Patents by Inventor Hyun Sook Lee
Hyun Sook Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8257953Abstract: The present invention relates to a hyperthermophilic DNA polymerase and a preparation method thereof. The invention provides a novel hyperthermophilic DNA polymerase isolated from a Thermococcus sp. strain, a functional equivalent thereof, a protein having the amino acid sequence thereof, and a preparation method thereof. The DNA polymerase according to the invention is a DNA polymerase, which is hyperthermophilic and has an elongation ability and fidelity higher than those of prior commercial DNA polymerases. Thus, the DNA polymerase according to the invention will be useful in precision analysis, precision diagnosis, identification and the like, which require accurate PCR.Type: GrantFiled: October 2, 2006Date of Patent: September 4, 2012Assignee: Korean Ocean Research & Development InstituteInventors: Jung Hyun Lee, Suk Tae Kwon, Sung Gyun Kang, Sang Jin Kim, Jung Ho Hyun, Kae Kyoung Kwon, Yun Jae Kim, Hyun Sook Lee, Seung Seob Bae, Ki Hoon Nam, Jae Kyu Lim, Jung Ho Jeon, Sung Hyun Yang
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Patent number: 8232070Abstract: This invention relates to a gene encoding ?Np63? and screening methods of anticancer-drugs thereof, more specifically a gene encoding ?Np63? and a protein which is transported from nucleus to cytoplasm by contacting with potential anti-cancer-drugs in an epithelial cell carcinoma, a recombinant vector comprising said gene and reporter genes, and carcinoma cells comprising said vector. Also, This invention relates to high throughput screening methods of anticancer-drug comprising identifying the transportation of ?Np63? protein from nucleus to cytoplasm by contacting with potential anticancer-drug in a carcinoma cell.Type: GrantFiled: March 30, 2007Date of Patent: July 31, 2012Assignee: Seoul National University Industry FoundationInventors: Hyun Sook Lee, Jung Hwa Lee
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Publication number: 20120162199Abstract: In an apparatus and a method for displaying a three-dimensional augmented reality, an apparatus to display a three-dimensional augmented reality includes an object area detecting unit to detect a first object area of a left image frame of a three-dimensional image and a second object area of a right image frame of the three-dimensional image based on a selected object of the three-dimensional image; and a frame adjusting unit to adjust the left image frame and the right image frame to change a three-dimensional effect of the selected object.Type: ApplicationFiled: September 2, 2011Publication date: June 28, 2012Applicant: PANTECH CO., LTD.Inventors: KEUN YOUNG LEE, KYUN YOUNG BAEK, JUNG-AH YANG, SANG-MI LEE, HYUN-SOOK LEE
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Publication number: 20110020896Abstract: The present invention relates to mutant DNA polymerases, their genes and their uses. More specifically, the present invention relates to mutant DNA polymerases which are originally isolated from Thermococcus sp NA1. strain and produced by site-specific mutagenesis, their amino acid sequences, genes encoding said mutant DNA polymerases, their nucleic acids and PCR methods by using thereof. As mutant DNA polymerases according to the present invention have decreased proofreading activity and changed function of inosine sensing effectively compared to wild type DNA polymerase, PCR using primers with specific nucleic acids has made rapid progress. Therefore, the present invention is broadly applicable for PCR in various molecular genetic technologies.Type: ApplicationFiled: October 2, 2007Publication date: January 27, 2011Inventors: Jung Hyun Lee, Sung Gyun Kang, Sang Jin Kim, Kae Kyoung Kwon, Hyun Sook Lee, Yun Jae Kim, Seung Seob Bae, Jae Kyu Lim, Jung Ho Jeon, Yo Na Cho, Suk Tae Kwon
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Publication number: 20100311142Abstract: The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing the strains in specific culture conditions. Thus, the methods of the invention have advantages in that they are more economic and efficient than existing hydrogen production methods and can produce hydrogen even at high temperature.Type: ApplicationFiled: September 7, 2009Publication date: December 9, 2010Applicant: KOREA OCEAN RESEARCH & DEVELOPMENT INSTITUTEInventors: Jung Hyun Lee, Sung Gyun Kang, Hyun Sook Lee, Sang Jin Kim, Kae Kyoung Kwon, Sun Shin Cha, Jung Ho Jeon, Yona Cho, Yun Jae Kim, Seung Seop Bae, Jae Kyu Lim, In Soon Jeong
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Publication number: 20100297706Abstract: The present invention relates to mutant DNA polymerases and their genes isolated from Thermococcus sp. More specifically, the present invention relates to mutant DNA polymerases which are originally isolated from Thermococcus sp NA1. strain and produced by site-specific mutagenesis, their amino acid sequences, genes encoding said mutant DNA polymerases, their nucleic acids sequences, recombinant vectors containing said nucleic acids sequences, host cells transformed with thereof and methods for producing mutant DNA polymerase protein by using thereof. As mutant DNA polymerases according to the present invention have increased processivity by site-specific mutagenesis on exonuclease active site compared to wild type DNA polymerase, the present invention is broadly applicable for PCR in various molecular genetic technologies.Type: ApplicationFiled: October 2, 2007Publication date: November 25, 2010Applicant: KOREA OCEAN RESEARCH & DEVELOPMENT INSTITUTEInventors: Jung Hyun Lee, Sung Gyun Kang, Sang Jin Kim, Kae Kyoung Kwon, Hyun Sook Lee, Yun Jae Kim, Yong Gu Ryu, Seung Seob Bae, Jae Kyu Lim, Jung Ho Jeon, Yo Na Cho
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Publication number: 20100272689Abstract: The present invention relates to a protease having algicidal activity, a gene encoding the same and algicidal formulation comprising the same. The protease according to the present invention showed high algicidal activity. Therefore, the protease can be used treatment of red tide in marine region of red tide occurrence.Type: ApplicationFiled: April 25, 2008Publication date: October 28, 2010Applicant: KOREA OCEAN RESEARCH & DEVELOPMENT INSTITUTEInventors: Sang-Jin Kim, Sung-Gyun Kang, Kae-Kyoung Kwon, Jung-Hyun Lee, Hyun-Sook Lee, Ji-Hyun Kang, Jae-Hak Sohn
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Publication number: 20100179440Abstract: The present invention relates to a noninvasive medical pulsimeter sensor using a hall device. By forming a pulse-sensing part array with a hall device as a magnetic sensor, over the skin-contacting part which consists of a magnetic material, the present invention increases the integrity of sensors, enables to understand the spatial characteristics of the pulse which cannot be determined by the conventional pressure sensors, minimize the time for searching the pulse, and is applicable widely to portable pulsimeters and the likes.Type: ApplicationFiled: February 20, 2007Publication date: July 15, 2010Applicant: UNIMATEC CO. LTD.Inventors: Sang Suk Lee, Sang Dae Choi, Myoung Chone An, Young Kuen Choi, Ki Wang Kim, Dal Ho Park, Do Gwun Hwang, Soo Yong Ahn, Mi Sun Kim, Hyun Sook Lee, Hyeon Ho Kim
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Publication number: 20100105045Abstract: This invention relates to a gene encoding ?Np63? and screening methods of anticancer-drugs thereof, more specifically a gene encoding ?Np63? and a protein which is transported from nucleus to cytoplasm by contacting with potential anti-cancer-drugs in an epithelial cell carcinoma, a recombinant vector comprising said gene and reporter genes, and carcinoma cells comprising said vector. Also, This invention relates to high throughput screening methods of anticancer-drug comprising identifying the transportation of ?Np63? protein from nucleus to cytoplasm by contacting with potential anticancer-drug in a carcinoma cell.Type: ApplicationFiled: March 30, 2007Publication date: April 29, 2010Inventors: Hyun Sook Lee, Jung Hwa Lee
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Publication number: 20090148896Abstract: The present invention relates to a hyperthermophilic DNA polymerase and a preparation method thereof. The invention provides a novel hyperthermophilic DNA polymerase isolated from a Thermococcus sp. strain, a functional equivalent thereof, a protein having the amino acid sequence thereof, and a preparation method thereof. The DNA polymerase according to the invention is a DNA polymerase, which is hyperthermophilic and has an elongation ability and fidelity higher than those of prior commercial DNA polymerases. Thus, the DNA polymerase according to the invention will be useful in precision analysis, precision diagnosis, identification and the like, which require accurate PCR.Type: ApplicationFiled: October 2, 2006Publication date: June 11, 2009Applicant: Korea Ocean Research & Development InstituteInventors: Jung Hyun Lee, Suk Tae Kwon, Sung Gyun Kang, Sang Jin Kim, Jung Ho Hyun, Kae Kyoung Kwon, Yun Jae Kim, Hyun Sook Lee, Seung Seob Bae, Ki Hoon Nam, Jae Kyu Lim, Jung Ho Jeon, Sung Hyun Yang
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Patent number: 7403891Abstract: The present invention relates to an apparatus and method for recognizing biological named entity from biological literature based on united medical language system (UMLS). The apparatus and the method receives metathesaurus from the UMLS, constructs a concept name database, a single name database and a category keyterm database, which are language resources to be used recognize a named entity, receives each concept name stored in the concept name database, extracts features of each of the concept names by using data stored in the single name database and the category keyterm database, constructs a rule database by creating rules used to recognize the named entity and filtering the rules by using the extracted features, receives a biological literature, extracts nouns and noun phrases that are candidate named entities, applies the rules stored in the rule database to the nouns and the noun phrases, and recognizes the named entities.Type: GrantFiled: February 13, 2004Date of Patent: July 22, 2008Assignee: Electronics and Telecommunications Research InstituteInventors: Soo Jun Park, Tae Hyun Kim, Hyun Sook Lee, Hyun Chul Jang, Seon Hee Park
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Publication number: 20060136147Abstract: A biological relationship extraction system including a biological named entity substitution unit substituting a biological named entity in a biological document with a predetermined substitution name; a structure analyzing unit parsing the biological named entity in the biological document containing the substituted biological named entity; a relationship analyzing unit analyzing a relationship between biological named entities from the biological literature parsed by the structure analyzing unit and selecting relationship candidates; a relationship determining unit determining whether the relationship candidates delivered from the relationship analyzing unit are biologically meaningful and determining a relationship between biological named entities; and a biological named entity assignment storage unit storing the biological named entity and a substitution name corresponding to the biological named entity and providing a substitution name or a biological named entity.Type: ApplicationFiled: December 15, 2005Publication date: June 22, 2006Inventors: Hyun-Chul Jang, Hyun-Sook Lee, Jae-Soo Lim, Soo-Jun Park, Seon Park
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Publication number: 20050091081Abstract: The present invention relates to an apparatus and method for recognizing biological named entity from biological literature based on united medical language system (UMLS). The apparatus and the method receives metathesaurus from the UMLS, constructs a concept name database, a single name database and a category keyterm database, which are language resources to be used recognize a named entity, receives each concept name stored in the concept name database, extracts features of each of the concept names by using data stored in the single name database and the category keyterm database, constructs a rule database by creating rules used to recognize the named entity and filtering the rules by using the extracted features, receives a biological literature, extracts nouns and noun phrases that are candidate named entities, applies the rules stored in the rule database to the nouns and the noun phrases, and recognizes the named entities.Type: ApplicationFiled: February 13, 2004Publication date: April 28, 2005Inventors: Soo Jun Park, Tae Hyun Kim, Hyun Sook Lee, Hyun Chul Jang, Seon Hee Park
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Publication number: 20040168089Abstract: To access control without changing a presently used version of a system application protocol, an operator enters an ID and a password of the operator for user authentication, and, if the user authentication is successful, the operator will have access to an application layer of a system managed using either TCP/IP or UDP/IP. The application layer is adapted to be accessed using a security module to confirm whether or not an IP address of a terminal used by the operator is a preset IP address. In a network operating a version of a network management interface not equipped with a security function, the security deficiency of the system is alleviated by simply adding the security module without effecting a version upgrade process.Type: ApplicationFiled: February 13, 2004Publication date: August 26, 2004Inventor: Hyun-Sook Lee
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Patent number: 5635473Abstract: The present invention relates to a novel use of a biologically active protein, p53 as an inhibitor of hepatitis B virus(HBV) replication. The inhibitory role of p53 on HBV replication was assessed by the reduced levels of three different markers, i.e., HBsAg and HBc/eAg secreted into the medium, HBV DNA, and RNAs. Based on the above results, it was concluded that wild-type p53 specifically represses the activity of pregenomic/core promoter of HBV and inhibits the replication of HBV by down-regulation of the pregenomic/core promoter. Therefore, the present invention provides a novel use of protein p53 as a HBV replication inhibitor which can be developed into an agent for the treatment of acute/chronic hapatitis and prevention of liver cirrhosis and hepatocellular carcinoma(HCC) caused by HBV.Type: GrantFiled: April 24, 1995Date of Patent: June 3, 1997Assignee: Mogam Biotechnology Research InstituteInventors: Hyun-Sook Lee, Yung-Dae Yun, Hong-Mo Moon