Abstract: Systems and methods using a double-walled portable container with pressurized gaseous Xe-124 are used as a target for thermal neutron irradiation that generates Xe-125. The portable container is transferred, while submerged in the reactor pool, to a mobile radiation shield container, which are then removed from the reactor pool and connected to the production apparatus that provides handling and recovery functions while properly shielded to minimize radiation exposure. A rapid and efficient transfer of induced Xe-125 and remaining Xe-124 is then accomplished into a clean spiral trap container in which the Xe-125 radioactivity is converted to Iodine-125. After the decay period is completed, Xe-124 and remaining Xe-125 are recovered leaving I-125 deposited on the internal surface of the spiral trap. I-125 is then removed with appropriate solvents.