Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: The water treatment cartridge is a cartridge adapted to fit into a conventional water filter housing to release a sanitizing dose of a water-treating chemical, and in particular chlorine dioxide, into a water treatment system or unit process. The cartridge is filled with a water treating media, comprised preferably of a mixture of an inert filler material and a chemical composition that releases chlorine dioxide on contact with water. The concentration of the chlorine dioxide released into the water, as well as the duration of the release, may be varied by the selection of the filler material and amount of the filler material in the water treating media.