Patents by Inventor Hwan-You Chang
Hwan-You Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11712696Abstract: A drug screening platform simulating hyperthermic intraperitoneal chemotherapy including a dielectrophoresis system, a microfluidic chip and a heating system is disclosed. The dielectrophoresis system is used to provide a dielectrophoresis force. The microfluidic chip includes a cell culture array and observation module and a drug mixing module. The cell culture array and observation module are used to arrange the cells into a three-dimensional structure through the dielectrophoresis force to construct a three-dimensional tumor microenvironment. The drug mixing module is coupled to the cell culture array and observation module and used to automatically split and mix the inputted drugs and output the drug combinations into the cell culture array and observation module.Type: GrantFiled: August 5, 2021Date of Patent: August 1, 2023Assignee: NATIONAL TSING HUA UNIVERSITYInventors: Te-Yu Chao, Yu-Ching Tung, Mao-Chih Hsieh, Yu-Ting Tai, Bing-Ying Ho, Wei-Chia Chang, Sung-Yang Wei, Chang-Hung Hsieh, Chung-Cheng Chou, Jen-Tsan Chi, Long Hsu, Hwan-You Chang, Huang-Ming Philip Chen, Cheng-Hsien Liu
-
Patent number: 11609185Abstract: A portable ring-type fluorescence optical system for observing microfluidic channel and an operating method thereof are disclosed. The portable ring-type fluorescence optical system includes a photographic chip, a first polarizer, an objective lens, a ring-type fluorescent light source, a biological sample on a microfluidic chip, a second polarizer and a bottom illumination light source arranged in order from top to bottom. The ring-type fluorescent light source is used to generate a ring-type fluorescent light to the biological sample on the microfluidic chip. The objective lens is used to magnify a fluorescent image of the biological sample on the microfluidic chip to focus on the photographic chip. The first polarizer disposed under the photographic chip and the second polarizer disposed under the biological sample form a non-zero angle to each other to block reflected lights that the biological sample reflects the lights emitted by the bottom illumination light source.Type: GrantFiled: August 9, 2021Date of Patent: March 21, 2023Assignee: NATIONAL TSING HUA UNIVERSITYInventors: Sung-Yang Wei, Long Hsu, Hwan-You Chang, Huang-Ming Chen, Jen-Tsan Chi, Chung-Cheng Chou, Yuh-Cherng Lai, Hung-Yu Yeh, Ting-Chou Wei, Yun-Ting Yao, Cheng-Hsien Liu
-
Publication number: 20220401956Abstract: A drug screening platform simulating hyperthermic intraperitoneal chemotherapy including a dielectrophoresis system, a microfluidic chip and a heating system is disclosed. The dielectrophoresis system is used to provide a dielectrophoresis force. The microfluidic chip includes a cell culture array and observation module and a drug mixing module. The cell culture array and observation module are used to arrange the cells into a three-dimensional structure through the dielectrophoresis force to construct a three-dimensional tumor microenvironment. The drug mixing module is coupled to the cell culture array and observation module and used to automatically split and mix the inputted drugs and output the drug combinations into the cell culture array and observation module.Type: ApplicationFiled: August 5, 2021Publication date: December 22, 2022Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Te-Yu CHAO, Yu-Ching TUNG, Mao-Chih HSIEH, Yu-Ting TAI, Bing-Ying HO, Wei-Chia CHANG, Sung-Yang WEI, Chang-Hung HSIEH, Chung-Cheng CHOU, Jen-Tsan CHI, Long HSU, Hwan-You CHANG, Huang-Ming Philip CHEN, Cheng-Hsien LIU
-
Publication number: 20220364995Abstract: A portable ring-type fluorescence optical system for observing microfluidic channel and an operating method thereof are disclosed. The portable ring-type fluorescence optical system includes a photographic chip, a first polarizer, an objective lens, a ring-type fluorescent light source, a biological sample on a microfluidic chip, a second polarizer and a bottom illumination light source arranged in order from top to bottom. The ring-type fluorescent light source is used to generate a ring-type fluorescent light to the biological sample on the microfluidic chip. The objective lens is used to magnify a fluorescent image of the biological sample on the microfluidic chip to focus on the photographic chip. The first polarizer disposed under the photographic chip and the second polarizer disposed under the biological sample form a non-zero angle to each other to block reflected lights that the biological sample reflects the lights emitted by the bottom illumination light source.Type: ApplicationFiled: August 9, 2021Publication date: November 17, 2022Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Sung-Yang WEI, Long HSU, Hwan-You CHANG, Huang-Ming CHEN, Jen-Tsan CHI, Chung-Cheng CHOU, Yuh-Cherng LAI, Hung-Yu YEH, Ting-Chou WEI, Yun-Ting YAO, Cheng-Hsien LIU
-
Publication number: 20170199188Abstract: The present invention is to provide a method of performing electropolymerized electrochemically active poly-films as a current signal to detect bacteremia. The method comprises conjugating an electrochemical redox-active molecular monomer and a specific antibody with a gold nanoparticle to form a modified gold nanoparticle, and the modified gold nanoparticles are conjugated to the surface of bacteria via a specific antibody to form an electrochemically active poly-film by electropolymerization. When applying a voltage, a redox-active current signal of the electropolymerized electrochemically active poly-films can be detected by a usual electrochemical detection system typically in the range between nA and mA.Type: ApplicationFiled: May 24, 2016Publication date: July 13, 2017Inventors: Fan-Gang Tseng, Jen-Kuei Wu, Hwan-You Chang, Pen-Cheng Wang
-
Publication number: 20150177229Abstract: A cell mobility characteristics sensing apparatus including a laser light source, a light sensor, an analyzing chip, and a display is disclosed. The laser light source emits laser beams to a cell sample. The light sensor senses scattered laser beams formed by the cell sample scattering the laser beams at a plurality of time points to obtain a plurality of laser scattering patterns corresponding to the plurality of time points respectively. The analyzing chip obtains a laser scattering pattern fluctuations information of the plurality of laser scattering patterns varied with the plurality of time points to estimate the mobility characteristics of the cells in the cell sample. The display shows the mobility characteristics of the cells in the cell sample estimated by the analyzing chip.Type: ApplicationFiled: December 24, 2014Publication date: June 25, 2015Inventors: Long HSU, William WANG, Sheng-Hsiang LI, Chung-Hao LU, Cheng-Hsien LIU, Yuh-Shyong YANG, Hwan-You CHANG, Sung-Yang WEI, Chung-Cheng CHOU
-
Publication number: 20140034499Abstract: A microfluidic control apparatus operating method is disclosed. The microfluidic control apparatus operating method is applied in a microfluidic control apparatus, and the microfluidic control apparatus includes a photoconductive material layer and a flow passage. The microfluidic control apparatus operating method includes steps of (a) when a light with a specific optical pattern is emitted toward the photoconductive material layer, at least three virtual electrodes being formed on the photoconductive material layer according to the specific optical pattern; (b) when the specific optical pattern changes, the at least three virtual electrodes also changing to generate an electro-osmotic force to control a moving state of a microfluid in the flow passage.Type: ApplicationFiled: October 7, 2013Publication date: February 6, 2014Applicant: CRYSTALVUE MEDICAL CORPORATIONInventors: Cheng-Hsien LIU, William WANG, Long HSU, Yuh-Shyong YANG, Hwan-You CHANG, Shih-Mo YANG, Chung-Cheng CHOU
-
Publication number: 20120043209Abstract: A microfluidic control apparatus and operating method thereof. The microfluidic control apparatus includes a photoconductive material layer and a flow passage. When a light with a specific optical pattern is emitted toward the photoconductive material layer, at least three virtual electrodes are formed on the photoconductive material layer according to the specific optical pattern. The at least three virtual electrodes include a first virtual electrode, a second virtual electrode and a third virtual electrode disposed beside the first virtual electrode. There is a specific proportion among a distance between first virtual electrode and third virtual electrode, a width of first virtual electrode, a distance between first virtual electrode and second virtual electrode, and a width of second virtual electrode. When the specific optical pattern changes, the at least three virtual electrodes also change to generate an electro-osmotic force to control the moving state of a microfluid in a flow passage.Type: ApplicationFiled: August 18, 2011Publication date: February 23, 2012Inventors: Cheng-Hsien Liu, William Wang, Long Hsu, Yuh-Shyong Yang, Hwan-You Chang, Shih-Mo Yang, Chung-Cheng Chou
-
Publication number: 20120034635Abstract: A method for amplifying adenosine triphosphate is provided, including mixing adenosine triphosphate sulfurylase, adenosine 5? phosphosulfate, adenylate kinase, uridine triphosphate, acetate kinase, acetyl phosphate, luciferin and luciferase in the presence of ATP to form a mixture, and reacting the mixture to amplify ATP. A method and reagent for detecting a concentration of microorganisms are also provided.Type: ApplicationFiled: November 26, 2010Publication date: February 9, 2012Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Ching-Yi Hsu, Meng-Shun Huang, Hwan-You Chang, Hui-Ju Lee, Ming-Rong Ho
-
Publication number: 20090191616Abstract: A biosensor structure and a method for fabricating the same are described. The biosensor structure for detecting at least a single cell includes a substrate with an insulating surface, a conductive layer and a plurality of capture molecules. The conductive layer is disposed on the substrate, and has a first pattern and a second pattern separated from each other. The first pattern includes a plurality of first finger configurations, and the second pattern includes a plurality of second finger configurations, so as to form interdigitated array. The capture molecules are immobilized on the conductive layer, such that the cell that is bound specifically to the capture molecules on two adjacent first and second finger configurations is detected. The biosensor structure is feasible for real-time (<3 min), specific, and quantitative targeted cell detection down to a single cell.Type: ApplicationFiled: August 27, 2008Publication date: July 30, 2009Applicant: National Tsing Hua UniversityInventors: Yi-Chun Lu, Tri-Rung Yew, Hwan-You Chang, Ya-Shuan Chuang
-
Publication number: 20080108121Abstract: A method of arranging cells comprises: (a) applying a voltage to two electrodes so as to allow a plurality of cells suspended in a dielectrophoresis-manipulating buffer (DEP-manipulating buffer) to be driven to be arranged into a pattern; (b) replacing the DEP-manipulating buffer with a solution comprising calcium ion and magnesium ion which helps the patterned cells adhere to the substrate; and (c) replacing the solution comprising calcium ion and magnesium ion with a medium so as to allow the patterned cells to grow on the substrate.Type: ApplicationFiled: May 3, 2007Publication date: May 8, 2008Applicant: BenQ CorporationInventors: Cheng-Hsien Liu, Hwan-You Chang, Long Hsu, Chen-Ta Ho, Ruei-Zeng Lin, Wai William Wang, Ta-Yuan Lee, Chung-Cheng Chou, Chen Peng, Fung-Hsu Wu