Publication number: 20040038991
Abstract: Compounds of formula (I) are described in which R1 is optionally substituted heteroaryl; R2 is optionally substituted aryl or optionally substituted heteroaryl; R3 is a group -L1-R7 or -L2-R8 [where L1 is an optionally substituted alkylene linkage; R7 is hydrogen, aryl, cyano, cycloalkyl, heteroaryl, heterocycloalkyl, nitro, —S(O)nR9, —NHSO2R9, —C(=Z)OR10, —C(=Z)R10, —OR10, —N(R11)—C(=Z)R9, —NY1Y2, —SO2—NY1Y2, —C(=Z)-NY1Y2, —N(R11)—C(=Z)-NY1Y2, —N(OR10)—C(=Z)-NY1Y2, —N(OR10)—C(=Z)R10, —C(=NOR10)R10, —C(=Z)NR10OR12, —N(R11)—C(═NR13)—NY1Y2 or —N(R11)—C(=Z)OR11; L2 is a direct bond or a straight- or branched-carbon chain comprising from 2 to about 6 carbon atoms and contains a double or triple carbon-carbon bond; and R8 is hydrogen, aryl, cycloalkenyl, cycloalkyl, heteroaryl or heterocycloalk
Type:
Application
Filed:
May 13, 2003
Publication date:
February 26, 2004
Applicant:
AVENTIS PHARMA LIMITED
Inventors:
Paul L. Bamborough, Alan J. Collis, Frank Halley, Richard A. Lewis, David J. Lythgoe, Jeffrey M. McKenna, Iain M. McLay, Barry Porter, Andrew J. Ratcliffe, Paul A. Wallace
Patent number: 6602877
Abstract: Compounds of formula (I) are described in which R1 is optionally substituted heteroaryl; R2 is optionally substituted aryl or optionally substituted heteroaryl; R3 is a group —L1—R7 or —L2—R8 [where L1 is an optionally substituted alkylene linkage; R7 is hydrogen, aryl, cyano, cycloalkyl, heteroaryl, heterocycloalkyl, nitro, —S(O)nR9, —NHSO2R9, —C(═Z)OR10, —C(═Z)R10, —OR10, —N(R11)—C(═Z)R9, —NY1Y2, —SO2NY1Y2, —C(═Z)—NY1Y2, —N(R11)—C(═Z)—NY1Y2, —N(OR10)—C(═Z)—NY1Y2, —N(OR10)—C(═Z)R10, —C(═NOR10)R10, —C(═Z)NR10OR12, —N(R11)—C(═NR13)—NY1Y2 or —N(R11)—C(═Z)OR11; L2 is a direct bond or a straight- or branched-carbon chain comprising from 2 to about 6 carbon atoms and contains a double or triple carbon-carbon bond; and R8 is hydrogen, aryl, cycloalkenyl, cycloalkyl, heteroaryl or
Type:
Grant
Filed:
December 8, 1999
Date of Patent:
August 5, 2003
Assignee:
Aventis Pharma Limited
Inventors:
Paul L. Bamborough, Alan J. Collis, Frank Halley, Richard A. Lewis, David J. Lythgoe, Jeffrey M. McKenna, Iain M. McLay, Barry Porter, Andrew J. Ratcliffe, Paul A. Wallace