Patents by Inventor Hushan Yuan

Hushan Yuan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Synthesizing and Using Peg-Like Fluorochromes
    Publication number: 20150258217
    Abstract: Fluorescent compounds include near infrared fluorochromes that are covalently linked to polyethylene glycol (PEG). The compounds behave like PEG in biological systems. One fluorescent compound has the formula (I): wherein R1 is a fluorescent moiety having an absorption wavelength maxima in the range of 450 to 1500 nanometers, R2 is a non-reactive moiety, and n is an integer. Another fluorescent compound has the formula (II): wherein R1 is a fluorescent moiety having an absorption wavelength maxima in the range of 450 to 1500 nanometers, R2 is a non-reactive moiety, R3 is a scaffold including an amino acid group, and n is an integer. The scaffold can be attached to a chelate, protein, enzyme, peptide, antibody, or drug that can target a site in a subject.
    Type: Application
    Filed: September 19, 2013
    Publication date: September 17, 2015
    Inventors: Peter Caravan, Lee Josephson, Yanyan Guo, Hushan Yuan
  • VITAL FLUOROCHROME CONJUGATES AND METHODS OF USE
    Publication number: 20120121509
    Abstract: The present invention provides compositions and methods based on vital fluorochrome conjugates that are useful for imaging dying and dead cells.
    Type: Application
    Filed: June 4, 2010
    Publication date: May 17, 2012
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Lee Josephson, Elisabeth Garanger, Scott Hilderbrand, David Sosnovik, Hushan Yuan
  • Wortmannin conjugates and uses thereof
    Publication number: 20090324489
    Abstract: The invention features conjugates of wortmannin, and wortmannin derivatives, and their use as inhibitors of PI3-kinase activity in treating cancer, inflammatory diseases, and C. albicans infections.
    Type: Application
    Filed: August 31, 2006
    Publication date: December 31, 2009
    Inventors: Hushan Yuan, Ji Luo, Ralph Weissleder, Lewis Cantley, Lee Josephson