Abstract: Methods and apparatus for making lens assemblies that can be placed on an eye of a person and that include at least one component are described. Generally, a first lens member (100) and a second lens member (200) are formed. The second lens member (200) is transferred to a compliant stage (210). At least one component is placed in contact with one of the lens members (100, 200). The second lens member (200) is placed in contact with the first lens member (100) such that the compliant stage (210) can provide compression to the first and second lens members (100, 200). The second lens member (200) and the first lens member (100) are coupled together to form a lens assembly (10) with the at least one component located between the two lens members (100, 200).

Abstract: A method of manufacturing a contact lens 110 is disclosed. The method comprises manufacturing a rod of lens material 101, the rod 101 containing a plurality of electronic components 102 spaced apart along its length, separating the rod 101 into a plurality of lens blanks 106, each lens blank 106 containing at least one of said electronic components 102, and machining the front and/or back surface of a lens blank 106 to produce a contact lens 110 containing the at least one electronic component 102.

Abstract: The present application provides a method and system for the characterization of properties of liquids, particularly petroleum and petroleum liquids. The method and system can be used to take measurements of the liquid directly in a storage container, without exposing the contents of the container to the external environment.

Abstract: Ophthalmic device molds made from a first portion of a molding surface formed from a first polymer and a second portion of the molding surface formed from a second polymer are described. When combined, the first portion and the second portion of the molding surface form an entire molding surface suitable for molding an entire surface, such as an anterior surface or a posterior surface of an ophthalmic device. Methods of manufacturing ophthalmic devices using these molds, including contact lenses, are also described.

Abstract: The present disclosure describes a networking switch of a network and method for operating the networking switch. The networking switch communicates within the network using datagrams, such as packets and/or frames. The frames include packets of a first communication protocol or layer having headers of the first communication protocol or layer. In some situations, the packets of the first communication protocol or layer are embedded with packets of a second communication protocol or layer. Often times, one or more fields of headers of the first communication protocol or layer convey substantially similar or redundant information, such as routing information to provide an example, as one or more fields of headers of the second communication protocol or layer.

Abstract: The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

Abstract: The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

Abstract: Ophthalmic device molds made from at least one water-soluble vinyl alcohol copolymer, ophthalmic devices such as ocular inserts and contact lenses and including silicone hydrogel devices formed using these molds, packaged ophthalmic devices present in a solution comprising the at least one water-soluble vinyl alcohol copolymer, and related methods are described. The methods of manufacturing ophthalmic devices can use wet demolding processes, or wet delensing processes or both wet demolding and wet delensing processes involving dissolving the molds in water or an aqueous solution.

Abstract: The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

Abstract: The present invention concerns a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, where R1-R3 and Y are defined in the description, and its use in the treatment of disorders in which pi3 kinase is implicated.

Abstract: An emergency anti-hypothermia system has a thermally insulating vest that is sufficiently portable to be carried for emergency use in a pocket, purse, backpack, compartment of a vehicle, ski pole or other location, with the vest providing thermal insulation by being made with thermally insulating air impervious material that also provides for its inflation. A multiplicity of interconnected inflated chambers situated about the vest, provides thermal insulation by anti-conduction, anti-radiation and anti-convection in a highly portable system. An outer surface having radar reflective properties further improves visibility of the vest.

Abstract: A method of manufacturing a contact lens 110 is disclosed. The method comprises manufacturing a rod of lens material 101, the rod 101 containing a plurality of electronic components 102 spaced apart along its length, separating the rod 101 into a plurality of lens blanks 106, each lens blank 106 containing at least one of said electronic components 102, and machining the front and/or back surface of a lens blank 106 to produce a contact lens 110 containing the at least one electronic component 102.

Abstract: The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

Abstract: A method for manufacturing a silicone hydrogel contact lens is described that comprises curing a polymerizable composition comprising at least one siloxane monomer and at least one hydrophilic vinyl-containing monomer in a contact lens mold comprising a molding surface having a coating comprising a hydrophilic polymer. The hydrophilic coating is not solubilized by the polymerizable composition during the curing step. The resulting polymeric lens body is removed from the mold, washed to remove any of the hydrophilic polymer that may have transferred from the mold surface to the lens during the curing or lens removal process, and packaged to provide a silicone hydrogel contact lens having a contact angle that is lower than what it would otherwise be had the lens been cured in the same contact lens mold lacking the hydrophilic coating.

Abstract: Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. wherein A is and R1, R1a, R2, R3, R4, R5, R6 and X are as defined herein.

Abstract: Ophthalmic lens molds made from at least one vinyl alcohol copolymers with high amorphous content, ophthalmic lenses including silicone hydrogel contact lenses formed using these molds, packaged ophthalmic lenses present in a solution comprising the at least one vinyl alcohol copolymer with high amorphous content, and related methods are described. The methods of manufacturing ophthalmic lenses can use wet demolding, delensing or demolding and delensing processes involving dissolving the molds in water or an aqueous solution.

Abstract: An emergency anti-hypothermia system has a thermally insulating vest that is sufficiently portable to be carried for emergency use in a pocket, purse, backpack, compartment of a vehicle, ski pole or other location, with the vest providing thermal insulation by being made with thermally insulating air impervious material that also provides for its inflation. A multiplicity of interconnected inflated chambers situated about the vest, provides thermal insulation by anti-conduction, anti-radiation and anti-convection in a highly portable system. An outer surface having radar reflective properties further improves visibility of the vest.

Abstract: Ophthalmic lens molds made from at least one vinyl alcohol copolymers with high amorphous content, ophthalmic lenses including silicone hydrogel contact lenses formed using these molds, packaged ophthalmic lenses present in a solution comprising the at least one vinyl alcohol copolymer with high amorphous content, and related methods are described. The methods of manufacturing ophthalmic lenses can use wet demolding, delensing or demolding and delensing processes involving dissolving the molds in water or an aqueous solution.

Abstract: Ophthalmic device molds made from at least one highly amorphous vinyl alcohol polymer, ophthalmic devices such as ocular inserts and contact lenses and including silicone hydrogel devices formed using these molds, and related methods are described. The methods of manufacturing ophthalmic devices can use dry or wet demolding processes, or dry or wet delensing processes.

Abstract: Ophthalmic device molds made from at least one vinyl alcohol copolymer and having a static sessile drop contact angle of less than 70 degrees, ophthalmic devices such as ocular inserts and contact lenses and including silicone hydrogel devices formed using these molds, and related methods are described. The methods of manufacturing ophthalmic devices can use dry or wet demolding processes, or dry or wet delensing processes.