Abstract: The present invention relates to a fusion protein comprising small heat shock protein, a cage protein formed thereby, and novel use thereof, more particularly, a fusion protein comprising a small heat shock protein, a recognition site of a protease, and a histidine polymer, wherein the recognition site and the histidine polymer are sequentially linked to a carboxyl terminal of the small heat shock protein, a cage protein formed thereby, and novel use thereof. The fusion protein of the present invention, and a cage protein formed by the self-assembly properties of the fusion protein are not cytotoxic, and emits a fluorescence signal of about 20 to about 50 times higher comparing to a single peptide for the conventional molecular imaging, per unit protein. Additionally, cell permeability is very excellent, thereby to be effectively used as a biosensor or a bioactive material carrier.

Abstract: Recombinant proteins for siRNA delivery and a composition including same. These recombinant proteins include a p19 RNA binding protein and a target oriented peptide and can secure the stability of siRNAs from external attacks such as various degradation enzymes, have selective binding affinity to cancer cells by virtue of target-oriented peptides having various cancer cells as their target, and silence target genes by effectively delivering the siRNAs to cells and biological tissues by the release of the siRNAs to the cytoplasms after the cell penetration thereof. Therefore, they are expected to be effectively employed as siRNA delivery vehicles for siRNA therapeutic agents, cell-based drug screening compositions and research.

Abstract: This invention relates to a recombinant protein for siRNA delivery and a composition comprising the same. The recombinant proteins for siRNA delivery of the invention can secure the stability of siRNAs from external attacks such as various degradation enzymes, have selective binding affinity to cancer cells by virtue of target-oriented peptides having various cancer cells as their target, and silence target genes by effectively delivering the siRNAs to cells and biological tissues by the release of the siRNAs to the cytoplasms after the cell penetration thereof. Therefore, they are expected to be effectively employed as siRNA delivery vehicles for siRNA therapeutic agents, cell-based drug screening compositions and research.

Abstract: The present invention relates to recombinant albumins fused with poly-cysteine peptide and methods for preparing the same, more precisely recombinant albumins in which cysteines that can be used for drug binding are amplified at N-terminal and C-terminal of the albumin and methods for preparing the same. The recombinant albumin of the present invention demonstrates improved albumin-drug conjugation efficiency when it is used for drug delivery system, indicating that it can effectively deliver a large amount of drug to a target tissue. At the same time, the recombinant albumin of the present invention can be used as an excellent drug deliverer with reduced side effects, compared with the conventional albumin carriers, by regulating the amount of drug conjugated to each unit of albumin by regulating the number of cysteine fused thereto.

Abstract: The present invention relates to a fusion protein comprising small heat shock protein, a cage protein formed thereby, and novel use thereof, more particularly, a fusion protein comprising a small heat shock protein, a recognition site of a protease, and a histidine polymer, wherein the recognition site and the histidine polymer are sequentially linked to a carboxyl terminal of the small heat shock protein, a cage protein formed thereby, and novel use thereof. The fusion protein of the present invention, and a cage protein formed by the self-assembly properties of the fusion protein are not cytotoxic, and emits a fluorescence signal of about 20 to about 50 times higher comparing to a single peptide for the conventional molecular imaging, per unit protein. Additionally, cell permeability is very excellent, thereby to be effectively used as a biosensor or a bioactive material carrier.

Abstract: The present invention relates to a recombinant protein for siRNA delivery, which allows the efficient intracellular and in vivo delivery of siRNA. More particularly, the present invention relates to a recombinant protein that allows a siRNA binding protein to be located in the interior cavity of a capsid protein of HBV (Hepatitis B virus), in which siRNAs of interest bind to the siRNA binding protein to be encapsulated within the capsid shell, thereby providing stability against the external attack such as nucleases and achieving the efficient intracellular and in vivo delivery of siRNA by its release into the cytosolic space after cell uptake.

Abstract: The present invention relates to recombinant albumins fused with poly-cysteine peptide and methods for preparing the same, more precisely recombinant albumins in which cysteines that can be used for drug binding are amplified at N-terminal and C-terminal of the albumin and methods for preparing the same. The recombinant albumin of the present invention demonstrates improved albumin-drug conjugation efficiency when it is used for drug delivery system, indicating that it can effectively deliver a large amount of drug to a target tissue. At the same time, the recombinant albumin of the present invention can be used as an excellent drug deliverer with reduced side effects, compared with the conventional albumin carriers, by regulating the amount of drug conjugated to each unit of albumin by regulating the number of cysteine fused thereto.

Abstract: The present invention provides a plasmid for expressing a thioredoxin fusion protein comprising thioredoxin as a fusion partner, an E. coli cell transformed with the plasmid, and an efficient method for producing a target protein using the E. coli cell. The method according to the present invention can easily remove thioredoxin from thioredoxin fusion protein, so that can produce a target protein of interest in pure and large quantities in the field of medicine and bioengineering.

Abstract: The present invention relates to a frame panel having an improved reinforcing pattern. The frame panel includes a panel body having a front plate and a rear plate, which are integrally formed as a single body through a blowing process. The front plate has vertical groove patterns and horizontal groove patterns on the outside area except for the central area thereof, while the rear plate has vertical groove patterns and horizontal groove patterns on each of the central area and the outside area thereof, thus forming rectangular reinforcing groove patterns, with a diagonal groove pattern diagonally extending upwards from the lower end of a side of the rectangular reinforcing groove pattern provided on the outside area of the rear plate such that the diagonal groove pattern passes through the rectangular reinforcing groove pattern provided on the central area of the rear plate.

Abstract: The present invention relates to a frame panel having an improved reinforcing pattern. The frame panel includes a panel body having a front plate and a rear plate, which are integrally formed as a single body through a blowing process. The front plate has vertical groove patterns and horizontal groove patterns on the outside area except for the central area thereof, while the rear plate has vertical groove patterns and horizontal groove patterns on each of the central area and the outside area thereof, thus forming rectangular reinforcing groove patterns, with a diagonal groove pattern diagonally extending upwards from the lower end of a side of the rectangular reinforcing groove pattern provided on the outside area of the rear plate such that the diagonal groove pattern passes through the rectangular reinforcing groove pattern provided on the central area of the rear plate.

Abstract: The present invention relates to a plastic panel, and more particularly, to a plastic panel which comprises inner and outer panels wherein a bonding groove to be coated with an adhesive is formed on any one of the inner and outer panels. According to a preferred embodiment of the present invention, the bonding groove is formed on any one of the inner and outer panels, while a protrusion is formed on a bonding surface of the other of the inner and outer panels. Accordingly, since the bonding groove is bonded to the bonding surface of the inner or outer panel, the bonding groove can serve as a guide when the adhesive is applied. Thus, the adhesive can be applied at a uniform thickness to correct positions even though it is manually applied, and even an adhesive with certain fluidity can be prevented from leaking to the outside.