Patents by Inventor Ian Christopher Parsons
Ian Christopher Parsons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10317410Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.Type: GrantFiled: April 6, 2017Date of Patent: June 11, 2019Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
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Patent number: 9933432Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.Type: GrantFiled: August 19, 2016Date of Patent: April 3, 2018Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
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Publication number: 20170212129Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.Type: ApplicationFiled: April 6, 2017Publication date: July 27, 2017Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
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Publication number: 20160356783Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.Type: ApplicationFiled: August 19, 2016Publication date: December 8, 2016Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
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Patent number: 9448147Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.Type: GrantFiled: November 8, 2013Date of Patent: September 20, 2016Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
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Patent number: 9182467Abstract: The present disclosure provides a method for determining the relative conformations of a protein provided in different protein preparations, comprising steps of: (i) obtaining a first 2D NOESY NMR spectrum of a first protein preparation; (ii) obtaining a second 2D NOESY NMR spectrum of a second protein preparation; and (iii); determining whether a protein has a different conformation in the first and second protein preparations by comparing one or more cross-peaks in the first 2D NOESY NMR spectrum with one or more corresponding cross-peaks in the second 2D NOESY NMR spectrum.Type: GrantFiled: April 15, 2008Date of Patent: November 10, 2015Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Jonathan Lansing, Carlos J. Bosques, Daniela Beccati
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Patent number: 9029081Abstract: The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the present disclosure involve comparison of cleavage products of N-glycans that have been digested with multiple exoglycosidases simultaneously to N-glycans that have been digested with multiple exoglycosidases sequentially.Type: GrantFiled: December 19, 2012Date of Patent: May 12, 2015Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Dorota A. Bulik, Carlos J. Bosques, Lakshmanan Thiruneelakantapillai, Brian Edward Collins
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Publication number: 20140127735Abstract: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.Type: ApplicationFiled: January 14, 2014Publication date: May 8, 2014Applicant: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Jonathan Lansing, Daniela Becatti, Scott Bailey, Carlos J. Bosques
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Patent number: 8703498Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.Type: GrantFiled: September 28, 2012Date of Patent: April 22, 2014Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
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Publication number: 20140065716Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.Type: ApplicationFiled: November 8, 2013Publication date: March 6, 2014Applicant: MOMENTA PHARMACEUTICALS, INC.Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
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Patent number: 8663999Abstract: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.Type: GrantFiled: June 8, 2012Date of Patent: March 4, 2014Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Jonathan Lansing, Daniela Becatti, Scott Bailey, Carlos J. Bosques
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Publication number: 20130069645Abstract: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.Type: ApplicationFiled: June 8, 2012Publication date: March 21, 2013Applicant: MOMENTA PHARMACEUTICALS, INC.Inventors: Ian Christopher Parsons, Jonathan Lansing, Daniela Beccatti, Scott Bailey, Carlos J. Bosques
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Patent number: 8361705Abstract: The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the present disclosure involve comparison of cleavage products of N-glycans that have been digested with multiple exoglycosidases simultaneously to N-glycans that have been digested with multiple exoglycosidases sequentially.Type: GrantFiled: April 15, 2008Date of Patent: January 29, 2013Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Dorota A. Bulik, Carlos J. Bosques, Lakshmanan Thiruneelakantapillai, Brian Edward Collins
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Patent number: 8338088Abstract: The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.Type: GrantFiled: April 15, 2008Date of Patent: December 25, 2012Assignee: Momenta Pharmaceuticals, Inc.Inventors: Brian Edward Collins, Carlos J. Bosques, Xiangping Zhu, Dorota A. Bulik, Lakshmanan Thiruneelakantapillai, Ian Christopher Parsons, Zachary Shriver, Rajeev Chillakuru, Ganesh Venkataraman
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Patent number: 8304250Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.Type: GrantFiled: April 15, 2008Date of Patent: November 6, 2012Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
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Publication number: 20120264927Abstract: Methods for labeling glycans that include a step of freeze-drying a labeled glycan preparation. The labeled glycan preparation is maintained in a substantially frozen state for the duration of the freeze-drying process.Type: ApplicationFiled: April 15, 2008Publication date: October 18, 2012Inventors: Ian Christopher Parsons, Lakshmanan Thiruneelakantapillai, Carlos J. Bosques, Brian Edward Collins
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Patent number: 8216851Abstract: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.Type: GrantFiled: April 15, 2008Date of Patent: July 10, 2012Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Jonathan Lansing, Daniela Beccati, Scott Bailey, Carlos J. Bosques
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Patent number: 8043863Abstract: The present disclosure provides, among other things, methods for the identification of sulfated glycans in a mixture of glycans.Type: GrantFiled: April 15, 2008Date of Patent: October 25, 2011Assignee: Momenta Pharmaceuticals, Inc.Inventors: Carlos J. Bosques, Nathaniel J. Washburn, Xiangping Zhu, Ian Christopher Parsons
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Publication number: 20110213137Abstract: The present disclosure provides methods of making isotopically-labeled glycans or a mixture of glycans (e.g., a glycan preparation) via reductive amination. Such methods are useful, for example, in the determination of the relative amounts of a glycan species present in two or more glycoprotein preparations using mass spectroscopy. In one aspect, the present disclosure provides a method of making an isotopically-labeled glycan by a glycan with an amine and an isotopically-labeled reducing agent to provide an isotopically-labeled aminated glycan. In certain embodiments, the amine is an isotopically-labeled amine.Type: ApplicationFiled: April 15, 2008Publication date: September 1, 2011Applicant: MOMENTA PHARMACEUTICALS, INC.Inventors: Carlos J. Bosques, Ian Christopher Parsons, Lakshmanan Thiruneelakantapillai, Brian Edward Collins, Hetal Sarvaiya
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Publication number: 20100279306Abstract: The present disclosure provides technologies for enriching, detecting, and/or quantifying phosphorylated glycans and/or glycoconjugates (e.g., glycopeptides, glycolipids, proteoglycans, etc.). Specifically, the present disclosure provides methods that utilize immobilized metal affinity chromatography (IMAC) to isolate and/or to characterize phosphorylated glycans. The present disclosure particularly provides methods for distinguishing sulfated and phosphorylated glycans.Type: ApplicationFiled: April 15, 2008Publication date: November 4, 2010Applicant: Momenta Pharmaceuticals, Inc.Inventors: Carlos J. Bosques, Lakshmanan Thiruneelakantapillai, Ian Christopher Parsons