Abstract: A portable temperature-controlled container for receiving and housing one or more handheld carriers, each handheld carrier configured to transfer samples to and from a temperature-controlled storage environment, the handheld carrier including a handle and a tray portion, the tray portion configured to be slid into a port of a rack or tower provided in the temperature-controlled storage environment in order to withdraw a sample located in the port, the portable temperature-controlled container including a housing having an opening forming an internal cavity configured to receive one or more handheld carriers, and a lid configured to substantially close the opening, where the housing includes a recess configured to receive the handle of the handheld carrier such that closing of the lid substantially seals the internal cavity when the one or more handheld carriers are placed in the housing.

Abstract: A portable temperature-controlled container for receiving and housing one or more handheld carriers, each handheld carrier configured to transfer samples to and from a temperature-controlled storage environment, the handheld carrier including a handle and a tray portion, the tray portion configured to be slid into a port of a rack or tower provided in the temperature-controlled storage environment in order to withdraw a sample located in the port, the portable temperature-controlled container including a housing having an opening forming an internal cavity configured to receive one or more handheld carriers, and a lid configured to substantially close the opening, where the housing includes a recess configured to receive the handle of the handheld carrier such that closing of the lid substantially seals the internal cavity when the one or more handheld carriers are placed in the housing.

Abstract: A system is provided for transporting, handling and monitoring samples in a temperature-controlled storage environment. The system includes a handheld carrier configured to transfer samples to and from a temperature-controlled storage station and a temperature-controlled container for receiving and housing one or more carriers. The carrier includes an integrated sample identification and temperature sensing capability configured to monitor a thermal history of one or more samples during transport, handling and storage including as the samples are conveyed between the temperature-controlled storage environment and the temperature-controlled container. That is, the carrier is adapted to be held in the hand during use. A carrier for conveying and monitoring samples during transport, handling and storage is also provided.

Abstract: A device for indicating violation of a temperature limit of an item is provided. The device is positionable near the item and includes a sensor configured to change its state permanently when the temperature limit is violated. The change in sensor state is machine-readable to provide a permanent indication of the temperature limit violation. The sensor includes a reservoir for storing a fluid that changes phase from a solid to a liquid when the temperature limit is violated and a channel in fluid communication with the reservoir for receiving flow of the fluid in liquid phase from the reservoir. The sensor is arranged to allow flow of the fluid in the liquid phase such that the state of the sensor is permanently changed. The sensor is further configured to prevent the fluid flow from permanently changing the sensor state until activation of the sensor from a resting state. A system and method for detecting violation of a temperature limit of an item using the device is also provided.

Abstract: Techniques for monitoring dispensed liquid include an intelligent spout that incorporates an IMU (Inertial Measurement Unit) for tracking its own orientation and movement in three-dimensional space. The spout has its own processor, memory, and wireless networking components, which support local data processing, data logging, and bi-directional wireless communication. Communication may be carried out with a server, with other spouts of like kind, and/or with other devices.

Abstract: The present invention provides a CAR comprising a) an antigen binding domain specific for an antigen, b) a spacer, c) a transmembrane domain, and d) an intracellular signaling domain, wherein said spacer consists of 1, 2 or 3 C2-set Ig-like domain(s). Said C2-set Ig-like domain(s) may be selected from the group of C2-set Ig-like domains of the sialic acid binding Ig-like lectin (Siglec) family. A composition comprising a) an immune cell expressing said CAR, wherein said CAR is specific for a tag and b) a tagged polypeptide is also disclosed.

Abstract: Techniques for monitoring dispensed liquid include an intelligent spout that incorporates an IMU (Inertial Measurement Unit) for tracking its own orientation and movement in three-dimensional space. The spout has its own processor, memory, and wireless networking components, which support local data processing, data logging, and bi-directional wireless communication. Communication may be carried out with a server, with other spouts of like kind, and/or with other devices.

Abstract: A system and method of selecting a frame capturing a short duration action from a video. The method including receiving a sequence of frames of the video; and determining a reference frame in the sequence of frames by detecting a predetermined action captured in one of a first plurality of frames from the sequence of video frames, the first plurality of frames being sampled from the sequence of frames at a first sampling rate lower than that of the sequence of frames. The method further comprises selecting a second plurality of frames from the sequence of frames, the second plurality of frames having a location associated with the reference frame in the sequence and being selected at a second sampling rate, the second sampling rate being higher than the first sampling rate; and selecting the frame capturing the short duration action from the second plurality of frames.

Abstract: A wearable device is provided for wirelessly reading data in a temperature-controlled environment, the wearable device being adapted to be worn on an upper limb of a user, wherein the wearable device includes an antenna and circuitry adapted to activate the antenna and wirelessly read data from a machine-readable tag in the temperature-controlled environment.

Abstract: Techniques are disclosed for detection-based wakeup of detection devices. A method may include generating a mapping that includes entries. Each entry may associate a respective detection result of a first detection device with a respective detection result of a second detection device. The method may further include transitioning the second detection device to a first power mode upon completing the generating. The method may further include determining, by the first detection device, that a first object of a first object type is detected based on the mapping. The method may further include transitioning the second detection device out of the first power mode when the first object of the first object type is determined to be detected. The method may further include performing, by the second detection device, at least one action based on the first object. Related systems and devices are also disclosed.

Abstract: A method of detecting a change in angular position of a camera. A plurality of frames captured by the camera is received, each frame being associated with brightness and acceleration metadata. The brightness metadata is associated with a frame being representative of brightness of a scene captured by the frame. A contiguous set of candidate panning motion frames is selected from the plurality of frames, based on similarity of acceleration characteristics, to determine a change of brightness metadata in the selected contiguous set of frames. An angular movement score is determined for the selected contiguous set of frames using the change of brightness metadata. A change in the angular position of the camera is detected based on the angular movement score to adjust a manner in which the plurality of frames is displayed by a display device coupled with the camera.

Abstract: A system and method of selecting a frame capturing a short duration action from a video. The method including receiving a sequence of frames of the video; and determining a reference frame in the sequence of frames by detecting a predetermined action captured in one of a first plurality of frames from the sequence of video frames, the first plurality of frames being sampled from the sequence of frames at a first sampling rate lower than that of the sequence of frames. The method further comprises selecting a second plurality of frames from the sequence of frames, the second plurality of frames having a location associated with the reference frame in the sequence and being selected at a second sampling rate, the second sampling rate being higher than the first sampling rate; and selecting the frame capturing the short duration action from the second plurality of frames.

Abstract: A device for indicating violation of a temperature limit of an item is provided. The device is positionable near the item and includes a sensor configured to change its state permanently when the temperature limit is violated. The change in sensor state is machine-readable to provide a permanent indication of the temperature limit violation. The sensor includes a reservoir for storing a fluid that changes phase from a solid to a liquid when the temperature limit is violated and a channel in fluid communication with the reservoir for receiving flow of the fluid in liquid phase from the reservoir. The sensor is arranged to allow flow of the fluid in the liquid phase such that the state of the sensor is permanently changed. The sensor is further configured to prevent the fluid flow from permanently changing the sensor state until activation of the sensor from a resting state. A system and method for detecting violation of a temperature limit of an item using the device is also provided.

Abstract: The present invention provides a process for generation of genetically modified T cells, T cell subsets and/or T cell progenitors comprising the steps: a) providing a cell sample comprising T cells, T cell subsets and/or T cell progenitors b) preparation of the cell sample by centrifugation c) magnetic separation of the T cells, T cell subsets and/or T cell progenitors d) activation of the enriched T cells, T cell subsets and/or T cell progenitors using modulatory agents e) genetic modification of the T cells, T cell subsets and/or T cell progenitors f) expansion of the genetically modified T cells, T cell subsets and/or T cell progenitors in a cultivation chamber g) washing of the cultured T cells, T cell subsets and/or T cell progenitors characterized in that all steps are performed in a closed and sterile cell culture system.

Abstract: A method of detecting a change in angular position of a camera. A plurality of frames captured by the camera is received, each frame being associated with brightness and acceleration metadata. The brightness metadata is associated with a frame being representative of brightness of a scene captured by the frame. A contiguous set of candidate panning motion frames is selected from the plurality of frames, based on similarity of acceleration characteristics, to determine a change of brightness metadata in the selected contiguous set of frames. An angular movement score is determined for the selected contiguous set of frames using the change of brightness metadata. A change in the angular position of the camera is detected based on the angular movement score to adjust a manner in which the plurality of frames is displayed by a display device coupled with the camera.

Abstract: Techniques are disclosed for detection-based wakeup of detection devices. A method may include generating a mapping that includes entries. Each entry may associate a respective detection result of a first detection device with a respective detection result of a second detection device. The method may further include transitioning the second detection device to a first power mode upon completing the generating. The method may further include determining, by the first detection device, that a first object of a first object type is detected based on the mapping. The method may further include transitioning the second detection device out of the first power mode when the first object of the first object type is determined to be detected. The method may further include performing, by the second detection device, at least one action based on the first object. Related systems and devices are also disclosed.

Abstract: A system and method for the detection of bacteria on a sample, utilizes spectroscopic analysis of the sample and the fluorescent properties of bacteria or other substance(s) or matter associated with the bacteria to identify the presence of bacteria on the sample. A detector analyses light emitted from the sample in response to illumination. The detector 5 is arranged to analyze the emission spectra across two wavebands, a first waveband containing the wavelengths associated with the fluorescent properties of the bacterial species or other substance or matter to be detected, and a second waveband excluding these wavelengths but also having an overlapping region with the first waveband.

Abstract: A method of compositing layers by grouping the layers into a foreground group and a background group; identifying independent instructions of compositing model for execution independently from the background group and dependent instructions requiring a compositing output of a background layer in order to composite foreground layers; executing the independent instructions on the foreground layers in parallel with compositing the background layers, a first independent instruction storing a corresponding result in a first buffer and a second independent instruction storing a corresponding result in a second buffer; executing a dependent instruction by updating the second buffer using the background compositing output; and determining a compositing output for the foreground group dependent upon contents of the first buffer and the updated second buffer.

Abstract: The present invention provides a process for generation of genetically modified T cells, T cell subsets and/or T cell progenitors comprising the steps: a) providing a cell sample comprising T cells, T cell subsets and/or T cell progenitors b) preparation of the cell sample by centrifugation c) magnetic separation of the T cells, T cell subsets and/or T cell progenitors d) activation of the enriched T cells, T cell subsets and/or T cell progenitors using modulatory agents e) genetic modification of the T cells, T cell subsets and/or T cell progenitors f) expansion of the genetically modified T cells, T cell subsets and/or T cell progenitors in a cultivation chamber g) washing of the cultured T cells, T cell subsets and/or T cell progenitors characterized in that all steps are performed in a closed and sterile cell culture system.

Abstract: The invention relates to a process for generation of genetically modified stem cells comprising the steps a) providing a cell sample in suspension comprising stem cells in a centrifugation chamber comprising a base plate and cover plate connected by a cylinder b) adjusting the volumetric concentration of stem cells in the cell sample to at least 1×105 stem cells per mL cell sample by centrifugation c) introducing viral and/or non-viral vectors to the centrifugation chamber for genetically modifying the stem cells d) adjusting the spatial concentration of stem cells in the centrifugation chamber by rotating the centrifugation chamber at a speed where the cell sample is located at the outermost 35% of the radius of the base plate of the centrifugation chamber, thereby inducing gene modification of the stem cells.