Patents by Inventor Ian Fotheringham

Ian Fotheringham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Endotoxin-free Production of Recombinant Subunit Vaccine Components
    Publication number: 20220282264
    Abstract: An endotoxin-free production of recombinant subunit vaccine components, and production methods thereof, using a synthetic virus-like-particle (VLP) to which is attached (and displayed) a fragment of the coronavirus “spike” protein, the Receptor Binding Domain (RBD) and wherein the VLP is produced very effectively using engineered B. subtilis.
    Type: Application
    Filed: February 17, 2022
    Publication date: September 8, 2022
    Inventors: Ian Fotheringham, Leonardo Magneschi, Rita Alexandra Leal Cruz
  • Detection of Optimal Recombinants Using Fluorescent Protein Fusions
    Publication number: 20210206810
    Abstract: A detection of optimal genetic recombinants used to prepare target proteins, with assessment of their target-specific “upstream” productivity, genetic stability and means to optimize target protein “downstream” purification using customizable fluorescent tags. A scarless removable protein fusion makes it possible to identify recombinants of Pichia pastoris with optimal performance in heterologous protein production.
    Type: Application
    Filed: November 19, 2020
    Publication date: July 8, 2021
    Inventors: Ian Fotheringham, Annemette Kjeldsen, Leonardo Magneschi, Harveen Erskine, Scott Baxter, Stephen McColm, Cristina Serrano-Amatriain, David McElroy, Jack Eric Kay
  • Mutants for the preparation of D-amino acids
    Patent number: 9194009
    Abstract: Escherichia. coli mutants which can be used for the synthesis of D-amino acids, and to such a process. The mutants are distinguished by deficiencies in particular enzymes which break down D-amino acids and include those which produce D-amino acids via the carbamoylase/hydantoinase route.
    Type: Grant
    Filed: January 21, 2009
    Date of Patent: November 24, 2015
    Assignee: EVONIK DEGUSSA GmbH
    Inventors: Oliver May, Stefan Buchholz, Michael Schwarm, Karlheinz Drauz, Robert J. Turner, Ian Fotheringham
  • COMPOSITIONS AND METHODS OF PRODUCING ENTEROKINASE IN YEAST
    Publication number: 20130302853
    Abstract: The present specification disclose polynucleotide molecules encoding an enterokinase, yeast expression constructs including a yeast expression vector and a polynucleotide molecules encoding an enterokinase, yeast cells comprising such a yeast expression construct, methods of producing enterokinase using such yeast cells, and method of cleaving or preparing a recombinant polypeptide using an enterokinase produced by such methods.
    Type: Application
    Filed: July 26, 2013
    Publication date: November 14, 2013
    Inventors: Ian Fotheringham, Peter Sheffield
  • Compositions and methods of producing enterokinase in yeast
    Patent number: 8557558
    Abstract: The present specification disclose polynucleotide molecules encoding an enterokinase, yeast expression constructs including a yeast expression vector and a polynucleotide molecules encoding an enterokinase, yeast cells comprising such a yeast expression construct, methods of producing enterokinase using such yeast cells, and method of cleaving or preparing a recombinant polypeptide using an enterokinase produced by such methods.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: October 15, 2013
    Assignee: Allergan, Inc.
    Inventors: Ian Fotheringham, Peter Sheffield
  • Compositions and Methods of Producing Enterokinase in Yeast
    Publication number: 20120156720
    Abstract: The present specification disclose polynucleotide molecules encoding an enterokinase, yeast expression constructs including a yeast expression vector and a polynucleotide molecules encoding an enterokinase, yeast cells comprising such a yeast expression construct, methods of producing enterokinase using such yeast cells, and method of cleaving or preparing a recombinant polypeptide using an enterokinase produced by such methods.
    Type: Application
    Filed: November 23, 2011
    Publication date: June 21, 2012
    Applicant: ALLERGAN, INC.
    Inventors: IAN FOTHERINGHAM, PETER SHEFFIELD
  • Stereoinversion of amino acids in a single reactor
    Patent number: 8133717
    Abstract: A process is described to prepare a single enantiomer of an amino acid from its opposite enantiomer or from a racemic mixture, using an oxidase biocatalyst and a supported metal catalyst in separate, sequential reactions in water. The process can be operated in batch or continuous mode.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: March 13, 2012
    Assignee: Richmond Chemical Corporation
    Inventors: Ian Victor James Archer, Ian Fotheringham, Rueben Carr, Susan Alison Arnold
  • Method to increase the yield and improve purification of products from transaminase reactions
    Patent number: 8076106
    Abstract: A process for producing high yields of enantioselective amino acids and chiral amines by reacting a keto acid or ketone and an amino acid donor in the presence of a transaminase biocatalyst to produce a keto acid by-product and an amino acid or amine product. Further reacting the keto acid by-product with a peroxide to increase the yield of additional amino acid or amine product.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: December 13, 2011
    Assignee: Richmond Chemical Corporation
    Inventors: Ian Fotheringham, Nicholas Oswald
  • Methods for Production of Xylitol in Microorganisms
    Publication number: 20110212458
    Abstract: The invention provides biosynthetic routes to xylitol production that do not require pure D-xylose for synthesis and that can utilize inexpensive substrates such as hemicellulose hydrolysates.
    Type: Application
    Filed: May 11, 2011
    Publication date: September 1, 2011
    Inventors: Paul Taylor, Ian Fotheringham, Nathan Wymer, Badal Saha, David Demirjian, Yoshikiyo Sakaibara, Francis Michael Racine
  • Methods for production of xylitol in microorganisms
    Patent number: 7960152
    Abstract: The invention provides biosynthetic routes to xylitol production that do not require pure D-xylose for synthesis and that can utilize inexpensive substrates such as hemicellulose hydrolysates.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: June 14, 2011
    Assignee: Biotechnology Research Development Corporation
    Inventors: Paul Taylor, Ian Fotheringham, Nathan Wymer, Badal Saha, David Demirjian, Yoshikiyo Sakaibara, Francis Michael Racine
  • Method to increase the yield and improve purification of products from transaminase reactions
    Publication number: 20090298134
    Abstract: A process for producing high yields of enantioselective amino acids and chiral amines by reacting a keto acid or ketone and an amino acid donor in the presence of a transaminase biocatalyst to produce a keto acid by-product and an amino acid or amine product. Further reacting the keto acid by-product with a peroxide to increase the yield of additional amino acid or amine product.
    Type: Application
    Filed: August 6, 2009
    Publication date: December 3, 2009
    Inventors: Ian Fotheringham, Nicholas Oswald
  • Method to increase the yield and improve purification of products from transaminase reactions
    Patent number: 7588923
    Abstract: A process for producing high yields of enantioselective amino acids and chiral amines by reacting a keto acid or ketone and an amino acid donor in the presence of a transaminase biocatalyst to produce a keto acid by-product and an amino acid or amine product. Further reacting the keto acid by-product with a peroxide to increase the yield of additional amino acid or amine product.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: September 15, 2009
    Assignee: Richmond Chemical Corporation
    Inventors: Ian Fotheringham, Nicholas Oswald
  • MUTANTS FOR THE PREPARATION OF D-AMINO ACIDS
    Publication number: 20090203091
    Abstract: The present invention relates to specific Escherichia. coli mutants which can be used for the synthesis of D-amino acids, and to such a process. The mutants are distinguished by deficiencies in particular enzymes which break down D-amino acids and include those which produce D-amino acids via the carbamoylase/hydantoinase route.
    Type: Application
    Filed: January 21, 2009
    Publication date: August 13, 2009
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Oliver MAY, Stefan Buchholz, Michael Schwarm, Karlheinz Drauz, Robert J. Turner, Ian Fotheringham
  • Method for detecting biofuel producing microbes
    Publication number: 20090029401
    Abstract: A method for detecting biofuel producing microbes in a colorimetric assay by providing a microbe, a feedstock, and an assay solution. The assay solution contains an alcohol oxidase, a peroxidase, and a peroxidase co-substrate. The microbe is cultured with the feedstock as part of a culture medium that produces a detectable amount of bioalcohol. The culture medium is contacted with the assay solution to produce a colorimetric reaction to screen for a biofuel producing microbe.
    Type: Application
    Filed: July 24, 2008
    Publication date: January 29, 2009
    Inventors: Ian Fotheringham, Nicole Kaftzik, Nicholas Oswald
  • Method to increase the yield and improve purification of products from transaminase reactions
    Publication number: 20080213845
    Abstract: A process for producing high yields of enantioselective amino acids and chiral amines by reacting a keto acid or ketone and an amino acid donor in the presence of a transaminase biocatalyst to produce a keto acid by-product and an amino acid or amine product. Further reacting the keto acid by-product with a peroxide to increase the yield of additional amino acid or amine product.
    Type: Application
    Filed: February 29, 2008
    Publication date: September 4, 2008
    Inventors: Ian Fotheringham, Nicholas Oswald
  • STEREOINVERSION OF AMINO ACIDS
    Publication number: 20080153137
    Abstract: A process is described to prepare a single enantiomer of an amino acid from its opposite enantiomer or from a racemic mixture, using an oxidase biocatalyst and a supported metal catalyst in separate, sequential reactions in water. The process can be operated in batch or continuous mode.
    Type: Application
    Filed: December 21, 2007
    Publication date: June 26, 2008
    Applicant: Richmond Chemical Corporation
    Inventors: Ian Victor James Archer, Ian Fotheringham, Reuben Carr, Susan Alison Arnold
  • Mutants for the preparation of d-amino acids
    Publication number: 20060228787
    Abstract: The present invention relates to specific E. coli mutants which can be used for the synthesis of D-amino acids, and to such a process. The mutants are distinguished by deficiencies in particular enzymes which break down D-amino acids.
    Type: Application
    Filed: October 15, 2003
    Publication date: October 12, 2006
    Inventors: Oliver May, Stefan Buchholz, Karlheinz Drauz, Michael Schwarm, Robert Turner, Ian Fotheringham
  • Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use
    Publication number: 20060199254
    Abstract: The invention provides the nucleotide sequence and amino acid sequence for the enzyme carboxylic acid reductase isolated from bacteria. Expression cassettes, vectors, transformed cells, and variants are also provided as methods for use of recombinant biocatalytic reagents in production of synthetic, aromatic, aliphatic and alicyclic aldehydes and alcohols.
    Type: Application
    Filed: May 10, 2006
    Publication date: September 7, 2006
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION, INC.
    Inventors: John Rosazza, Ian Fotheringham, Tao Li, Lacy Daniels, Aimin He
  • Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use
    Patent number: 7056714
    Abstract: The invention provides the nucleotide sequence and amino acid sequence for the enzyme carboxylic acid reductase isolated from bacteria. Expression cassettes, vectors, transformed cells, and variants are also provided as methods for use of recombinant biocatalytic reagents in production of synthetic, aromatic, aliphatic and alicyclic aldehydes and alcohols.
    Type: Grant
    Filed: March 11, 2003
    Date of Patent: June 6, 2006
    Assignee: University of Iowa Research Foundation, Inc.
    Inventors: John P. Rosazza, Ian Fotheringham, Tao Li, Lacy Daniels, Aimin He
  • Methods for production of xylitol in microorganisms
    Publication number: 20060110809
    Abstract: The invention provides biosynthetic routes to xylitol production that do not require pure D-xylose for synthesis and that can utilize inexpensive substrates such as hemicellulose hydrolysates.
    Type: Application
    Filed: May 19, 2005
    Publication date: May 25, 2006
    Inventors: Paul Taylor, Ian Fotheringham, Nathan Wymer, Badal Saha, David Demirjian, Yoshikiyo Sakaibara, Francis Racine