Abstract: To provide fine particle films including fine particles which are arranged at a high density in a highly accurate and regular manner is enabled. The fine particle film is a fine particle film including a substrate and plural number of protein fine particles which are arranged on the surface of the substrate in a plane direction parallel to the surface of the substrate, wherein each of the protein fine particles has plural number of first binding sites and one or more second binding sites respectively including a condensed amino acid, and each of the first binding sites binds to other first binding site carried by an adjacent fine particle while the second binding site binds to the substrate, wherein at least a part of the condensed amino acids constituting the second binding site are substituted.

Abstract: Using a gene recombination technique, a glutamic acid and an aspartic acid positioned in a channel of apoferritin are substituted with serine having a small size and no charges. Then, a glutamic acid positioned in a holding portion is substituted with a basic amino acid such as lysine or a neutral amino acid. Furthermore, at least one cysteine is introduced into the holding portion. This prevents a repulsive force due to electrostatic interaction between (AuCl4)? having a negative charge and a negative amino acid from occurring, which facilitates the capture of (AuCl4)? into the channel and the holding portion. The (AuCl4)? captured into the holding portion is subsequently reduced to Au, and thus apoferritin including gold particles can be produced.

Abstract: An object of the present invention is to provide a method of forming fine particles on a substrate in which reoxidization of reduced fine particles is suppressed. Reduced fine particles (FeO fine particles) are formed by embedding metal oxide fine particles (Fe2O3 fine particles) fixed on a p type silicon semiconductor substrate into a silicon oxidized film, and carrying out a heat treatment in a reducing gas atmosphere. Presence of the silicon oxidized film enables suppression of reoxidization of the reduced fine particles (FeO fine particles) due to exposure to the ambient air.

Abstract: A quantum device is constituted from a two-dimensional array of quantum dots formed from metal atom aggregates contained in a metalloprotein complex. The metalloprotein is arranged on the surface of a substrate having an insulation layer with a pitch of the size of the metalloprotein complex. The diameter of the metal atom aggregates used in the quantum device is 7 nm or smaller, and the pitch of the metalloprotein complex is preferably from 11 to 14 nm.

Abstract: Using a gene recombination technique, a glutamic acid and an aspartic acid positioned in a channel of apoferritin are substituted with serine having a small size and no charges. Then, a glutamic acid positioned in a holding portion is substituted with a basic amino acid such as lysine or a neutral amino acid. Furthermore, at least one cysteine is introduced into the holding portion. This prevents a repulsive force due to electrostatic interaction between (AuCl4)? having a negative charge and a negative amino acid from occurring, which facilitates the capture of (AuCl4)? into the channel and the holding portion. The (AuCl4)? captured into the holding portion is subsequently reduced to Au, and thus apoferritin including gold particles can be produced.

Abstract: A radiotherapy apparatus comprising an irradiation head having a linear accelerator and an intra-head waveguide unit whose one end portion is electromagnetically connected to the linear accelerator, a supporting moving mechanism which supports and moves the irradiation head on predetermined first spherical coordinates, a microwave oscillator which generates microwaves to be supplied to the irradiation head, and which is placed in a stationary position, a fixed waveguide unit having one end portion electromagnetically connected to the microwave oscillator, and the other end portion positioned on the supporting moving mechanism, and a moving waveguide unit having one end portion electromagnetically connected to the other end portion of the fixed waveguide unit positioned on the supporting moving mechanism.

Abstract: A novel structure comprising two substrates disposed closely each other, in which an organic molecular layer is formed on the surface of at least one substrate wherein the gap between the surface of the organic molecular layer on one substrate and the surface of the other substrate or the surface of the organic molecular layer on the other substrate is maintained to be usually less than 100 ?m, preferably less than 1 ?m is provided. A motor, actuator, and vibration-absorbing table comprising such structure are also provided.

Abstract: A method of the production of a nanoparticle dispersed composite material capable of controlling a particle size and a three dimensional arrangement of the nanoparticles is provided. The method of the production of a nanoparticle dispersed composite material of the present invention includes a step (a) of arranging a plurality of core fine particle-protein complexes having a core fine particle, which comprises an inorganic material, internally included within a protein on the top surface of a substrate, a step (b) of removing the protein, a step (c) of conducting ion implantation from the top surface of the substrate, and a step (d) of forming nanoparticles including the ion implanted by the ion implantation as a raw material, inside of the substrate.

Abstract: A two-dimensional crystalline film of ferritin 4 holding iron-oxide cores 1 is formed on a silicon substrate 6. The silicon substrate 6 is then etched by using at least the cores 1 as an etching mask. Since the cores 1 have a small diameter of 6 nm, a fine structure can be formed on the substrate, enabling manufacturing of a semiconductor light-emitting element and various semiconductor devices using a quantum effect.

Abstract: The method of the production of a nanoparticle of the present invention includes a step of forming a nanoparticle including a compound of ametal ion in a cavity part of aprotein, in a solution containing the protein having the cavity part therein, the metal ion, and a carbonate ion and/or a hydrogen carbonate ion. Examples of the aforementioned compound include e.g., a hydroxide. The aforementioned metal ion is preferably any one of a nickel ion (Ni2+), a chromium ion (Cr2+) or a copper ion (Cu2+). According to the aforementioned method, nanoparticles having a uniform particle diameter can be produced.

Abstract: A radiation treatment apparatus includes a guide and a support member. The guide moves a radiation generating unit along an orbit with a predetermined radius such that an X-ray emitted from the radiation generating unit may cross an isocenter. The support member rotates the guide about a turning axis passing through the isocenter. The radiation generating unit is moved along a spherical plane by the guide and the support member and applies the X-ray toward the isocenter in multiple directions.

Abstract: A radiotherapy apparatus comprising an irradiation head having a linear accelerator and an intra-head waveguide unit whose one end portion is electromagnetically connected to the linear accelerator, a supporting moving mechanism which supports and moves the irradiation head on predetermined first spherical coordinates, a microwave oscillator which generates microwaves to be supplied to the irradiation head, and which is placed in a stationary position, a fixed waveguide unit having one end portion electromagnetically connected to the microwave oscillator, and the other end portion positioned on the supporting moving mechanism, and a moving waveguide unit having one end portion electromagnetically connected to the other end portion of the fixed waveguide unit positioned on the supporting moving mechanism.

Abstract: A method for obtaining a cobalt-apoferritin complex according to the present invention includes: the step a) of preparing a solution including a Co2+ ion, a protein, a pH buffer agent and a Co2+ associating agent; and the step b) of adding an oxidizing agent to the solution and thereby making the protein contain a fine particle including cobalt.

Abstract: To provide fine particle films including fine particles which are arranged at a high density in a highly accurate and regular manner is enabled. The fine particle film is a fine particle film including a substrate and plural number of protein fine particles which are arranged on the surface of the substrate in a plane direction parallel to the surface of the substrate, wherein each of the protein fine particles has plural number of first binding sites and one or more second binding sites respectively including a condensed amino acid, and each of the first binding sites binds to other first binding site carried by an adjacent fine particle while the second binding site binds to the substrate, wherein at least a part of the condensed amino acids constituting the second binding site are substituted.

Abstract: (1) Transgenic medaka fish into which a polynucleotide having the nucleotide sequence from 211 to 1935 position represented by Sequence ID No: 1 is introduced, (2) A method of producing medaka fish having one or more thrombi, comprising the step of raising the transgenic medaka fish described in (1) in the presence of estrogen, (3) Medaka fish having one or more thrombi produced by the method described in (2), and (4) A method of testing an estrogen-like acting substance, comprising the steps of raising the transgenic medaka fish described in (1) in test water, and observing whether or not one or more thrombi are formed in the medaka fish after the raising step.

Abstract: The method of the production of a nanoparticle of the present invention includes a step of forming a nanoparticle of a group II-group VI compound semiconductor in the cavity part of a protein, in a solution containing the protein having a cavity part therein represented by apoferritin, the group II element ion represented by Cd and Zn, and the group VI element ion represented by S and Se. Preferably, the solution further includes an ammonium ion, and the supply of the group VI element ion (X2−) into the solution is conducted by adding H2NCXNH2 to the solution. According to the aforementioned method, semiconductor nanoparticles having a uniform particle size can be produced.

Abstract: A novel structure comprising two substrates disposed closely each other, in which an organic molecular layer is formed on the surface of at least one substrate wherein the gap between the surface of the organic molecular layer on one substrate and the surface of the other substrate or the surface of the organic molecular layer on the other substrate is maintained to be usually less than 100 &mgr;m, preferably less than 1 &mgr;m is provided. A motor, actuator, and vibration-absorbing table comprising such structure are also provided.

Abstract: The radiotherapy apparatus in the present invention includes a bed, a radiation irradiating head, head swing mechanisms, a precise inspection unit and a control unit. The bed carries a subject. The radiation irradiating head irradiates a treatment radiation to a treatment field of the subject. The head swing mechanisms, which are coupled to the radiation irradiating head, swings the head of the radiation irradiating head so that the treatment radiation emitted from the radiation irradiating head pursues the motion of the treatment field. The precise inspection unit obtains a diagnosis image containing the treatment field. The control unit controls the positions of the head swing mechanisms so that an irradiation field of the radiation irradiating head pursues the treatment field, based on the diagnosis image, the position of the radiation irradiating head and the state of the swung head.

Abstract: A nucleotide detector 10 includes: metal particles 12 having a size of the order of nanometers (diameter: about 6 nm) placed on a surface of a substrate 11 at high density with high precision (with spaces of about 12 nm between adjacent particles); and single-stranded DNAs (thiol DNAS) 13 having sulfur atoms at ends bonded to the gold particles 12. The thiol DNAS 13 are placed uniformly over the entire substrate 11 at high density with high precision. Therefore, once a fluorescence-labeled single-stranded DNA is hybridized with any of the thiol DNAs 13, high fluorescence intensity is stably obtained. This detector is therefore usable as a high-performance DNA sensor with a high SN ratio.

Abstract: A quantum device is constituted from a two-dimensional array of quantum dots formed from metal atom aggregates contained in a metalloprotein complex. The metalloprotein is arranged on the surface of a substrate having an insulation layer with a pitch of the size of the metalloprotein complex. The diameter of the metal atom aggregates used in the quantum device is 7 nm or smaller, and the pitch of the metalloprotein complex is preferably from 11 to 14 nm.