Patents by Inventor Iacob Mathiesen
Iacob Mathiesen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230190570Abstract: A composition, method and related systems for treating and/or preventing spasticity in a patient using negative pressure therapy. The negative pressure therapy may include intermittent application of negative pressure to a limb or portion of a body, such as alternating between periods of negative pressure and ambient pressure. The negative pressure therapy may be applied on a regular basis for a predetermined period, such that an effective amount of negative pressure for treating spasticity and other symptoms of neurogenerative diseases is administered. The negative pressure therapy may be applied to cause intermittent activation of the venous arterial reflex in the body for a sustained period, such that symptoms of neurogenerative diseases are alleviated or prevented.Type: ApplicationFiled: June 22, 2021Publication date: June 22, 2023Inventors: Iacob MATHIESEN, Laura Anne INMAN
-
Publication number: 20230008306Abstract: An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising: a hollow needle; and fluid delivery means, wherein the apparatus is adapted to actuate the fluid delivery means in use so as to automatically inject fluid into body tissue during insertion of the needle into the said body tissue.Type: ApplicationFiled: September 19, 2022Publication date: January 12, 2023Inventors: Iacob Mathiesen, Torunn E. Tjelle, Knut Arvid Sorensen Rekdahl, Bjorn David-Andersen
-
Publication number: 20230001190Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.Type: ApplicationFiled: April 29, 2022Publication date: January 5, 2023Inventors: Rune KJEKEN, Iacob MATHIESEN, Torunn Elisabeth TJELLE, George MCHUGH
-
Patent number: 11471675Abstract: An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising: a hollow needle; and fluid delivery means, wherein the apparatus is adapted to actuate the fluid delivery means in use so as to automatically inject fluid into body tissue during insertion of the needle into the said body tissue.Type: GrantFiled: August 5, 2019Date of Patent: October 18, 2022Assignee: Inovio Pharmaceuticals, Inc.Inventors: Iacob Mathiesen, Torunn E. Tjelle, Knut Arvid Sorensen Rekdahl, Bjorn David-Andersen
-
Patent number: 11331479Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.Type: GrantFiled: July 9, 2019Date of Patent: May 17, 2022Assignee: Inovio Pharmaceuticals, Inc.Inventors: Rune Kjeken, Iacob Mathiesen, Elisabeth Torunn Tjelle, George McHugh
-
Patent number: 11259985Abstract: A pressure therapy device includes a pressure chamber, an inflatable padding, a seal, and a positioning mechanism. The pressure chamber has an opening arranged for admitting the inflatable padding and a limb of a user. The inflatable padding is inflatable to enclose and fix the limb in position. The seal covers the opening, including the inflatable padding and the limb to seal the pressure chamber from ambient atmospheric pressure. A pump unit is provided to generate a non-atmospheric pressure within the pressure chamber and includes a first valve system and a piston with safety release features for preventing unsafe pressure levels.Type: GrantFiled: October 1, 2018Date of Patent: March 1, 2022Assignee: OTIVIO ASInventors: Jonas Elderstiern, Hannes Ulvegard, Ronny Brakhya, Robert Axelsson, Iacob Mathiesen, Arnar Kristjansson
-
Publication number: 20210393472Abstract: A method and related systems for treating and/or preventing spasticity in a patient using negative pressure therapy. The negative pressure therapy may include intermittent application of negative pressure to a limb or portion of a body, such as alternating between periods of negative pressure and ambient pressure. The negative pressure therapy may be applied on a regular basis for a predetermined period, such that an effective amount of negative pressure for treating spasticity and other symptoms of neurogenerative diseases is administered. The negative pressure therapy may be applied to cause intermittent activation of the venous arterial reflex in the body for a sustained period, such that symptoms of neurogenerative diseases are alleviated or prevented.Type: ApplicationFiled: June 22, 2021Publication date: December 23, 2021Inventors: Iacob MATHIESEN, Laura Anne INMAN
-
Patent number: 11110021Abstract: A pressure therapy device includes a pressure chamber, an inflatable padding, a seal, and a positioning mechanism. The pressure chamber has an opening arranged for admitting the inflatable padding and a limb of a user. The inflatable padding is inflatable to enclose and fix the limb in position. The seal covers the opening, including the inflatable padding and the limb to seal the pressure chamber from ambient atmospheric pressure. A pump unit is provided to generate a non-atmospheric pressure within the pressure chamber and includes a first valve system and a piston with safety release features for preventing unsafe pressure levels.Type: GrantFiled: October 1, 2018Date of Patent: September 7, 2021Assignee: OTIVIO ASInventors: Juho Laasanen, Sanna Tuononen, Petri Rantanen, Joachim Rasmussen, Andreas Erlandsen, Jakob Pettersen, Marius Andresen, Iacob Mathiesen, Arnar Kristjansson, Jonas Elderstiern, Hannes Ulvegard, Ronny Brakhya, Robert Axelsson
-
Publication number: 20210186797Abstract: A pressure therapy device includes a pressure chamber, an inflatable padding, a seal, and a positioning mechanism. The pressure chamber has an opening arranged for admitting the inflatable padding and a limb of a user. The inflatable padding is inflatable to enclose and fix the limb in position. The seal covers the opening, including the inflatable padding and the limb to seal the pressure chamber from ambient atmospheric pressure. A pump unit is provided to generate a non-atmospheric pressure within the pressure chamber and includes a first valve system and a piston with safety release features for preventing unsafe pressure levels.Type: ApplicationFiled: March 5, 2021Publication date: June 24, 2021Inventors: Jonas ELDERSTIERN, Hannes ULVEGARD, Ronny BRAKHYA, Robert AXELSSON, Juho LAASANEN, Iacob MATHIESEN, Arnar KRISTJANSSON
-
Patent number: 10940075Abstract: A pressure therapy device includes a pressure chamber, an inflatable padding, a seal, and a positioning mechanism. The pressure chamber has an opening arranged for admitting the inflatable padding and a limb of a user. The inflatable padding is inflatable to enclose and fix the limb in position. The seal covers the opening, including the inflatable padding and the limb to seal the pressure chamber from ambient atmospheric pressure. A pump unit is provided to generate a non-atmospheric pressure within the pressure chamber and includes a first valve system and a piston with safety release features for preventing unsafe pressure levels.Type: GrantFiled: October 1, 2018Date of Patent: March 9, 2021Assignee: OTIVIO ASInventors: Jonas Elderstiern, Hannes Ulvegard, Ronny Brakhya, Robert Axelsson, Juho Laasanen, Iacob Mathiesen, Arnar Kristjansson
-
Publication number: 20200001076Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.Type: ApplicationFiled: July 9, 2019Publication date: January 2, 2020Inventors: Rune KJEKEN, Iacob MATHIESEN, Elisabeth Torunn TJELLE, George McHUGH
-
Publication number: 20190351225Abstract: An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising: a hollow needle; and fluid delivery means, wherein the apparatus is adapted to actuate the fluid delivery means in use so as to automatically inject fluid into body tissue during insertion of the needle into the said body tissue.Type: ApplicationFiled: August 5, 2019Publication date: November 21, 2019Inventors: Iacob Mathiesen, Torunn E. Tjelle, Knut Arvid Sorensen Rekdahl, Bjorn David-Andersen
-
Patent number: 10376692Abstract: An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising: a hollow needle; and fluid delivery means, wherein the apparatus is adapted to actuate the fluid delivery means in use so as to automatically inject fluid into body tissue during insertion of the needle into the said body tissue.Type: GrantFiled: February 19, 2016Date of Patent: August 13, 2019Assignee: Inovio ASInventors: Iacob Mathiesen, Torunn E. Tjelle, Knut Arvid Sorensen Rekdahl, Bjorn David-Andersen
-
Patent number: 10369359Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.Type: GrantFiled: February 9, 2007Date of Patent: August 6, 2019Assignee: Genetronics, Inc.Inventors: Rune Kjeken, Iacob Mathiesen, Elisabeth Torunn Tjelle, George McHugh
-
Publication number: 20190099321Abstract: A pressure therapy device includes a pressure chamber, an inflatable padding, a seal, and a positioning mechanism. The pressure chamber has an opening arranged for admitting the inflatable padding and a limb of a user. The inflatable padding is inflatable to enclose and fix the limb in position. The seal covers the opening, including the inflatable padding and the limb to seal the pressure chamber from ambient atmospheric pressure. A pump unit is provided to generate a non-atmospheric pressure within the pressure chamber and includes a first valve system and a piston with safety release features for preventing unsafe pressure levels.Type: ApplicationFiled: October 1, 2018Publication date: April 4, 2019Inventors: Jonas Elderstiern, Hannes Ulvegard, Ronny Brakhya, Robert Axelsson, Juho Laasanen, Iacob Mathiesen, Arnar Kristjansson
-
Publication number: 20190099322Abstract: A pressure therapy device includes a pressure chamber, an inflatable padding, a seal, and a positioning mechanism. The pressure chamber has an opening arranged for admitting the inflatable padding and a limb of a user. The inflatable padding is inflatable to enclose and fix the limb in position. The seal covers the opening, including the inflatable padding and the limb to seal the pressure chamber from ambient atmospheric pressure. A pump unit is provided to generate a non-atmospheric pressure within the pressure chamber and includes a first valve system and a piston with safety release features for preventing unsafe pressure levels.Type: ApplicationFiled: October 1, 2018Publication date: April 4, 2019Inventors: Jonas Elderstiern, Hannes Ulvegard, Ronny Brakhya, Robert Axelsson, Iacob Mathiesen, Arnar Kristjansson
-
Publication number: 20190099312Abstract: A pressure therapy device includes a pressure chamber, an inflatable padding, a seal, and a positioning mechanism. The pressure chamber has an opening arranged for admitting the inflatable padding and a limb of a user. The inflatable padding is inflatable to enclose and fix the limb in position. The seal covers the opening, including the inflatable padding and the limb to seal the pressure chamber from ambient atmospheric pressure. A pump unit is provided to generate a non-atmospheric pressure within the pressure chamber and includes a first valve system and a piston with safety release features for preventing unsafe pressure levels.Type: ApplicationFiled: October 1, 2018Publication date: April 4, 2019Inventors: Juho LAASANEN, Sanna TUONONEN, Petri RANTANEN, Joachim RASMUSSEN, Andreas ERLANDSEN, Jakob PETTERSEN, Marius ANDRESEN, Iacob MATHIESEN, Arnar KRISTJANSSON, Jonas ELDERSTIERN, Hannes ULVEGARD, Ronny BRAKHYA, Robert AXELSSON
-
Publication number: 20170360649Abstract: Medical pressure therapy can be used on a patient having undergone treatment to reopen an arterial obstruction, such as a stenosis or occlusion. The medical pressure therapy can establish and maintain persistently good distal runoff. The can help ensure the patency of the region having undergone the treatment procedure. In some examples, the technique involves enclosing at least a portion of a limb of a patient on which an obstruction treatment procedure has been performed in an enclosure such that the portion of the limb is sealed from external conditions. The technique further involves alternately applying a negative pressure within the enclosure and releasing the negative pressure from within the enclosure, thereby increasing a volume and velocity of blood flowing past a region of the blood vessel previously-obstructed and thereby increasing distal runoff.Type: ApplicationFiled: June 21, 2017Publication date: December 21, 2017Inventors: Jonny Hisdal, Øyvind Heiberg Sundby, Iacob Mathiesen
-
Publication number: 20160213921Abstract: An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising: a hollow needle; and fluid delivery means, wherein the apparatus is adapted to actuate the fluid delivery means in use so as to automatically inject fluid into body tissue during insertion of the needle into the said body tissue.Type: ApplicationFiled: February 19, 2016Publication date: July 28, 2016Inventors: Iacob MATHIESEN, Torunn E. TJELLE, Knut Arvid Sorensen REKDAHL, Bjorn DAVID-ANDERSEN
-
Patent number: 7931640Abstract: A method is disclosed for delivering molecules such as pharmaceutical drugs and nucleic acids into skeletal muscle in vivo. The molecule is first injected into the muscle at one or multiple sites. Immediately or shortly after injection, electrodes are placed flanking the injection site and a specific amount of electrical current is passed through the muscle. The electrical current makes the muscle permeable, thus allowing the molecule to enter the cell. In the case where nucleic acid is injected, the efficiency of transfer permits expression of protein encoded by the nucleic acid in an amount that exhibits systemic biological activity and which generates a robust immune response.Type: GrantFiled: February 15, 2008Date of Patent: April 26, 2011Assignee: Inovio ASInventors: Iacob Mathiesen, Terje Lomo