Patents by Inventor Ian Wheeldon

Ian Wheeldon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LEUCINE BETA ROLL DOMAINS AND USES THEREOF
    Publication number: 20190017041
    Abstract: In one aspect, the invention relates to a peptide that forms a calcium-dependent hydrogel using a rationally engineered beta roll peptide. In the absence of calcium, the peptide is intrinsically disordered. Upon addition of calcium, the peptide forms a corkscrew-like structure. In one embodiment, one face of the beta roll is mutated to comprise leucine residues. In some embodiments, a leucine zipper forming helical domain to the engineered beta roll forms hydrogels by physical cross-linking in calcium rich environments.
    Type: Application
    Filed: July 23, 2018
    Publication date: January 17, 2019
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Scott BANTA, Mark A. BLENNER, Ian WHEELDON, Kevin DOOLEY
  • Leucine beta roll domains and uses thereof
    Patent number: 10059934
    Abstract: In one aspect, the invention relates to a peptide that forms a calcium-dependent hydrogel using a rationally engineered beta roll peptide. In the absence of calcium, the peptide is intrinsically disordered. Upon addition of calcium, the peptide forms a corkscrew-like structure. In one embodiment, one face of the beta roll is mutated to comprise leucine residues. In some embodiments, a leucine zipper forming helical domain to the engineered beta roll forms hydrogels by physical cross-linking in calcium rich environments.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: August 28, 2018
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Scott Banta, Mark A. Blenner, Ian Wheeldon, Kevin Dooley
  • LEUCINE BETA ROLL DOMAINS AND USES THEREOF
    Publication number: 20160152966
    Abstract: In one aspect, the invention relates to a peptide that forms a calcium-dependent hydrogel using a rationally engineered beta roll peptide. In the absence of calcium, the peptide is intrinsically disordered. Upon addition of calcium, the peptide forms a corkscrew-like structure. In one embodiment, one face of the beta roll is mutated to comprise leucine residues. In some embodiments, a leucine zipper forming helical domain to the engineered beta roll forms hydrogels by physical cross-linking in calcium rich environments.
    Type: Application
    Filed: July 30, 2015
    Publication date: June 2, 2016
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Scott BANTA, Mark A. BLENNER, Ian WHEELDON, Kevin DOOLEY
  • Leucine beta roll domains and uses thereof
    Patent number: 9127267
    Abstract: In one aspect, the invention relates to a peptide that forms a calcium-dependent hydrogel using a rationally engineered beta roll peptide. In the absence of calcium, the peptide is intrinsically disordered. Upon addition of calcium, the peptide forms a corkscrew-like structure. In one embodiment, one face of the beta roll is mutated to comprise leucine residues. In some embodiments, a leucine zipper forming helical domain to the engineered beta roll forms hydrogels by physical cross-linking in calcium rich environments.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: September 8, 2015
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Scott Banta, Mark A. Blenner, Ian Wheeldon, Kevin Dooley