Patents by Inventor Hywel Bowden Jones
Hywel Bowden Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11739371Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes. The invention also relates to manufacturing and using molecular arrays and analytical approaches based on single molecule detection techniques.Type: GrantFiled: February 18, 2016Date of Patent: August 29, 2023Assignee: Invitae CorporationInventors: Patrick James Collins, Adrian Nielsen Fehr, Jill Lyndon Herschleb, Hywel Bowden Jones
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Publication number: 20220340958Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: ApplicationFiled: May 9, 2022Publication date: October 27, 2022Applicant: Invitae CorporationInventors: Adrian Nielsen Fehr, Patrick Kames Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Publication number: 20220298561Abstract: A method for quantifying labels on a substrate is performed by an electronic device with one or more processors and memory. The method includes obtaining digital data corresponding to a multi-dimensional measurement over the substrate; identifying a first set of sub-portions of the digital data; and, for a respective sub-portion of the first set of sub-portions of the digital data: increasing a quantity of labels, and subtracting a reference signal distribution from the respective sub-portion to obtain subtracted sub-portion data. The method also includes obtaining subtracted digital data. The subtracted digital data includes the subtracted sub-portion data for the respective sub-portion. The method further includes identifying a second set of one or more sub-portions of the subtracted digital data; and, for a respective sub-portion of the second set of one or more sub-portions of the subtracted digital data, increasing a quantity of labels.Type: ApplicationFiled: January 14, 2022Publication date: September 22, 2022Applicant: Invitae CorporationInventors: Hywel Bowden Jones, Andrea Lynn McEvoy
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Patent number: 11326204Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: GrantFiled: April 7, 2020Date of Patent: May 10, 2022Assignee: Invitae CorporationInventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Patent number: 11254973Abstract: A method for quantifying labels on a substrate is performed by an electronic device with one or more processors and memory. The method includes obtaining digital data corresponding to a multi-dimensional measurement over the substrate; identifying a first set of sub-portions of the digital data; and, for a respective sub-portion of the first set of sub-portions of the digital data: increasing a quantity of labels, and subtracting a reference signal distribution from the respective sub-portion to obtain subtracted sub-portion data. The method also includes obtaining subtracted digital data. The subtracted digital data includes the subtracted sub-portion data for the respective sub-portion. The method further includes identifying a second set of one or more sub-portions of the subtracted digital data; and, for a respective sub-portion of the second set of one or more sub-portions of the subtracted digital data, increasing a quantity of labels.Type: GrantFiled: September 1, 2017Date of Patent: February 22, 2022Assignee: Invitae CorporationInventors: Hywel Bowden Jones, Andrea Lynn McEvoy
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Publication number: 20200325528Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: ApplicationFiled: April 7, 2020Publication date: October 15, 2020Applicant: Singular Bio, Inc.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Patent number: 10626450Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: GrantFiled: August 11, 2017Date of Patent: April 21, 2020Assignee: Singular Bio, Inc.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Publication number: 20190284552Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes. The invention also relates to manufacturing and using arrays and analytical approaches based on single molecule detection techniques.Type: ApplicationFiled: May 26, 2017Publication date: September 19, 2019Applicant: Singular Bio, Inc.Inventors: Patrick James Collins, Hywel Bowden Jones
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Publication number: 20190241940Abstract: A method for quantifying labels on a substrate is performed by an electronic device with one or more processors and memory. The method includes obtaining digital data corresponding to a multi-dimensional measurement over the substrate; identifying a first set of sub-portions of the digital data; and, for a respective sub-portion of the first set of sub-portions of the digital data: increasing a quantity of labels, and subtracting a reference signal distribution from the respective sub-portion to obtain subtracted sub-portion data. The method also includes obtaining subtracted digital data. The subtracted digital data includes the subtracted sub-portion data for the respective sub-portion. The method further includes identifying a second set of one or more sub-portions of the subtracted digital data; and, for a respective sub-portion of the second set of one or more sub-portions of the subtracted digital data, increasing a quantity of labels.Type: ApplicationFiled: September 1, 2017Publication date: August 8, 2019Applicant: Singular Bio, Inc.Inventors: Hywel Bowden Jones, Andrea Lynn McEvoy
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Publication number: 20180179586Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: ApplicationFiled: August 11, 2017Publication date: June 28, 2018Applicant: Singular Bio, Inc.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Publication number: 20180051331Abstract: The invention includes methods for optimally designing probes and analyzing data from sequence-byhybridization and related methods of stretched molecules or other experimental approaches that provide local information. An exemplary method of analyzing a nucleic acid sample may comprise: selecting a group of one or more labeled oligonucleotide probe(s), contacting at least one of the group of the labeled oligonucleotide probe(s) to at least one nucleic acid molecule(s) from the nucleic acid sample, wherein the nucleic acid molecule(s) is stretched, and correlating one or more point(s) of contact to a structural characteristic of the nucleic acid sample. In some embodiments, the nucleic acid molecule(s) is deoxyribonucleic acid (DNA) and/or the method of contacting is hybridization or ligation.Type: ApplicationFiled: April 28, 2017Publication date: February 22, 2018Applicant: Singular Bio, Inc.Inventor: Hywel Bowden Jones
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Publication number: 20180023138Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject. The invention further relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: ApplicationFiled: October 31, 2015Publication date: January 25, 2018Applicant: Singular Bio, Inc.Inventors: Patrick James Collins, Hywel Bowden Jones, Alexandria Hui Wang
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Publication number: 20180023124Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes. The invention also relates to manufacturing and using molecular arrays and analytical approaches based on single molecule detection techniques.Type: ApplicationFiled: February 18, 2016Publication date: January 25, 2018Applicant: Singular Bio, Inc.Inventors: Patrick James Collins, Adrian Nielsen Fehr, Jill Lyndon Herschleb, Hywel Bowden Jones
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Patent number: 9758814Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: GrantFiled: November 23, 2015Date of Patent: September 12, 2017Assignee: Singular Bio, Inc.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Publication number: 20160076087Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: ApplicationFiled: November 23, 2015Publication date: March 17, 2016Applicant: Singular Bio, Inc.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Patent number: 9212394Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: GrantFiled: January 22, 2015Date of Patent: December 15, 2015Assignee: Singular Bio, Inc.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Publication number: 20150167077Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: ApplicationFiled: January 22, 2015Publication date: June 18, 2015Applicant: SINGULAR BIO INC.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Publication number: 20150111205Abstract: The invention includes methods for optimally designing probes and analyzing data from sequence-by-hybridization and related methods of stretched molecules or other experimental approaches that provide local information.Type: ApplicationFiled: January 17, 2013Publication date: April 23, 2015Applicant: SINGULAR BIO INC.Inventor: Hywel Bowden Jones
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Publication number: 20090130660Abstract: Association of Type 2 diabetes with single nucleotide polymorphisms and haplotypes are disclosed. Also disclosed are diagnostic applications in identifying those who have Type 2 diabetes or are at risk of developing Type 2 diabetes, and discovery of therapeutic agents and methods of treatment.Type: ApplicationFiled: December 5, 2005Publication date: May 21, 2009Inventors: Malek Faham, Soren Germer, Hywel Bowden Jones, Delphine Lagarde, Mitchell Lee Martin, Martin Emilio Moorhead, Erik Roy Rasmussen, Brian Kent Rhees, James Andrew Rosinski