Abstract: There is disclosed a reactor apparatus including a support element that is rotatable about an axis and which has a first surface generally centered on the axis. The first surface is adapted for outward radial flow of a thin film of fluid phase reactant thereacross when supplied thereto as the support element is rotated. The support element also has a second surface opposed to the first surface and which is in thermal communication with the first surface. The second surface is provided with a spiral passageway generally centered on the axis and also with means for supplying a heat transfer fluid to the spiral passageway. By providing a spiral passageway for the heat transfer fluid, improved heat transfer from the first surface to the heat transfer fluid is obtained.

Abstract: The present invention discloses pteridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.

Abstract: Agents are provided which are capable of inhibiting the cell division cycle in a target cell of interest. The agents comprise first and second components, wherein the first component is a targeting moiety which is capable of directing the second component to the target cell of interest. The second component is capable of inhibiting the cell division cycle in the target cell of interest. The agents are preferably provided in the form of conjugates, and the second component is preferably a cytolethal distending toxin. Methods for the preparation of the agents, and the use thereof for treating proliferative cell disorders and intracellular pathogens are also provided.

Abstract: Agents are provided which are capable of inhibiting the cell division cycle in a target cell of interest. The agents comprise first and second components, wherein the first component is a targeting moiety which is capable of directing the second component to the target cell of interest. The second component is capable of inhibiting the cell division cycle in the target cell of interest. The agents are preferably provided in the form of conjugates, and the second component is preferably a cytolethal distending toxin. Methods for the preparation of the agents, and the use thereof for treating proliferative cell disorders and intracellular pathogens are also provided.

Abstract: The invention relates to 2-aminoimidazopyridine derivatives useful in treating disorders that are mediated by A2a receptor function, including neurodegenerative diseases including Parkinson's disease and inflammation.

Abstract: A reactor apparatus including a support element rotatable about an axis (1) and having a surface (2) generally centred on the axis. The surface (2) is adapted for outward flow of a thin film of a liquid phase reactant thereacross when supplied thereto as the surface (2) is rotated. The reactor apparatus is further provided with a plate or shroud (10) that covers or is coextensive with the surface (2) and defines a gap (14) between the surface and an underside of the plate or shroud (10) so as to allow a gaseous phase flow through the gap (14) and over the thin film of the liquid phase reactant. By constraining the gaseous phase flow over the liquid phase component, especially when the gaseous phase flow is countercurrent to the liquid phase flow, excellent mass transfer between the two phases can be achieved.

Abstract: Compounds of the formula are disclosed as Mnk2 inhibitors which are useful for the treatment and prevention of metabolic disorders such as obesity and diabetes.

Abstract: N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-? expression utilizing compounds of the present invention are also disclosed.

Abstract: There is disclosed a spinning disc reactor having a reaction surface and a hollow main body within which is disposed a spreader plate for defining a flow path for heat transfer fluid. The spreader plate is profiled so that the distance between an internal surface of the main body of the spinning disc reactor and the spreader plate is not constant along a radius of the spinning disc reactor, thereby allowing the radial velocity of the heat transfer fluid to be controlled, for example so as to be constant. This arrangement gives rise to improved heat transfer performance.

Abstract: The invention relates to aminopurine derivatives useful in treating disorders that are mediated by adenosine receptor function, including neurodegenerative diseases and inflammation.

Abstract: N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-? expression utilizing compounds of the present invention are also disclosed.

Abstract: A pathology distribution system 10 is provided for automated sample container 14, 15 distribution. The system 10 comprises a loading station 500 for loading samples in primary containers 14 of different types, a sample handling station 16 for receiving the containers 14 and identifying the container types and samples therein, and a container distribution station 38 for distributing the containers in areas or racks in the distribution station 38 marked for analyzing processes prescribed for the samples therein.

Abstract: N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-? expression utilizing compounds of the present invention are also disclosed.

Abstract: A reactor including a rotatable disc (3) having first (5, 19) and second (20, 30) surfaces. Reactant (15) is supplied to the first surface (5, 19) by way of a feed (4), the disc (3) is rotated at high speed, and the reactant (15) forms a film (17) on the surface (5, 19). As the reactant (15) traverses the surface (5, 19) of the disc (3), it undergoes chemical or physical processes before being thrown from the periphery of the disc (3) into collector means (7). Means for supplying a heat transfer fluid (35) to the second surface (20, 30) are also provided so as to allow the first surface (5, 19) and hence the reactant (15) to be cooled or heated.

Abstract: A method of conducting polymerisation reactions on a rotating surface reactor which allows substantially increased conversions (up to around 99%) to be achieved without a corresponding increase in polydispersity as would be expected as a result of the Trommsdorff-Norrish effect. The rotating surface reactor serves to disentangle and/or stretch growing polymer chains so as to result in better control over polymerisation kinetics.

Abstract: A method of conducting polymerisation reactions on a rotating surface reactor which allows substantially increased conversions (up to around 99%) to be achieved without a corresponding increase in polydispersity as would be expected as a result of the Trommsdorff-Norrish effect. The rotating surface reactor serves to disentangle and/or stretch growing polymer chains so as to result in better control over polymerisation kinetics.

Abstract: A reactor including a rotatable disc (3) having a region (13) in an upper surface (5) thereof. Reactant (15) is supplied to the region (13) by way of a feed (4), the disc (3) is rotated at high speed, and the reactant (15) moves from the region (13) so as to form a film (17) on the surface (5). As the reactant (15) traverses the surface (5) of the disc (3), it undergoes chemical or physical processes before being thrown from the periphery of the disc (3) into collector means (7).

Abstract: A reactor including a rotatable disc (3) having a surface (5) onto which reactant (15) is supplied by way of a feed (4). The disc (3) is rotated at high speed, and the reactant (15) spills over the surface (5) so as to form a film (17). A shear member (18, 20) is mounted close to the surface (5) so as to contact the film (17) during operation of the reactor, thereby applying a shearing force to the reactant (15) so as to aid mixing.

Abstract: N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-? expression utilizing compounds of the present invention are also disclosed.

Abstract: A reactor including a rotatable disc (3) having a trough (13) in an upper surface (5) thereof. Reactant (15) is supplied to the trough (13) by way of a feed (4), the disc (3) is rotated at high speed, and the reactant (15) spills out of the trough (13) so as to form a film (17) on the surface (5). As the reactant (15) traverses the surface (5) of the disc (3), it undergoes chemical or physical processes before being thrown from the periphery of the disc (3) into collector means (7).