Abstract: There is described a handle, for example a door handle, lifting handle or touch pad, which is particularly useful as a self-sterilizing door handle for use in public areas. The handle comprises: a contact area formed of a hydrophilic sintered porous material, particularly a plastic material; and a reservoir containing an anti-microbial liquid, wherein said reservoir is fluidically connected to the contact area. The reservoir can include a port to allow the reservoir to be re-filled or alternatively the whole reservoir can be detached and replaced when required. The anti-microbial liquid can be delivered along the hydrophilic sintered porous material by fluid transmission action so that the contact area is continually treated by the anti-microbial liquid, thereby rendering the handle continuously wetted and disinfected and inhibiting the growth of culture forming units.

Abstract: A method for ranking performance of each production well in a plurality of production wells includes sensing a production parameter value for each production well using a sensor and receiving the production parameter value for each production well using a processor. The method also includes performing two or more different calculations for each production well using the production parameter value, each calculation providing a calculated performance indicator, multiplying each calculated performance indicator by a weight factor to provide a weighted performance indicator; and summing each of the weighted performance indicators for each production well to provide a unit-less performance index value for each production well.

Abstract: An engine assembly for a motor vehicle is provided. The assembly comprises a bearing housing portion configured to support a bearing for a crankshaft of the engine assembly, wherein the bearing housing portion comprises a bearing interface surface configured to interface with the bearing and an end face adjacent to the bearing interface surface, the end face being arranged so as to face a web of the crankshaft when installed. The engine assembly further comprises an insulation layer provided on the end face, the insulation layer being positioned such that the insulation layer is between the bearing housing portion and the web of the crankshaft when the crankshaft is installed in the engine assembly.

Abstract: A machine having a cylinder, the configuration of the machine being such that a body portion of a piston of the machine periodically engages an inner surface of the cylinder during operation of the machine, this engagement defining a contact zone between the body portion of the piston and the inner surface of the cylinder, the inner surface of the cylinder having an enhanced bearing region comprising one or more recesses indented into the inner surface, the enhanced bearing region being smaller than the inner surface of the cylinder and being substantially centered on the contact zone.

Abstract: An engine assembly is provided. The engine assembly comprises an oil system comprising: a first oil pump configured to supply oil at a first pressure to one or more first components of the engine assembly; and a second oil pump configured to supply oil at a second pressure to one or more second components of the engine assembly, the second pressure being higher than the first pressure; wherein the second oil pump is provided adjacent to a valve train of the engine assembly.

Abstract: A crankcase oil catcher, the crankcase oil catcher comprising one or more surfaces configured to catch dispersed oil in a crankcase and direct the oil along the surfaces of the crankcase oil catcher away from a crankcase casing wall and towards a crank sump.

Abstract: Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like Duchene Muscular Dystrophy so that the disease is more like Becker Muscular Dystrophy. This is a severe reduction in symptom severity and mortality.

Abstract: The disclosure relates to delta (12) and delta (15) desaturases and their use in the modification of oil content in hemp.

Abstract: A bearing interface of an apparatus, the apparatus having a first element and a second element configured to move relative to each other during operation of the apparatus, the first element comprising a first bearing surface configured to engage at least a portion of a second bearing surface of the second element thereby defining a contact zone between the first bearing surface and the second bearing surface, the first bearing surface having at least one recess indented into the first bearing surface, wherein the dimension of the recess in the direction of movement of the second element relative to the first element is less than the dimension of the contact zone in the direction of movement of the second element.

Abstract: There is described a handle, for example a door handle, lifting handle or touch pad, which is particularly useful as a self-sterilising door handle for use in public areas. The handle comprises: a contact area formed of a hydrophilic sintered porous material, particularly a plastic material; and a reservoir containing an anti-microbial liquid, wherein said reservoir is fluidically connected to the contact area. The reservoir can include a port to allow the reservoir to be re-filled or alternatively the whole reservoir can be detached and replaced when required. The anti-microbial liquid can be delivered along the hydrophilic sintered porous material by fluid transmission action so that the contact area is continually treated by the anti-microbial liquid, thereby rendering the handle continuously wetted and disinfected and inhibiting the growth of culture forming units.

Abstract: A system, computer-readable storage medium storing at least one program, and a computer-implemented method for generating game configurations are presented. For example, a system may receive a game configuration request message from a client device being operated by a player playing a virtual game. The game configuration request message may be sent, for example, in response to the player initiating a new game of the virtual game. The system may then select a game configuration based at least in part on historical performance data associated with the selected game configuration. The historical performance data may accumulate performance data from a group of players that previously played the virtual game using the selected game configuration. The system then communicates the selected game configuration to the client device. The player may play the virtual game using the selected game configuration as the initial game configuration for the virtual game.

Abstract: A method for ranking performance of each production well in a plurality of production wells includes sensing a production parameter value for each production well using a sensor and receiving the production parameter value for each production well using a processor. The method also includes performing two or more different calculations for each production well using the production parameter value, each calculation providing a calculated performance indicator, multiplying each calculated performance indicator by a weight factor to provide a weighted performance indicator; and summing each of the weighted performance indicators for each production well to provide a unit-less performance index value for each production well.

Abstract: A system, computer-readable storage medium storing at least one program, and a computer-implemented method for generating game configurations are presented. For example, a system may receive a game configuration request message from a client device being operated by a player playing a virtual game. The game configuration request message may be sent, for example, in response to the player initiating a new game of the virtual game. The system may then select a game configuration based at least in part on historical performance data associated with the selected game configuration. The historical performance data may accumulate performance data from a group of players that previously played the virtual game using the selected game configuration. The system then communicates the selected game configuration to the client device. The player may play the virtual game using the selected game configuration as the initial game configuration for the virtual game.

Abstract: The present disclosure relates to nucleic acids that encode polypeptides with cytochrome P450 activity involved in the biosynthesis of plant derived diterpenoids or diterpenes.

Abstract: A method of performing aspects of an energy industry operation includes simulating an energy industry operation parameter by an analysis module, wherein simulating includes predicting values of the operational parameter via one or more mathematical models of the assembly and a formation region, and estimating an uncertainty range of at least one of the input data and the predicted values of the operational parameter; generating a performance envelope based on the predicted values and the uncertainty range; generating an operating envelope by the analysis module, the operating envelope prescribing minimum constraints on the operational parameter; during the energy industry operation, receiving real time measurements of the operational parameter by a production performance module, and comparing the measured operational parameter to the operating envelope and the performance envelope; and based on the measured operational parameter being outside the performance envelope, controlling the energy industry operation

Abstract: A machine having one or more cylinders, each cylinder having an inner surface configured to engage a circumferential surface of a piston ring of a piston thereby defining a contact zone between the inner surface of the cylinder and the circumferential surface of the piston ring, the inner surface having at least one recess indented into the inner surface, wherein the ratio of the dimension of the recess in the direction of travel of the piston to the dimension of the contact zone in the direction of travel of the piston is in the range of approximately 1:5 to 3:5.

Abstract: Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like Duchene Muscular Dystrophy so that the disease is more like Becker Muscular Dystrophy. This is a severe reduction in symptom severity and mortality.

Abstract: The present disclosure relates to nucleic acids that encode enzyme activities involved in the synthesis of lathyranes, intermediates in the synthesis of lathyranes and also compounds derived from lathyranes such as tiglianes, daphnanes and ingenanes; cells transformed with the nucleic acid molecules and vectors comprising the nucleic acid molecules.

Abstract: The present disclosure relates to nucleic acids that encode polypeptides with cytochrome P450 activity involved in the biosynthesis of plant derived diterpenoids or diterpenes.

Abstract: A piston ring for a piston, the piston ring having a circumferential surface configured to engage an inner surface of a cylinder, the inner surface having at least one recess indented into the inner surface, the engagement of the circumferential surface of the piston ring with the inner surface of the cylinder defining a contact zone therebetween, wherein the circumferential surface of the piston ring is configured such that the ratio of the dimension of the contact zone the direction of travel of the piston to the dimension of the recess in the direction of travel of the piston is in the range of approximately 5:1 to 5:3.