Patents by Inventor Hyungsoon Im
Hyungsoon Im has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230417667Abstract: Methods, systems, and apparatus, for a sensor-chip device for performing analysis on target substances. In one aspect, the sensor-chip assembly includes a chip body including a substrate, at least one metal layer formed on the substrate, and nanoholes formed in the metal layer, a base having an accommodating portion for accommodating the chip body, and a fixing member fixing the chip body accommodated in the accommodating portion by being coupled to the base.Type: ApplicationFiled: November 1, 2021Publication date: December 28, 2023Inventors: Hakho Lee, Hyungsoon Im, Nam Ho Bae, Seok Jae Lee, Kyoung Gyun Lee, Kwang Hee Kim, Kil Sun Roh
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Publication number: 20230326018Abstract: Disclosed is a method for examining cells including: acquiring image data of cells acquired from a region suspected to be a cancer lesion; analyzing the image data; determining whether an amount of the cells is sufficient based on the analyzed result; and determining whether cancer-probable cells are included in the cells based on the analyzed result and the determined result; wherein the cells are acquired through Fine Needle Aspiration (FNA).Type: ApplicationFiled: February 10, 2023Publication date: October 12, 2023Applicants: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY, THE GENERAL HOSPITAL CORPORATIONInventors: Moon Jae CHUNG, Hyungsoon IM
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Publication number: 20230160809Abstract: Systems, methods, and device can be used to detect target extracellular vesicles (“EVs”). One example of a method includes obtaining a nano-plasmonic array including nanostructures configured to amplify one or more specific wavelengths of electromagnetic radiation, flowing a liquid sample over the nano-plasmonic array, optionally labeling target EVs captured on the nano-plasmonic array with one or more reporter groups, projecting electromagnetic radiation onto the labeled target EVs captured on the nano-plasmonic array, and capturing an image of the target EVs by receiving electromagnetic radiation emitted, scattered, or reflected by the EVs or by reporter groups on the labeled target EVs.Type: ApplicationFiled: April 14, 2021Publication date: May 25, 2023Inventors: Hyungsoon Im, Ralph Weissleder
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Publication number: 20230123746Abstract: Systems, methods, and devices are described herein for detecting and/or monitoring target extracellular vesicles (“EVs”), e.g., to detect and/or monitor cancer treatment, such as breast cancer, in a subject. The methods can include obtaining a nano-plasmonic array including nanostructures configured to amplify one or more specific wavelengths of electromagnetic radiation, flowing a liquid sample over the nano-plasmonic array, optionally labeling target EVs captured on the nano-plasmonic array with one or more reporter groups, projecting electromagnetic radiation onto the labeled target EVs captured on the nano-plasmonic array, and capturing an image of the target EVs by receiving electromagnetic radiation emitted, scattered, or reflected by the labeled target EVs or by reporter groups on the labeled target EVs.Type: ApplicationFiled: October 14, 2022Publication date: April 20, 2023Inventors: Hyungsoon Im, Ralph Weissleder
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Patent number: 11525778Abstract: The disclosure features systems and methods for measuring and diagnosing target constituents bound to labeling particles in a sample. The systems include a radiation source, a sample holder, a detector configured to obtain one or more diffraction patterns of the sample each including information corresponding to optical properties of sample constituents, and an electronic processor configured to, for each of the one or more diffraction patterns: (a) analyze the diffraction pattern to obtain amplitude information and phase information corresponding to the sample constituents; (b) identify one or more particle-bound target sample constituents based on at least one of the amplitude information and the phase information; and (c) determine an amount of at least one of the particle-bound target sample constituents in the sample based on at least one of the amplitude information and the phase information.Type: GrantFiled: July 27, 2020Date of Patent: December 13, 2022Assignee: The General Hospital CorporationInventors: Ralph Weissleder, Hakho Lee, Hyungsoon Im, Cesar Castro
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Publication number: 20210080390Abstract: The disclosure features systems and methods for measuring and diagnosing target constituents bound to labeling particles in a sample. The systems include a radiation source, a sample holder, a detector configured to obtain one or more diffraction patterns of the sample each including information corresponding to optical properties of sample constituents, and an electronic processor configured to, for each of the one or more diffraction patterns: (a) analyze the diffraction pattern to obtain amplitude information and phase information corresponding to the sample constituents; (b) identify one or more particle-bound target sample constituents based on at least one of the amplitude information and the phase information; and (c) determine an amount of at least one of the particle-bound target sample constituents in the sample based on at least one of the amplitude information and the phase information.Type: ApplicationFiled: July 27, 2020Publication date: March 18, 2021Inventors: Ralph Weissleder, Hakho Lee, Hyungsoon Im, Cesar Castro
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Patent number: 10724948Abstract: The disclosure features systems and methods for measuring and diagnosing target constituents bound to labeling particles in a sample. The systems include a radiation source, a sample holder, a detector configured to obtain one or more diffraction patterns of the sample each including information corresponding to optical properties of sample constituents, and an electronic processor configured to, for each of the one or more diffraction patterns: (a) analyze the diffraction pattern to obtain amplitude information and phase information corresponding to the sample constituents; (b) identify one or more particle-bound target sample constituents based on at least one of the amplitude information and the phase information; and (c) determine an amount of at least one of the particle-bound target sample constituents in the sample based on at least one of the amplitude information and the phase information.Type: GrantFiled: July 2, 2018Date of Patent: July 28, 2020Assignee: The General Hospital CorporationInventors: Ralph Weissleder, Hakho Lee, Hyungsoon Im, Cesar Castro
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Patent number: 10557847Abstract: Disclosed herein are compositions and methods for exosome detection with high sensitivity by using a nano-plasmonic sensor. The nano-plasmonic sensor comprises a plurality of nanoapertures suitable for transmission measurements. The detection sensitivity is on the order of 104-fold higher than western blotting and 102-fold higher than enzyme-linked immunosorbent assay (ELISA). A portable imaging system is also disclosed, enabling rapid and high-throughput detection of exosomes. The nano-plasmonic sensor and imaging system can be useful in diagnostics.Type: GrantFiled: December 2, 2014Date of Patent: February 11, 2020Assignee: THE GENERAL HOSPITAL CORPORATIONInventors: Ralph Weissleder, Hakho Lee, Hyungsoon Im, Cesar Castro
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Publication number: 20190113451Abstract: The disclosure features systems and methods for measuring and diagnosing target constituents bound to labeling particles in a sample. The systems include a radiation source, a sample holder, a detector configured to obtain one or more diffraction patterns of the sample each including information corresponding to optical properties of sample constituents, and an electronic processor configured to, for each of the one or more diffraction patterns: (a) analyze the diffraction pattern to obtain amplitude information and phase information corresponding to the sample constituents; (b) identify one or more particle-bound target sample constituents based on at least one of the amplitude information and the phase information; and (c) determine an amount of at least one of the particle-bound target sample constituents in the sample based on at least one of the amplitude information and the phase information.Type: ApplicationFiled: July 2, 2018Publication date: April 18, 2019Inventors: Ralph Weissleder, Hakho Lee, Hyungsoon Im, Cesar Castro
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Patent number: 10012589Abstract: The disclosure features systems and methods for measuring and diagnosing target constituents bound to labeling particles in a sample. The systems include a radiation source, a sample holder, a detector configured to obtain one or more diffraction patterns of the sample each including information corresponding to optical properties of sample constituents, and an electronic processor configured to, for each of the one or more diffraction patterns: (a) analyze the diffraction pattern to obtain amplitude information and phase information corresponding to the sample constituents; (b) identify one or more particle-bound target sample constituents based on at least one of the amplitude information and the phase information; and (c) determine an amount of at least one of the particle-bound target sample constituents in the sample based on at least one of the amplitude information and the phase information.Type: GrantFiled: August 18, 2014Date of Patent: July 3, 2018Assignee: The General Hospital CorporationInventors: Ralph Weissleder, Hakho Lee, Hyungsoon Im, Cesar Castro
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Publication number: 20160334398Abstract: Disclosed herein are compositions and methods for exosome detection with high sensitivity by using a nano-plasmonic sensor. The nano-plasmonic sensor comprises a plurality of nanoapertures suitable for transmission measurements. The detection sensitivity is on the order of 104-fold higher than western blotting and 102-fold higher than enzyme-linked immunosorbent assay (ELISA). A portable imaging system is also disclosed, enabling rapid and high-throughput detection of exosomes. The nano-plasmonic sensor and imaging system can be useful in diagnostics.Type: ApplicationFiled: December 2, 2014Publication date: November 17, 2016Inventors: Ralph WEISSLEDER, Hakho LEE, Hyungsoon IM, Cesar CASTRO
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Publication number: 20160202163Abstract: The disclosure features systems and methods for measuring and diagnosing target constituents bound to labeling particles in a sample. The systems include a radiation source, a sample holder, a detector configured to obtain one or more diffraction patterns of the sample each including information corresponding to optical properties of sample constituents, and an electronic processor configured to, for each of the one or more diffraction patterns: (a) analyze the diffraction pattern to obtain amplitude information and phase information corresponding to the sample constituents; (b) identify one or more particle-bound target sample constituents based on at least one of the amplitude information and the phase information; and (c) determine an amount of at least one of the particle-bound target sample constituents in the sample based on at least one of the amplitude information and the phase information.Type: ApplicationFiled: August 18, 2014Publication date: July 14, 2016Inventors: Ralph Weissleder, Hakho Lee, Hyungsoon Im, Cesar Castro
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Patent number: 7927887Abstract: The present invention relates to a Field-Effect Transistor (FET) and, more particularly, to a Dielectric-Modulated Field-Effect Transistor (DMFET) and a method of fabricating the same. A DMFET according to an embodiment of the present invention comprises a substrate in which a source and a drain are formed, wherein the source and the drain are spaced apart from each other, a gate formed on a region between the source and the drain, of the substrate, wherein at least part of the gate is spaced apart from the substrate, biomolecules formed below a region spaced apart from the substrate, of the gate, and a linker for combining the gate and the biomolecules.Type: GrantFiled: January 15, 2008Date of Patent: April 19, 2011Assignee: Korea Advanced Institute Of Science And TechnologyInventors: Yang-Kyu Choi, Hyungsoon Im, Bonsang Gu
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Publication number: 20080283939Abstract: The present invention relates to a Field-Effect Transistor (FET) and, more particularly, to a Dielectric-Modulated Field-Effect Transistor (DMFET) and a method of fabricating the same. A DMFET according to an embodiment of the present invention comprises a substrate in which a source and a drain are formed, wherein the source and the drain are spaced apart from each other, a gate formed on a region between the source and the drain, of the substrate, wherein at least part of the gate is spaced apart from the substrate, biomolecules formed below a region spaced apart from the substrate, of the gate, and a linker for combining the gate and the biomolecules.Type: ApplicationFiled: January 15, 2008Publication date: November 20, 2008Inventors: Yang-Kyu Choi, Hyungsoon Im, Bonsang Gu