from 5 days to 10 days. For the treatment application, the rice prolamin can stimulate human peripheral blood mononuclear cell (PBMC) to produce cytokines, such as tumor necrosis factor-alpha, to inhibit growth of and induce differentiation of human leukemia cells. The rice prolamin is gluten-free, thus will not trigger gastrointestinal allergic reaction, it also can decrease the tumor weight without changes in body weight and can inhibit the growth of peripheral blood leukocyte in leukemia mouse model.

Abstract: The present invention relates to a method of treating leukemia using rice prolamin, comprising administering a daily dose of isolated prolamin to a patient suffering from leukemia for a period of time from 5 days to 10 days. For the treatment application, the rice prolamin can stimulate human peripheral blood mononuclear cell (PBMC) to produce cytokines, such as tumor necrosis factor-alpha, to inhibit growth of and induce differentiation of human leukemia cells. The rice prolamin is gluten-free, thus will not trigger gastrointestinal allergic reaction, it also can decrease the tumor weight without changes in body weight and can inhibit the growth of peripheral blood leukocyte in leukemia mouse model.

Abstract: Novel Uses of small molecules, particularly, 6-methylsulfinylhexyl isothiocyanate and 6-methylsulfonylhexyl isothiocyanate, are disclosed herein. The two isothiocyanates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly drug-resistant cancer, in a patient.

Abstract: Novel Uses of small molecules, particularly, 6-methylsulfinylhexyl isothiocyanate and 6-methylsulfonylhexyl isothiocyanate, are disclosed herein. The two isothiocyanates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly drug-resistant cancer, in a patient.

Abstract: The present invention relates to a method of treating leukemia using rice prolamin, and a pharmaceutical composition for treating leukemia, comprising an effective amount of rice prolamin together with one or more pharmaceutically acceptable carriers or excipients. For the treatment application, the rice prolamin can stimulate human peripheral blood mononuclear cell (PBMC) to produce cytokines, such as tumor necrosis factor-alpha, to inhibit growth of and induce differentiation of human leukemia U937 cells. The rice prolamin is gluten-free, thus will not trigger gastrointestinal allergic reaction.

Abstract: A water valve apparatus includes a housing and a control valve stem. The housing has a spacer to divide the interior space and a base with a plurality of water outlets formed thereon. The spacer has a first opening. The base has a second opening corresponding to the first opening. The spacer and base are interposed by a displacement track. The displacement track has at least one first anchor zone and one second anchor zone. The valve control stem runs through the first opening and second opening, and has a water stopper located in the first opening and an anchor ring movably coupled thereon. The anchor ring has at least an anchor stub in the displacement track. The valve control stem is operable easily to allow users to determine water supply. No excessive contact with water faucets is needed. Thus the risk of bacteria contagion can be minimized.

Abstract: A water valve apparatus includes a housing and a control valve stem. The housing has a spacer to divide the interior space and a base with a plurality of water outlets formed thereon. The spacer has a first opening. The base has a second opening corresponding to the first opening. The spacer and base are interposed by a displacement track. The displacement track has at least one first anchor zone and one second anchor zone. The valve control stem runs through the first opening and second opening, and has a water stopper located in the first opening and an anchor ring movably coupled thereon. The anchor ring has at least an anchor stub in the displacement track. The valve control stem is operable easily to allow users to determine water supply. No excessive contact with water faucets is needed. Thus the risk of bacteria contagion can be minimized.

Abstract: Disclosed is a medical composition for inducing differentiation of leukemic cells, which can induce leukemic cells to differentiate into monocytes and macrophages, and block the abnormal proliferation of leukemic cells through a PKC-independent pathway. In addition, the medical composition cans also downregulate c-myc gene expression in the leukemic cells, and upnregulate c-fms, c-fos and c-jun gene. The medical composition comprises a compound represented by the general formula (I) shown below: wherein R1, R2, and R3 represent —H, a linear or branched alkyl group with 1 to 3 carbon atoms, and R4 represents —H or a benzyl group.

Abstract: A nutraceutical composition containing 0.01-99% by weight polysaccharides enriched from an extract of beans of Glycine max (L.) Merr. Also disclosed are a method of enriching polysaccharides from pulverized beans of Glycine max (L.) Merr.; a polysaccharide having a backbone of ?-(1,6)-linked glucose residues, and one or more galactose or mannose residues are bonded to the C-3 or C-4 position of one or more of the glucose residues by a (1,3)- or a (1,4)-linkage; and a method of treating a subject with such polysaccharides to increase blood cell counts.

Abstract: A nutraceutical composition containing 0.01-99% by weight polysaccharides enriched from an extract of beans of Glycine max (L.) Merr. Also disclosed are a method of enriching polysaccharides from pulverized beans of Glycine max (L.) Merr.; a polysaccharide having a backbone of ?-(1,6)-linked glucose residues, and one or more galactose or mannose residues are bonded to the C-3 or C-4 position of one or more of the glucose residues by a (1,3)- or a (1,4)-linkage; and a method of treating a subject with such polysaccharides to increase blood cell counts.

Abstract: A nutraceutical composition containing 0.01-99% by weight polysaccharides enriched from an extract of beans of Glycine max (L.) Merr. Also disclosed are a method of enriching polysaccharides from pulverized beans of Glycine max (L.) Merr.; a polysaccharide having a backbone of &agr;-(1,6)-linked glucose residues, and one or more galactose or mannose residues are bonded to the C-3 or C-4 position of one or more of the glucose residues by a (1,3)- or a (1,4)-linkage; and a method of treating a subject with such polysaccharides to increase blood cell counts.