Abstract: A computer-implemented method and a system for managing signals generated by onboard systems of a mobile equipment fleet, where each of the signals contain operating condition information associated with one of the items of the fleet. The system continuously receives the signals as transmitted by the onboard systems via a communications network. For each of the received signals, the system selects a rule from a rules database based on the equipment operating condition information in the received signal. The rule contains a cause and an action associated with an equipment operating condition. The system generates a report that includes the equipment operating condition, the cause and the action of the selected rule and transmits it to an operator device via the communications network.

Abstract: A method of accessing program meta-data is disclosed. The method includes receiving a plurality of program meta-data virtual containers, at least one of the virtual containers comprising normalized program meta-data of programs having instances in a plurality of time windows, receiving an input indicating a selected time window, the input at least one of comprises and refers to a time-window identifier identifying the selected time window, and using the time-window identifier to filter the plurality of virtual containers, so as to obtain a subset of the program meta-data which corresponds to the selected time window. Related apparatus and methods are also disclosed.

Abstract: A method of accessing program meta-data is disclosed. The method includes receiving a plurality of program meta-data virtual containers, at least one of the virtual containers comprising normalized program meta-data of programs having instances in a plurality of time windows, receiving an input indicating a selected time window, the input at least one of comprises and refers to a time-window identifier identifying the selected time window, and using the time-window identifier to filter the plurality of virtual containers, so as to obtain a subset of the program meta-data which corresponds to the selected time window. Related apparatus and methods are also disclosed.

Abstract: A method of accessing program meta-data is disclosed. The method includes receiving a plurality of program meta-data virtual containers, at least one of the virtual containers comprising normalized program meta-data of programs having instances in a plurality of time windows, receiving an input indicating a selected time window, the input at least one of comprises and refers to a time-window identifier identifying the selected time window, and using the time-window identifier to filter the plurality of virtual containers, so as to obtain a subset of the program meta-data which corresponds to the selected time window. Related apparatus and methods are also disclosed.

Abstract: A method of accessing program meta-data is disclosed. The method includes receiving a plurality of program meta-data virtual containers, at least one of the virtual containers comprising normalized program meta-data of programs having instances in a plurality of time windows, receiving an input indicating a selected time window, the input at least one of comprises and refers to a time-window identifier identifying the selected time window, and using the time-window identifier to filter the plurality of virtual containers, so as to obtain a subset of the program meta-data which corresponds to the selected time window. Related apparatus and methods are also disclosed.

Abstract: A method of accessing program meta-data is disclosed. The method includes receiving a plurality of program meta-data virtual containers, at least one of the virtual containers comprising normalized program meta-data of programs having instances in a plurality of time windows, receiving an input indicating a selected time window, the input at least one of comprises and refers to a time-window identifier identifying the selected time window, and using the time-window identifier to filter the plurality of virtual containers, so as to obtain a subset of the program meta-data which corresponds to the selected time window. Related apparatus and methods are also disclosed.

Abstract: A method of accessing program meta-data is disclosed. The method includes receiving a plurality of program meta-data virtual containers, at least one of the virtual containers comprising normalized program meta-data of programs having instances in a plurality of time windows, receiving an input indicating a selected time window, the input at least one of comprises and refers to a time-window identifier identifying the selected time window, and using the time-window identifier to filter the plurality of virtual containers, so as to obtain a subset of the program meta-data which corresponds to the selected time window. Related apparatus and methods are also disclosed.

Abstract: The invention relates to the use of IFN-beta in the manufacture of a medicament for the treatment of an HCV infection in a treatment-naïve patient belonging to the Asian population.

Abstract: The present invention relates to the use of recombinant IFN-beta for the production of a medicament for the treatment of HCV infection by subcutaneous administration to patients of Asian race, which failed to respond to a previous treatment with interferon-alpha, is herein reported. According to a preferred embodiment of the invention, this treatment can be better and further focused to those patients which after at least 4 weeks of initial treatment with IFN-beta show HCV RNA clearance.

Abstract: The present invention relates to the use of recombinant IFN-beta for the production of a medicament for the treatment of HCV infection by subcutaneous administration to patients of Asian race, which failed to respond to a previous treatment with interferon-alpha, is herein reported. According to a preferred embodiment of the invention, this treatment can be better and further focused to those patients which after at least 4 weeks of initial treatment with IFN-beta show HCV RNA clearance.

Abstract: A pharmaceutical knowledge base is provided that contains multiple information items stored in at least one computer. Pharmaceutical knowledge is represented in a multi-dimensional coordinate space having at least first, second and third axes, where the first axis pertains to diseases, the second axis pertains to targets, and the third axis pertains to drug compounds. Pharmaceutical knowledge may be mapped into the multi-dimensional coordinate space by assigning each information item one or more locations in the space, dependent upon the data contained within the information item. This mapping may then be used to reveal hitherto unappreciated connections between the axes, such as the potential use of a particular compound or target for treating a certain disease.

Abstract: A produce sizing transport mechanism includes an endless conveyor carrying a plurality of downwardly depending produce retaining members which define an elongated produce retaining zone below at least one portion of the endless conveyor. At least part of the produce retaining members may be movable between a first closed position in which produce is retained within the elongated produce retaining zone and a plurality of further open positions enabling produce of predetermined sizes or size ranges to be released from the produce retaining zone. The retaining members may include a produce support region located generally beneath the produce retaining zone when the produce retaining members are located in the first closed position.

Abstract: The present invention provides novel antiviral naphthoquinone compounds, which may be isolated from plants of the genus Conospermum or synthesized chemically, in accordance with the present inventive methods. The antiviral naphthoquionone compounds, derivatives thereof, and prodrugs thereof, may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.

Abstract: The present invention provides novel antiviral naphthoquinone compounds, which may be isolated from plants of the genus Conospermum or synthesized chemically, in accordance with the present inventive methods. The antiviral naphthoquionone compounds, derivatives thereof, and prodrugs thereof, may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.

Abstract: The present invention provides novel antiviral naphthoquinone compounds, which may be isolated from plants of the genus Conospermum or synthesized chemically, in accordance with the present inventive methods. The antiviral naphthoquionone compounds, derivatives thereof, and prodrugs thereof, may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.

Abstract: A semi-automatic bag filling and weighing machine is disclosed including a rotatable indexing table supporting a bag at four spaced locations around the table, a conveyor device for supplying articles to be weighed and filled into the bags, a weighing and filling station to which the bags are moved by the indexing table, a weighing and sensing device for actuating power cylinders operating in conjunction with the filling station, the indexing table and other control devices to move the indexing table so as to replace a filled bag with an empty bag at the filling station. Quick release bag clamping devices are also provided.