Abstract: A method and system improve the detection of abnormalities, such as lung nodules, in radiological images using digital image processing and artificial neural network techniques. The detection method and system use a nodule phantom for matching in order to enhance the efficiency in detection. The detection method and system use spherical parameters to characterize true nodules, thus enabling detection of the nodules in the mediastinum. The detection method and system use a multi-layer back-propagation neural network architecture not only for the classification of lung nodules but also for the integration of detection results from different classifiers. In addition, this method and system improve the detection efficiency by recommending the ranking of true nodules and several false positive nodules prior to the training of the neural network classifier. The method and system use image segmentation to remove regions outside the chest in order to reduce the false positives outside the chest region.

Abstract: A fuzzy logic based classification (FLBC) method for the automated discrimination of objects and the automated identification of nodules based on their features, a computer programmed to implement the method, and a storage medium which stores a program for implementing the method, wherein nodule (or, object) features are first normalized and then automatically selected. Based on the selected features, suspect nodules (or, objects) are pre-grouped and then subjected to the corresponding trained linear classifier to remove those false positive nodules or abnormal objects that are linearly separable. Finally, the remaining suspect nodules or objects are further subjected to a trained fuzzy classifier for removing those false positive nodules or abnormal objects that are not linearly separable.

Abstract: A divide-and-conquer (DAC) method and system improve the detection of abnormalities, like lung nodules, in radiological images via the use of zone-based digital image processing and artificial neural networks. The DAC method and system divide the lung zone into different zones in order to enhance the efficiency in detection. Different image enhancement techniques are used for each different zone to enhance nodule images, as are different zone-specific techniques for selecting suspected abnormalities, extracting image features corresponding to selected abnormalities, and classifying the abnormalities as either true or false abnormalities.